43 research outputs found

    Anisotropy, multivalency and flexibility-induced effects in colloidal systems

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    We have studied the impact of particle shape anisotropy, multivalent interactions and flexibility on systems of micron-sized colloidal particles. In short, we have characterized the diffusive properties of anisotropic dumbbell particles near surfaces. Furthermore, by using experiments and simulations, we have uncovered marked flexibility-induces effects in the Brownian motion of reconfigurable colloidal structures. Our work demonstrates the rich dynamics and possibilities for applications of shape-changing colloidal systems. We hope our findings further the study of the diffusivity of flexible objects found in complex mixtures relevant in, for example, the cosmetic, pharmaceutical and food industries, as well as in biological and drug-delivery systems. For example, our results may have implications for understanding both the diffusive behavior and the most likely conformations of macromolecular systems such as polymers, single-stranded DNA and other chain-like molecules.Biological and Soft Matter Physic

    Bio-analytical Assay Methods used in Therapeutic Drug Monitoring of Antiretroviral Drugs-A Review

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    The CPLEAR detector at CERN

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    The CPLEAR collaboration has constructed a detector at CERN for an extensive programme of CP-, T- and CPT-symmetry studies using K0{\rm K}^0 and Kˉ0\bar{\rm K}^0 produced by the annihilation of pˉ\bar{\rm p}'s in a hydrogen gas target. The K0{\rm K}^0 and Kˉ0\bar{\rm K}^0 are identified by their companion products of the annihilation K±π{\rm K}^{\pm} \pi^{\mp} which are tracked with multiwire proportional chambers, drift chambers and streamer tubes. Particle identification is carried out with a liquid Cherenkov detector for fast separation of pions and kaons and with scintillators which allow the measurement of time of flight and energy loss. Photons are measured with a lead/gas sampling electromagnetic calorimeter. The required antiproton annihilation modes are selected by fast online processors using the tracking chamber and particle identification information. All the detectors are mounted in a 0.44 T uniform field of an axial solenoid of diameter 2 m and length 3.6 m to form a magnetic spectrometer capable of full on-line reconstruction and selection of events. The design, operating parameters and performance of the sub-detectors are described.
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