Introduction of Natural Oils into Rubber Compounds

In the rubber industry, plasticizers for rubber compounds mainly consist of petroleum derivatives. Consequently, the rubber industry is in constant competition with many petroleum consumers. This competition places an economic strain on rubber companies such as HEXPOL RUBBER COMPOUNDING L.L.C. In order to alleviate this strain, natural oil alternatives to petroleum plasticizers are of novel research interest and are investigated in this thesis project

Clinical significance of tumour-infiltrating B lymphocytes (TIL-Bs) in breast cancer: a systematic literature review

Although T lymphocytes have been considered the major players in the tumour microenvironment to induce tumour regression and contribute to anti-tumour immunity, much less is known about the role of tumour-infiltrating B lymphocytes (TIL-Bs) in solid malignancies, particularly in breast cancer, which has been regarded as heterogeneous and much less immunogenic compared to other common tumours like melanoma, colorectal cancer and non-small cell lung cancer. Such paucity of research could translate to limited opportunities for this most common type of cancer in the UK to join the immunotherapy efforts in this era of precision medicine. Here, we provide a systematic literature review assessing the clinical significance of TIL-Bs in breast cancer. Articles published between January 2000 and April 2022 were retrieved via an electronic search of two databases (PubMed and Embase) and screened against pre-specified eligibility criteria. The majority of studies reported favourable prognostic and predictive roles of TIL-Bs, indicating that they could have a profound impact on the clinical outcome of breast cancer. Further studies are, however, needed to better define the functional role of B cell subpopulations and to discover ways to harness this intrinsic mechanism in the fight against breast cancer

Evaluation of hip pain in older adults

The evaluation of hip pain in patients 65 years and older should include a history and physical examination, followed by pertinent imaging studies. (Strength of Recommendation [SOR]: C, based on expert opinion.) Patients who have hip pain for more than four weeks or who have concerning historical features, signs, or symptoms require hip imaging with radiography. There are no trials comparing the accuracy of magnetic resonance imaging (MRI), computed tomography (CT), and bone scintigraphy. MRI should be used in patients with suspected acute fracture in whom plain radiography does not yield a definitive diagnosis. (SOR: C, based on one small case series.) If MRI is contraindicated or unavailable, CT or bone scintigraphy can be substituted. (SOR: C, based on expert opinion.

Susceptibility of Fibromatosis Cells in Short-Term Culture to Ifosfamide: A Possible Experimental Treatment in Clinically Aggressive Cases

Purpose. Deep fibromatoses are large, often rapidly growing but benign soft tissue tumours. Although surgery is the mainstay of treatment, in unremitting and aggressive cases the use of cytotoxic chemotherapy may produce objective tumour responses. Fresh tumour samples from four patients with fibromatosis were investigated as part of a study of drug resistance in soft tissue tumours

Imatinib in gastrointestinal stromal tumour: Northern Cancer Network experience

Imatinib treatment in metastatic or inoperable gastrointestinal stromal tumours (GIST) has shifted the paradigm of treatment of this disease. Successful clinical trials of imatinib led to rapid regulatory approval and, in England and Wales, National Institute for Health and Clinical Excellence (NICE) guidance on use of this technology. NICE recommend detailed audit of their guidelines in clinical practice. This audit reflects that guidance and was designed to document the use of imatinib in routine clinical practice

Fume formation during black liquor droplet combustion: the importance of sodium release during devolatilization

"March 1992""Submitted to 1992 International Recovery Conference, June 7-11, 1992, Seattle, WA.

Arithmetic Spacetime Geometry from String Theory

An arithmetic framework to string compactification is described. The approach is exemplified by formulating a strategy that allows to construct geometric compactifications from exactly solvable theories at $c=3$. It is shown that the conformal field theoretic characters can be derived from the geometry of spacetime, and that the geometry is uniquely determined by the two-dimensional field theory on the world sheet. The modular forms that appear in these constructions admit complex multiplication, and allow an interpretation as generalized McKay-Thompson series associated to the Mathieu and Conway groups. This leads to a string motivated notion of arithmetic moonshine.Comment: 36 page

The significance of sodium release during devolatilization on fume formation in kraft recovery furnaces

"May 1993.""Submitted to Journal of Pulp and Paper Science.

Artificial intelligence in digital pathology: a roadmap to routine use in clinical practice

The use of artificial intelligence will likely transform clinical practice over the next decade and the early impact of this will likely be the integration of image analysis and machine learning into routine histopathology. In the UK and around the world, a digital revolution is transforming the reporting practice of diagnostic histopathology and this has sparked a proliferation of image analysis software tools. While this is an exciting development that could discover novel predictive clinical information and potentially address international pathology work-force shortages, there is a clear need for a robust and evidence-based framework in which to develop these new tools in a collaborative manner that meets regulatory approval. With these issues in mind, the NCRI Cellular Molecular Pathology (CM-Path) initiative and the British In Vitro Diagnostics Association (BIVDA) has set out a roadmap to help academia, industry and clinicians develop new software tools to the point of approved clinical use. This article is protected by copyright. All rights reserved. [Abstract copyright: This article is protected by copyright. All rights reserved.

Evaluation of Bovine Myosin Heavy Chain Isoforms and Muscle Fiber Cross-Sectional Area on the Eating Quality of 11 Different Beef Muscles

Objective: The objective of this study was to investigate the contribution of muscle fiber type and size on the eating quality of 11 different beef muscles. Study Description: Eleven different beef muscles were utilized from two separate studies. In study 1, shoulder clod, flank, knuckle, mock tender, top sirloin butt, brisket, eye of round, and ribeye were collected from 10 U.S. Department of Agriculture choice carcasses (n = 80), and each muscle was fabricated into steaks at 2 days postmortem. In study 2, strip loin, tri-tip, and heel were collected from 10 USDA low choice carcasses (n = 30). Myofibrillar proteins were extracted and analyzed by immunoblot to determine muscle fiber type. Cross sectional area (CSA) and muscle fiber diameter were determined under the microscope. An average of 400 fibers per sample were analyzed to determine CSA and muscle fiber diameter. Pearson correlation analysis was conducted to determine the relationship between muscle fiber type, CSA, and diameter with the results for the eating quality of beef as determined by a trained panel that were reported in previous studies. Results: In study 1, there was a positive correlation between fiber type 1 and initial juiciness (r = 0.37; P \u3c 0.05), sustained juiciness (r = 0.39; P \u3c 0.05) and lipid flavor (r = 0.41; P \u3c 0.05). Conversely, there was a negative correlation between fiber type 2A and initial juiciness (r = -0.40; P \u3c 0.05) sustained juiciness (r = -0.42; P \u3c 0.05), and lipid flavor (r = -0.45; P \u3c 0.01). Both studies saw a negative correlation between muscle fiber CSA and diameter with connective tissue content (P \u3c 0.05), but positive correlations to overall tenderness (P \u3c 0.05). The Bottom Line: This study shows that muscles predominated by type 1 fibers will likely deliver a higher eating quality experience for consumers, while muscles with more glycolytic fibers 2A and 2X will deliver a less favorable eating experience for consumers. On the other hand, these data also demonstrated that larger muscle fiber CSA and diameter are not necessarily a negative eating quality marker as muscles with those characteristics had less connective tissue and had greater tenderness scores