34 research outputs found
The ÎłTuRC Revisited: A Comparative Analysis of Interphase and Mitotic Human ÎłTuRC Redefines the Set of Core Components and Identifies the Novel Subunit GCP8
We compared the composition of Îł-tubulin ring complexes tandem-affinity purified from asynchronous and mitotic human cells by mass spectrometry. We identified various interactors including the novel core subunit GCP8. GCP8 is the first subunit with an interphase-specific role in centrosomal Îł-tubulin recruitment and microtubule nucleation