Sensitivity analysis of oscillating hybrid systems

Thesis (S.M.)--Massachusetts Institute of Technology, Computation for Design and Optimization Program, 2010.Cataloged from PDF version of thesis.Includes bibliographical references (p. 137-140).Many models of physical systems oscillate periodically and exhibit both discrete-state and continuous-state dynamics. These systems are called oscillating hybrid systems and find applications in diverse areas of science and engineering, including robotics, power systems, systems biology, and so on. A useful tool that can provide valuable insights into the influence of parameters on the dynamic behavior of such systems is sensitivity analysis. A theory for sensitivity analysis with respect to the initial conditions and/or parameters of oscillating hybrid systems is developed and discussed. Boundary-value formulations are presented for initial conditions, period, period sensitivity and initial conditions for the sensitivities. A difference equation analysis of general homogeneous equations and parametric sensitivity equations with linear periodic piecewise continuous coefficients is presented. It is noted that the monodromy matrix for these systems is not a fundamental matrix evaluated after one period, but depends on one. A three part decomposition of the sensitivities is presented based on the analysis. These three parts classify the influence of the parameters on the period, amplitude and relative phase of the limit-cycles of hybrid systems, respectively. The theory developed is then applied to the computation of sensitivity information for some examples of oscillating hybrid systems using existing numerical techniques and methods. The relevant information given by the sensitivity trajectory and its parts can be used in algorithms for different applications such as parameter estimation, control system design, stability analysis and dynamic optimization.by Vibhu Prakash Saxena.S.M

Cereal food technologies - India and Africa trends and the need for collaborative and networking programmes

India and Africa share many common food trends such as rapid urbanization and a growing demand for convenience and health-promoting foods.Notably in Africa, these food demands are currently being met by relatively simple value addition to grains through small and medium enterprises.However, achieving improved staple food security will require more complex technologies, higher technical skills and a better organized food pipeline. Thus, in Asia and Africa there is an acute need for collaborative and network programmes in grain science and technology. The recent creation of an ICC India Task Force to make India-International grain science collaboration and networking a reality is a critical step to achieving these goals.http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1757-837

Assessment of different elite mango varieties suitable for North western plain zones of Uttar Pradesh

The evaluation of different mango varieties was conducted during 2019-20 and 2020-21. The experiment was laid out in a randomized block design (RBD) with four varieties, namely, Ambika, Pusa Arunima, Kesar, and Dashehari-51, each replicated three times. The plants were spaced at 4x4 m intervals. The results obtained demonstrated significant variations in various parameters, ranging from minimum to maximum values. The canopy spread ranged from 1.77 to 7.49 m, stem girth from 16.67 to 40 cm, number of fruits per plant from 21 to 118, fruit length from 92.04 to 123.28 mm, fruit width from 56.02 to 77.41 mm, and fruit weight from 202 to 591 g. However, the number of primary branches (2-3) and plant height (1.54-4.35 m) were found to be nonsignificant. Based on the morpho-economic traits, Pusa Arunima appeared to be a superior variety in terms of tree morpho-economic traits, while others were considered moderate. Considering the average number of fruits per plant and fruit weight (g) over a two-year period, Pusa Arunima clearly outperformed the other three varieties in terms of yield. Furthermore, Pusa Arunima, Kesar, and Ambika exhibited more marketable fruit traits. These findings emphasize the significant diversity among the examined mango cultivars. Therefore, it is crucial to protect and preserve these valuable genetic resources for future breeding programs aimed at developing novel and commercially viable cultivars

Henipavirus Infection in Fruit Bats (Pteropus giganteus), India

We tested 41 bats for antibodies against Nipah and Hendra viruses to determine whether henipaviruses circulate in pteropid fruit bats (Pteropus giganteus) in northern India. Twenty bats were seropositive for Nipah virus, which suggests circulation in this species, thereby extending the known distribution of henipaviruses in Asia westward by >1,000 km

OpenFraming: open-sourced tool for computational framing analysis of multilingual data

When journalists cover a news story, they can cover the story from multiple angles or perspectives. These perspectives are called “frames,” and usage of one frame or another may influence public perception and opinion of the issue at hand. We develop a web-based system for analyzing frames in multilingual text documents. We propose and guide users through a five-step end-to-end computational framing analysis framework grounded in media framing theory in communication research. Users can use the framework to analyze multilingual text data, starting from the exploration of frames in user’s corpora and through review of previous framing literature (step 1-3) to frame classification (step 4) and prediction (step 5). The framework combines unsupervised and supervised machine learning and leverages a state-of-the-art (SoTA) multilingual language model, which can significantly enhance frame prediction performance while requiring a considerably small sample of manual annotations. Through the interactive website, anyone can perform the proposed computational framing analysis, making advanced computational analysis available to researchers without a programming background and bridging the digital divide within the communication research discipline in particular and the academic community in general. The system is available online at http://www.openframing.org, via an API http://www.openframing.org:5000/docs/, or through our GitHub page https://github.com/vibss2397/openFraming.Published versio

Effectiveness of Action in India to Reduce Exposure of Gyps Vultures to the Toxic Veterinary Drug Diclofenac

Contamination of their carrion food supply with the non-steroidal anti-inflammatory drug diclofenac has caused rapid population declines across the Indian subcontinent of three species of Gyps vultures endemic to South Asia. The governments of India, Pakistan and Nepal took action in 2006 to prevent the veterinary use of diclofenac on domesticated livestock, the route by which contamination occurs. We analyse data from three surveys of the prevalence and concentration of diclofenac residues in carcasses of domesticated ungulates in India, carried out before and after the implementation of a ban on veterinary use. There was little change in the prevalence and concentration of diclofenac between a survey before the ban and one conducted soon after its implementation, with the percentage of carcasses containing diclofenac in these surveys estimated at 10.8 and 10.7%, respectively. However, both the prevalence and concentration of diclofenac had fallen markedly 7–31 months after the implementation of the ban, with the true prevalence in this third survey estimated at 6.5%. Modelling of the impact of this reduction in diclofenac on the expected rate of decline of the oriental white-backed vulture (Gyps bengalensis) in India indicates that the decline rate has decreased to 40% of the rate before the ban, but is still likely to be rapid (about 18% year−1). Hence, further efforts to remove diclofenac from vulture food are still needed if the future recovery or successful reintroduction of vultures is to be feasible

Removing the Threat of Diclofenac to Critically Endangered Asian Vultures

Veterinary use of the nonsteroidal anti-inflammatory (NSAID) drug diclofenac in South Asia has resulted in the collapse of populations of three vulture species of the genusGyps to the most severe category of global extinction risk. Vultures are exposed to diclofenac when scavenging on livestock treated with the drug shortly before death. Diclofenac causes kidney damage, increased serum uric acid concentrations, visceral gout, and death. Concern about this issue led the Indian Government to announce its intention to ban the veterinary use of diclofenac by September 2005. Implementation of a ban is still in progress late in 2005, and to facilitate this we sought potential alternative NSAIDs by obtaining information from captive bird collections worldwide. We found that the NSAID meloxicam had been administered to 35 captiveGyps vultures with no apparent ill effects. We then undertook a phased programme of safety testing of meloxicam on the African white-backed vultureGyps africanus, which we had previously established to be as susceptible to diclofenac poisoning as the endangered AsianGyps vultures. We estimated the likely maximum level of exposure (MLE) of wild vultures and dosed birds by gavage (oral administration) with increasing quantities of the drug until the likely MLE was exceeded in a sample of 40G. africanus. Subsequently, sixG. africanus were fed tissues from cattle which had been treated with a higher than standard veterinary course of meloxicam prior to death. In the final phase, ten Asian vultures of two of the endangered species(Gyps bengalensis,Gyps indicus) were dosed with meloxicam by gavage; five of them at more than the likely MLE dosage. All meloxicam-treated birds survived all treatments, and none suffered any obvious clinical effects. Serum uric acid concentrations remained within the normal limits throughout, and were significantly lower than those from birds treated with diclofenac in other studies. We conclude that meloxicam is of low toxicity toGyps vultures and that its use in place of diclofenac would reduce vulture mortality substantially in the Indian subcontinent. Meloxicam is already available for veterinary use in India

Robust estimation of bacterial cell count from optical density

Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data

Status of Vultures in Keoladeo National Park, Bharatpur, Rajasthan, with Special Reference To Population Crash in Gyps Species

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