54 research outputs found
Here and Nowhere.The Making of Urban Space
My interest is in the conscious role of space and time or of geography and history in contemporary urban development, particularly in the generation of urban projects. Can urban development be seen in relationship to form and thus to urban projects that are shaping and being shaped by contemporary culture? I would like to draw attention to a shift of attitude in a series of urban projects within the field of architecture and urbanism based on a ‘more fluid and kaleidoscopic socio-economic landscape’ that is characterised by programmatic indeterminacy and instability. This parallels a shift in society: The fragmenting of centralised flows of power towards the power of flows induced by networks that become the dominant social morphology (Castells 1996). I then introduce the notion of a material culture based on object form and the production and consumption of form through complex processes of negotiation. This negotiation of form is increasingly a conscious process on the level of configuration, a conceptual and diagrammatic level within the design process between the virtual and the real that allows interaction and participation. This in turn refers to the notion of the deleuzian abstract machines in cultural and historical processes and evolution in general. Geography has created GIS (Geographical Information Systems), a digital tool with which we within the diagrammatic process of configuration can create any map and map anything, an interface for participatory action. What is the historical equivalent of this tool, which are the generative engines of change over time and how are they configured
Improvement of Malignant Glioma Treatment: Preclinical evaluation of adenoviral gene therapy and PRRT
Glioblastoma multiforme (GBM) is the most aggressive type of malignant glioma
(WHO grade 4). Patients suffering from a GBM have a median survival of less than a
year after diagnosis despite the recent developments in neurosurgery, radiotherapy
and chemotherapy. This poor prognosis has led to the investigation of new treatment
modalities. Locoregional treatment modalities are potentially attractive for GBMs
because these tumors are generally confined to the central nervous system and
only rarely metastasize outside the nervous system. Examples of such locoregional
treatment modalities are gene therapy and peptide receptor radionuclide therapy
(PRRT).
As will be discussed in chapter 1.2, after successful gene therapy treatment
experiments in animal models, the clinical results of GBM gene therapy have been
disappointing, showing the need for improvement of this modality.
PRRT could also be beneficial for GBM patients since small radiolabeled peptide
molecules can migrate from the injection site to the tumor, and target to their corresponding
receptor on the cell membrane of these cells. At this moment, however,
it is not clear which peptide receptors are expressed on human GBM tissues.
The goal of this thesis was to identify bottlenecks limiting the efficacy of glioma
gene therapy using molecular imaging techniques. In addition, we explored the
possibility of PRRT treatment for GBM patients
Architectural and City-Planning Aspects of Innovation Hubs Formation in the Context of Creative Urban Regeneration (On the Case of Ukrainian Cities)
Preclinical animal research on therapy dosimetry with dual isotopes
Preclinical research into radionuclide therapies based on radiation dosimetry will enable the use of any LET-equivalent radionuclide. Radiation dose and dose rate have significant influence on dose effects in the tumour depending on its radiation sensitivity, possibilities for repair of sublethal damage, and repopulation during or after the therapy. Models for radiation response of preclinical tumour models after peptide receptor radionuclide therapy based on the linear quadratic model are presented. The accuracy of the radiation dose is very important for observation of dose-effects. Uncertainties in the radiation dose estimation arise from incomplete assay of the kinetics, low accuracy in volume measurements and absorbed dose S-values for stylized models instead of the actual animal geometry. Normal dose uncertainties in the order of 20% might easily make the difference between seeing a dose-effect or missing it altogether. This is true for the theoretical case of a homogeneous tumour type behaving in vivo in the same way as its cells do in vitro. Heterogeneity of tumours induces variations in clonogenic cell density, radiation sensitivity, repopulation capacity and repair kinetics. The influence of these aspects are analysed within the linear quadratic model for tumour response to radionuclide therapy. Preclinical tumour models tend to be less heterogenic than the clinical conditions they should represent. The results of various preclinical radionuclide therapy experiments for peptide receptor radionuclide therapy are compared to the outcome of theoretical models and the influence of increased heterogeneity is analysed when the results of preclinical research is transferred to the clinic. When the radiation dose and radiobiology of the tumour response is known well enough it may be possible to leave the current phenomenological approach in preclinical radionuclide therapy and start basing these experiments on radiation dose. Then the use of a gamma ray-emitting radionuclides for a chemically comparable beta-particle-emitting paired isotope for therapy evaluation would be feasible
Influence of tumour size on the efficacy of targeted alpha therapy with 213Bi-[DOTA0,Tyr3]-octreotate
Requirements regarding dose rate and exposure time for killing of tumour cells in beta particle radionuclide therapy
Why should I prepare? a mixed method study exploring the motives of medical undergraduate students to prepare for clinical skills training sessions
Learning more by being taught less: a “time-for-self-study” theory explaining curricular effects on graduation rate and study duration
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