86 research outputs found
Aberration-free ultra-thin flat lenses and axicons at telecom wavelengths based on plasmonic metasurfaces
The concept of optical phase discontinuities is applied to the design and
demonstration of aberration-free planar lenses and axicons, comprising a phased
array of ultrathin subwavelength spaced optical antennas. The lenses and
axicons consist of radial distributions of V-shaped nanoantennas that generate
respectively spherical wavefronts and non-diffracting Bessel beams at telecom
wavelengths. Simulations are also presented to show that our aberration-free
designs are applicable to high numerical aperture lenses such as flat
microscope objectives
Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer’s disease
BACKGROUND: Treatment of mild-moderate Alzheimer’s disease (AD) subjects (N = 119) for 52 weeks with the SIRT1 activator resveratrol (up to 1 g by mouth twice daily) attenuates progressive declines in CSF Aβ40 levels and activities of daily living (ADL) scores. METHODS: For this retrospective study, we examined banked CSF and plasma samples from a subset of AD subjects with CSF Aβ42 <600 ng/ml (biomarker-confirmed AD) at baseline (N = 19 resveratrol-treated and N = 19 placebo-treated). We utilized multiplex Xmap technology to measure markers of neurodegenerative disease and metalloproteinases (MMPs) in parallel in CSF and plasma samples. RESULTS: Compared to the placebo-treated group, at 52 weeks, resveratrol markedly reduced CSF MMP9 and increased macrophage-derived chemokine (MDC), interleukin (IL)-4, and fibroblast growth factor (FGF)-2. Compared to baseline, resveratrol increased plasma MMP10 and decreased IL-12P40, IL12P70, and RANTES. In this subset analysis, resveratrol treatment attenuated declines in mini-mental status examination (MMSE) scores, change in ADL (ADCS-ADL) scores, and CSF Aβ42 levels during the 52-week trial, but did not alter tau levels. CONCLUSIONS: Collectively, these data suggest that resveratrol decreases CSF MMP9, modulates neuro-inflammation, and induces adaptive immunity. SIRT1 activation may be a viable target for treatment or prevention of neurodegenerative disorders. TRIAL REGISTRATION: ClinicalTrials.gov NCT0150485
Matrix metalloproteinases in the mouse retina: a comparative study of expression patterns and MMP antibodies
Serum matrix metalloproteinase-9 levels and severity of symptoms in boys with attention deficit hyperactivity disorder ADHD/hyperkinetic disorder HKD
Acute dysgrafie bij een voordien gezonde 33-jarige man : is er nog een indicatie voor de percutane sluiting van een patent foramen ovale?
Plasmonic Lenses Formed by Two-Dimensional Nanometric Cross-Shaped Aperture Arrays for Fresnel-Region Focusing
MR mammography in the pre-operative staging of breast cancer in patients with dense breast tissue: comparison with mammography and ultrasound
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