Grains charges in interstellar clouds

The charge of cosmic grains could play an important role in many astrophysical phenomena. It probably has an influence on the coagulation of grains and more generally on grain-grain collisions, and on interaction between charged particles and grains which could lead to the formation of large grains or large molecules. The electrostatic charge of grains depends mainly on the nature of constitutive material of the grain and on the physical properties of its environment: it results from a delicate balance between the plasma particle collection and the photoelectron emission, both of them depending on each other. The charge of the grain is obtained in two steps: (1) using the numerical model the characteristics of the environment of the grain are computed; (2) the charge of a grain which is embedded in this environment is determined. The profile of the equilibrium charge of some typical grains through different types of interstellar clouds is obtained as a function of the depth of the cloud. It is shown that the grain charge can reach high values not only in hot diffuse clouds, but also in clouds with higher densities. The results are very sensitive to the mean UV interstellar radiation field. Three parameters appear to be essential but with different levels of sensitivity of the charge: the gas density, the temperature, and the total thickness of the cloud

Nods, Nalps and Naip: intracellular regulators of bacterial-induced inflammation

The innate immune system is the most ancestral and ubiquitous system of defence against microbial infection. The microbial sensing proteins involved in innate immunity recognize conserved and often structural components of microorganisms. One class of these pattern-recognition molecules, the Toll-like receptors (TLRs), are involved in detection of microbes in the extracellular compartment whereas a newly discovered family of proteins, the NBS-LRR proteins (for nucleotide-binding site and leucine-rich repeat), are involved in intracellular recognition of microbes and their products. NBS-LRR proteins are characterized by three structural domains: a C-terminal leucine-rich repeat (LRR) domain able to sense a microbial motif, an intermediary nucleotide binding site (NBS) essential for the oligomerization of the molecule that is necessary for the signal transduction induced by different N-terminal effector motifs, such as a pyrin domain (PYD), a caspase-activating and recruitment domain (CARD) or a baculovirus inhibitor of apoptosis protein repeat (BIR) domain. Two of these family members, Nod1 and Nod2, play a role in the regulation of pro-inflammatory pathways through NF-κB induced by bacterial ligands. Recently, it was shown that Nod2 recognizes a specific peptidoglycan motif from bacteria, muramyl dipeptide (MDP). A surprising number of human genetic disorders have been linked to NBS-LRR proteins. For example, mutations in Nod2, which render the molecule insensitive to MDP and unable to induce NF-κB activation when stimulated, are associated with susceptibility to a chronic intestinal inflammatory disorder, Crohn's disease. Conversely, mutations in the NBS region of Nod2 induce a constitutive activation of NF-κB and are responsible for Blau syndrome, another auto-inflammatory disease. Nalp3, which is an NBS-LRR protein with an N-terminal Pyrin domain, is also implicated in rare auto-inflammatory disorders. In conclusion, NBS-LRR molecules appear as a new family of intracellular receptors of innate immunity able to detect specific bacterial compounds and induce inflammatory response; the dysregulation of these processes due to mutations in the genes encoding these proteins is involved in numerous auto-inflammatory disorders.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75732/1/j.1462-5822.2003.00304.x.pd

Converting sporting capacity to entrepreneurial capacity: A process perspective

Managing a personal sporting career and conducting an entrepreneurial initiative are two vitally connected processes. Most athletes require a second career and many engage in entrepreneurship. Research on the similarities and differences of the sports career management process and entrepreneurial process with a special emphasis on the necessary capacities will have a ready audience among practitioners. This study begins the task of closing a surprising gap. In entrepreneurship literature, there is (1) growing research on entrepreneurial process and entrepreneurial capacity as the key driver; (2) strong work in generic, descriptive and explanatory modelling of process as a whole and capacity as a sub-process; and (3) the presence of a generic model of entrepreneurial process based of what distinguishes entrepreneurial capacity from other human capacities. In sports management literature, these research strands are virtually absent. The study indicates how the deficiency might be remedied

Self-gravitating clouds of generalized Chaplygin and modified anti-Chaplygin Gases

The Chaplygin gas has been proposed as a possible dark energy, dark matter candidate. As a working fluid in a Friedmann-Robertson-Walker universe, it exhibits early behavior reminiscent of dark matter, but at later times is more akin to a cosmological constant. In any such universe, however, one can expect local perturbations to form. Here we obtain the general equations for a self-gravitating relativistic Chaplygin gas. We solve these equations and obtain the mass-radius relationship for such structures, showing that only in the phantom regime is the mass-radius relationship large enough to be a serious candidate for highly compact massive objects at the galaxy core. In addition, we study the cosmology of a modified anti-Chaplygin gas. A self-gravitating cloud of this matter is an exact solution to Einstein's equations.Comment: 16 page

Dowe really need an accurate calibration pattern?

The metrology of calibration patterns is often a real problem in computer vision to obtain a reliable estimation of the intrinsic and extrinsic parameters that model a video camera device . In order to take into account these errors a self-calibration method is described, that enables us to compute in the same time the traditional calibration parameters and the 3D geometry of the calibration pattern using a multi-images calibration algorithm . Experimental results shows that the proposed algorithm leads to reliable calibration results and proves that calibration errors no longer depend on the accuracy of calibration point measurement, but on the accuracy of calibration point detection in the image plane .Cet article soulève le problème de l'influence des erreurs introduites par la métrologie d'une mire d'étalonnage sur la détermination des paramètres intrinsèques d'un capteur vidéo. Afin de s'affranchir de ces erreurs, une approche d'autocalibrage est décrite permettant conjointement d'estimer les paramètres internes du capteur vidéo et la géométrie de la mire, au sein d'un formalisme d'étalonnage multi-images. Par la problématique qu'il soulève, cet article cotoie les approches de Shape from Motion et d'Auto-calibrage des capteurs, en gardant cependant la spécificité d'être décrit selon un formalisme photogrammétrique et donc d'intégrer implicitement les aberrations géométriques des objectifs. Nous nous sommes attachés à insister sur l'aspect descriptif de la méthode pour permettre aux lecteurs une vision globale de la mise en oeuvre du procédé

CH 3 GHz Observations of the Galactic Center

A 3 $\times$ 3 map of the Galactic Center was made at 9\arcmin resolution and 10\arcmin spacing in the CH $^2\Pi_{1/2}$, J=1/2, F=1-1 transition at 3335 MHz. The CH emission shows a velocity extent that is nearly that of the CO(1-0) line, but the CH line profiles differ markedly from the CO. The 3335 MHz CH transition primarily traces low-density molecular gas and our observations indicate that the mass of this component within $\sim$ 30 pc of the Galactic Center is $\sim$ 9 $\times$ 10$^6$ M$_\odot$. The CO-H$_2$ conversion factor obtained for the low-density gas in the mapped region is greater than that thought to apply to the dense molecular gas at the Galactic Center. In addition to tracing the low-density molecular gas at the Galactic Center, the CH spectra show evidence of emission from molecular clouds along the line of sight both in the foreground and background. The scale height of these clouds ranges from 27 - 109 pc, consistent with previous work based on observations of molecular clouds in the inner Galaxy.Comment: 29 pages, 12 figure

CN and HCN in Dense Interstellar Clouds

We present a theoretical investigation of CN and HCN molecule formation in dense interstellar clouds. We study the gas-phase CN and HCN production efficiencies from the outer photon-dominated regions (PDRs) into the opaque cosmic-ray dominated cores. We calculate the equilibrium densities of CN and HCN, and of the associated species C+, C, and CO, as functions of the far-ultraviolet (FUV) optical depth. We consider isothermal gas at 50 K, with hydrogen particle densities from 10^2 to 10^6 cm^-3. We study clouds that are exposed to FUV fields with intensities 20 to 2*10^5 times the mean interstellar FUV intensity. We assume cosmic-ray H2 ionization rates ranging from 5*10^-17 s^-1, to an enhanced value of 5*10^-16 s^-1. We also examine the sensitivity of the density profiles to the gas-phase sulfur abundance.Comment: Accepted for publication in ApJ, 33 pages, 8 figure

Multi--Pressure Polytropes as Models for the Structure and Stability of Molecular Clouds. I. Theory

Molecular clouds are supported by thermal pressure, magnetic pressure, and turbulent pressure. Each of these can be modeled with a polytropic equation of state, so that overall the total pressure is the sum of the individual components. We model the turbulent pressure as being due to a superposition of Alfven waves. The theory of polytropes is generalized to allow for the flow of entropy in response to a perturbation, as expected for the entropy associated with wave pressure. The equation of state of molecular clouds is "soft", so that the properties of the clouds are generally governed by the conditions at the surface. In general, the polytropes are not isentropic, and this permits large density and pressure drops to occur between the center and the edge of the polytropes, as is observed.Comment: Submitted to ApJ with 10 figure