A [3]Ferrocenophane polyphenol showing a remarkable antiproliferative activity on breast and prostate cancer cell lines

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Cyclooxygenase-2 Inhibition Restored Endothelium-Mediated Relaxation in Old Obese Zucker Rat Mesenteric Arteries

Metabolic syndrome is associated with reduced endothelial vasodilator function. It is also associated with the induction of cyclooxygenase-2 (COX2), which produces vasoactive prostanoids. The frequency of metabolic syndrome increases with age and aging per se is a risk factor associated with reduced endothelium-mediated relaxation. Nevertheless, the combined effect of aging and metabolic syndrome on the endothelium is less known. We hypothesized that COX2 derived prostanoids may affect endothelium function in metabolic syndrome associated with aging. We used obese Zucker rats, a model of metabolic syndrome. First order mesenteric arteries were isolated from 4- and 12-month-old rats and acetylcholine (endothelium)-dependent relaxation determined using wire-myography. Endothelium-mediated relaxation, impaired in young Zucker rats (89 versus 77% maximal relaxation; lean versus Zucker), was further reduced in old Zucker rats (72 versus 51%, lean versus Zucker). The effect of the nitric oxide-synthesis inhibitor L-NAME on the relaxation was reduced in both young and old Zucker rats without change in eNOS expression level. COX inhibition (indomethacin) improved acetylcholine-mediated relaxation in old obese rats only, suggesting involvement of vasoconstrictor prostanoids. In addition, COX2 inhibition (NS398) and TxA2/PGH2 receptor blockade (SQ29548) both improved relaxation in old Zucker rat arteries. Old Zucker rats had the highest TxB2 (TxA2 metabolite) blood level associated with increased COX2 immunostaining. Chronic COX2 blockade (Celecoxib, 3 weeks) restored endothelium-dependent relaxation in old Zucker rats to the level observed in old lean rats. Thus the combination of aging and metabolic syndrome further impairs endothelium-dependent relaxation by inducing an excessive production of COX2-derived vasoconstrictor(s); possibly TxA2

A rhenium tris-carbonyl derivative as a single core multimodal probe for imaging (SCoMPI) combining infrared and luminescent properties.

International audienceA rhenium tris-carbonyl derivative has been designed to couple infrared and luminescent detection in cells. Both spectroscopies are consistent with one another; they point out the reliability of the present SCoMPI (for Single Core Multimodal Probe for Imaging) for bimodal imaging and unambiguously indicate a localization at the Golgi apparatus in MDA-MB-231 breast cancer cells

In Utero Exposure to Maternal Diabetes Impairs Vascular Expression of Prostacyclin Receptor in Rat Offspring

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CHAPTER 3. Iron Compounds as Anticancer Agents

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Rapports des boursières 2011

Vessières-Jaouen Anne. Rapports des boursières 2011. In: Diplômées, n°242, 2012. Femmes créatrices d'entreprise. pp. 81-86

Commission des Bourses : Rapport d'activité 2014

Vessières-Jaouen Anne. Commission des Bourses : Rapport d'activité 2014. In: Diplômées, n°251, 2014. Les femmes : La Guerre et la Paix. pp. 226-230

Rapport de la Commission des Bourses 2015

Vessières-Jaouen Anne. Rapport de la Commission des Bourses 2015. In: Diplômées, n°255, 2015. pp. 126-128

Commission des Bourses

Vessières-Jaouen Anne. Commission des Bourses. In: Diplômées, n°239, 2011. Des femmes parlent de la modernité de l'archéologie. pp. 258-263

Commission des Bourses : Rapport d’activité 2013

Vessières-Jaouen Anne. Commission des Bourses : Rapport d’activité 2013. In: Diplômées, n°247, 2013. La prostitution étudiante. pp. 141-145