Implementation of the Entrepreneurship Capability Improvement Program in the Tourism Sector in Manado City

Tourism and entrepreneurship are related to strengthening the country's economy, income and community welfare. The growth of business actors in the tourism sector needs to continue to be improved in terms of quality and quantity. So various programs have been carried out by the government related to the implementation of programs to increase entrepreneurial abilities. Using a qualitative design, this research was conducted to examine the implementation of an entrepreneurial capacity building program in Manado City. Research findings show that the "human error" factor in business management and less innovative product quality are problems currently being faced. The Manado City Government, through Regional Work Units and in collaboration with the Central Government and the Private Sector, has implemented a program to increase entrepreneurial capacity in the form of socialization, training, mentoring, protection and provision of facilities. There has been an increase in the quantity of business actors but not yet in the quality of business management. Therefore, there needs to be good synergy between the government and business actors in supporting the tourism sector through entrepreneurial activities

Persepsi Masyarakat Tentang Kualitas Pelayanan Kesehatan di Rumah Sakit Umum Daerah Kota Kotamobagu Provinsi Sulawesi Utara

Liquid health services every effort held alone or together in an organizationto maintain and promote health, prevent and cure disease and restore the health ofindividuals, families, groups or communities. Looked at that hospital patientsshould be more capable in providing health services in the quest of healing andrestoration of quality, fast on the outside top of the complaints as well as theprovision of health services.This research uses qualitative research methods, descriptive, the number ofinformants will be interviewed in this study amounted to 8 (eight) theinformant; 1 person head of sub-division of The HOSPITALS of thecity of Kotamobagu, 1 Staff Officer, 6 people of the communitywho are receiving services (patient). Data collection techniques are in use;interview techniques, techniques of observation, and data collection techniques,with documents. The data analysis techniques in use; reduction of data,data presentation, and conclusion / verification of withdrawal

Efektivitas Pelaksanaan Program Nasional Pemberdayaan Masyarakat Mandiri Perkotaan di Kelurahan Ranotana Kota Manado

The problems of poverty are quite complex requiring the intervention of all parties together and coordinated. To improve the effectiveness of poverty reduction and job creation, the government launched the National Program for Community Empowerment (PNPM\u27s) began in 2007. The method used in this research is descriptive method with qualitative approach. A qualitative approach is used because researchers are planners, the interpreter of data / information, and in the end as well as a reporter research. This research was conducted in the village Ranotana Sario Manado District of focusing research on the effectiveness of the implementation of the National Program for Community Empowerment Urban. PNPM Mandiri is a national program to reduce poverty, especially that based on community empowerment. To improve the effectiveness of poverty reduction and job creation, the government launched the National Program for Community Empowerment began in 2007. The problems of poverty are quite complex requiring the intervention of all parties together and coordinated. To improve the effectiveness of poverty reduction and job creation, the government launched the National Program for Community Empowerment (PNPM) began in 2007. The method used in this research is descriptive method with qualitative approach. A qualitative approach is used because researchers are planners, the interpreter of data / information, and in the end as well as a reporter research. Based on the results of research and discussion, it can be concluded that the implementation of the National Program for Community Empowerment in Urban Village District of Sario Manado Ranotana not effectively be seen from the output or the amount issued results, level of satisfaction, creative products and intensity. In the determination of the action plan should involve not only the general public and government officials LKM village so that it can fit the needs of the community

Manajemen Keuangan Desa sebagai Faktor Penentu Keberhasilan Pembangunan Desa (Studi Kasus di Desa Kanonang Empat Kec. Kawangkoan Barat)

Management is a process of organization achievement by efforts from peoples.Management is a kind of special thought from leadership in order to attain the organization goals.The financial management of village is a factor who determined the successful of development andhelp process of the village development. Village financial is a rights and responsible in governmentorganized who can be valued with money included all the type of wealth who related with rightsand responsible of the village.Whereas who including the local government budget (LGB) village is the annual financialplanning of village government are investigated and approved together with the village governmentand LGB who determined by regulation of the village.Effectiveness in village financial process through good financial management system that willincrease the successful in village development. The organized of government village includeGovernment organized, Government affairs, and empowerment of villages communities.Village development is whole activities of development that run on village, include whole aspect ofthe entire citizen life that who operate in harmony with mutual cooperation. The Indicator ofsuccessful development village basically is a real repair in overall the life condition of society,because the construction is always a process of improvement of a state to a better state.Village development is a development that can be interpreted as a conscious efforts in aseries of activities to achieve a change from bad situation to better situation performed by a certainpeople in the country

A Class of Topological Actions

We review definitions of generalized parallel transports in terms of Cheeger-Simons differential characters. Integration formulae are given in terms of Deligne-Beilinson cohomology classes. These representations of parallel transport can be extended to situations involving distributions as is appropriate in the context of quantized fields.Comment: 41 pages, no figure

Arabidopsis annexin1 mediates the radical-activated plasma membrane Ca2+ - and K+ -permeable conductance in root cells

Plant cell growth and stress signaling require Ca2+ influx through plasma membrane transport proteins that are regulated by reactive oxygen species. In root cell growth, adaptation to salinity stress, and stomatal closure, such proteins operate downstream of the plasma membrane NADPH oxidases that produce extracellular superoxide anion, a reactive oxygen species that is readily converted to extracellular hydrogen peroxide and hydroxyl radicals, OH_. In root cells, extracellular OH_ activates a plasma membrane Ca2+-permeable conductance that permits Ca2+ influx. In Arabidopsis thaliana, distribution of this conductance resembles that of annexin1 (ANN1). Annexins are membrane binding proteins that can form Ca2+-permeable conductances in vitro. Here, the Arabidopsis loss-of-function mutant for annexin1 (Atann1) was found to lack the root hair and epidermal OH_-activated Ca2+- and K+-permeable conductance. This manifests in both impaired root cell growth and ability to elevate root cell cytosolic free Ca2+ in response to OH_. An OH_-activated Ca2+ conductance is reconstituted by recombinant ANN1 in planar lipid bilayers. ANN1 therefore presents as a novel Ca2+-permeable transporter providing a molecular link between reactive oxygen species and cytosolic Ca2+ in plants

Novel Tumor Suppressor Function of Glucocorticoid-Induced TNF Receptor GITR in Multiple Myeloma

Glucocorticoid-induced TNF receptor (GITR) plays a crucial role in modulating immune response and inflammation, however the role of GITR in human cancers is poorly understood. In this study, we demonstrated that GITR is inactivated during tumor progression in Multiple Myeloma (MM) through promoter CpG island methylation, mediating gene silencing in primary MM plasma cells and MM cell lines. Restoration of GITR expression in GITR deficient MM cells led to inhibition of MM proliferation in vitro and in vivo and induction of apoptosis. These findings were supported by the presence of induction of p21 and PUMA, two direct downstream targets of p53, together with modulation of NF-κB in GITR-overexpressing MM cells. Moreover, the unbalanced expression of GITR in clonal plasma cells correlated with MM disease progression, poor prognosis and survival. These findings provide novel insights into the pivotal role of GITR in MM pathogenesis and disease progression