New light on Galactic post-asymptotic giant branch stars. I. First distance catalogue

We have commenced a detailed analysis of the known sample of Galactic post-asymptotic giant branch (PAGB) objects compiled in the Toru\'n catalogue of Szczerba et al., and present, for the first time, homogeneously derived distance determinations for the 209 likely and 87 possible catalogued PAGB stars from that compilation. Knowing distances are essential in determining meaningful physical characteristics for these sources and this has been difficult to determine for most objects previously. The distances were determined by modelling their spectral energy distributions (SED) with multiple black-body curves, and integrating under the overall fit to determine the total distance-dependent flux. This method works because the luminosity of these central stars is very nearly constant from the tip of the AGB phase to the beginning of the white-dwarf cooling track. This then enables us to use a standard-candle luminosity to estimate the SED distances. For Galactic thin disk PAGB objects, we use three luminosity bins based on typical observational characteristics, ranging between 3500 and 12000 L_sun. We further adopt a default luminosity of 1700 L_sun for all halo PAGB objects. We have also applied the above technique to a further sample of 69 related nebulae not in the current edition of the Toru\'n catalogue. In a follow-up paper we will estimate distances to the subset of RV Tauri variables using empirical period-luminosity relations, and to the R\,CrB stars, allowing a population comparison of these objects with the other subclasses of PAGB stars for the first time.Comment: 24 pages, 8 tables, 4 figures. Submitted to MNRAS. Appendix B containing full list of SED figures excluded in this versio

Concurrent use of prescription drugs and herbal medicinal products in older adults: A systematic review

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The use of herbal medicinal products (HMPs) is common among older adults. However, little is known about concurrent use with prescription drugs as well as the potential interactions associated with such combinations. Objective Identify and evaluate the literature on concurrent prescription and HMPs use among older adults to assess prevalence, patterns, potential interactions and factors associated with this use. Methods Systematic searches in MEDLINE, PsycINFO, EMBASE, CINAHL, AMED, Web of Science and Cochrane from inception to May 2017 for studies reporting concurrent use of prescription medicines with HMPs in adults (≥65 years). Quality was assessed using the Joanna Briggs Institute checklists. The Evidence for Policy and Practice Information and Co-ordinating Centre (EPPI-Centre) three stage approach to mixed method research was used to synthesise data. Results Twenty-two studies were included. A definition of HMPs or what was considered HMP was frequently missing. Prevalence of concurrent use by older adults varied widely between 5.3% and 88.3%. Prescription medicines most combined with HMPs were antihypertensive drugs, beta blockers, diuretics, antihyperlipidemic agents, anticoagulants, analgesics, antihistamines, antidiabetics, antidepressants and statins. The HMPs most frequently used were: ginkgo, garlic, ginseng, St John’s wort, Echinacea, saw palmetto, evening primrose oil and ginger. Potential risks of bleeding due to use of ginkgo, garlic or ginseng with aspirin or warfarin was the most reported herb-drug interaction. Some data suggests being female, a lower household income and less than high school education were associated with concurrent use. Conclusion Prevalence of concurrent prescription drugs and HMPs use among older adults is substantial and potential interactions have been reported. Knowledge of the extent and manner in which older adults combine prescription drugs will aid healthcare professionals can appropriately identify and manage patients at risk.Peer reviewedFinal Published versio

The Trypanosoma cruzi vitamin C dependent peroxidase confers protection against oxidative stress but is not a determinant of virulence.

BACKGROUND: The neglected parasitic infection Chagas disease is rapidly becoming a globalised public health issue due to migration. There are only two anti-parasitic drugs available to treat this disease, benznidazole and nifurtimox. Thus it is important to identify and validate new drug targets in Trypanosoma cruzi, the causative agent. T. cruzi expresses an ER-localised ascorbate-dependent peroxidase (TcAPx). This parasite-specific enzyme has attracted interest from the perspective of targeted chemotherapy. METHODOLOGY/PRINCIPAL FINDINGS: To assess the importance of TcAPx in protecting T. cruzi from oxidative stress and to determine if it is essential for virulence, we generated null mutants by targeted gene disruption. Loss of activity was associated with increased sensitivity to exogenous hydrogen peroxide, but had no effect on susceptibility to the front-line Chagas disease drug benznidazole. This suggests that increased oxidative stress in the ER does not play a significant role in its mechanism of action. Homozygous knockouts could proceed through the entire life-cycle in vitro, although they exhibited a significant decrease in their ability to infect mammalian cells. To investigate virulence, we exploited a highly sensitive bioluminescence imaging system which allows parasites to be monitored in real-time in the chronic stage of murine infections. This showed that depletion of enzyme activity had no effect on T. cruzi replication, dissemination or tissue tropism in vivo. CONCLUSIONS/SIGNIFICANCE: TcAPx is not essential for parasite viability within the mammalian host, does not have a significant role in establishment or maintenance of chronic infections, and should therefore not be considered a priority for drug design

State owned enterprises as bribe payers: the role of institutional environment

Our paper draws attention to a neglected channel of corruption—the bribe payments by state-owned enterprises (SOEs). This is an important phenomenon as bribe payments by SOEs fruitlessly waste national resources, compromising public welfare and national prosperity. Using a large dataset of 30,249 firms from 50 countries, we show that, in general, SOEs are less likely to pay bribes for achieving organizational objectives owing to their political connectivity. However, in deteriorated institutional environments, SOEs may be subjected to potential managerial rent-seeking behaviors, which disproportionately increase SOE bribe propensity relative to privately owned enterprises. Specifically, our findings highlight the importance of fostering democracy and rule of law, reducing prevalence of corruption and shortening power distance in reducing the incidence of SOE bribery

Financial Independence as an Alternative to Work

Paid work, in some form, is traditionally viewed as being a necessity, both to support one’s livelihood and to save for retirement; however, people's increasing disillusionment with employment has led some individuals to search for alternative ways to live. The twenty-one Australians in this exploratory, qualitative study were all seeking, or had achieved, financial independence. This is a lifestyle alternative that provides economic freedom from work, without necessitating a reduction in preferred living standards. To the best of our knowledge, this is the first social research into the lived experiences, beliefs and meanings surrounding financial independence, and offers significant and critical insights into the usual expectations that surround paid work; in particular, routine expectations that continuing paid work until one’s senior years is, and should be, an economic necessity

State-owned enterprises around the world as hybrid organizations

State-owned enterprises represent approximately 10% of global gross domestic product. Yet they remain relatively underexplored by management scholars. Firms have often been viewed dichotomously as either state owned or privately owned. Today, however, we encourage a more nuanced view of state-owned enterprises as hybrid organizations, in which the levels of ownership and control by the state can vary. Drawing on 36 cases from four industries in 23 countries, we lay the groundwork for a richer understanding of state-owned enterprises by management scholars in the future