In silico estimates of the free energy rates in growing tumor spheroids

The physics of solid tumor growth can be considered at three distinct size scales: the tumor scale, the cell-extracellular matrix (ECM) scale and the sub-cellular scale. In this paper we consider the tumor scale in the interest of eventually developing a system-level understanding of the progression of cancer. At this scale, cell populations and chemical species are best treated as concentration fields that vary with time and space. The cells have chemo-mechanical interactions with each other and with the ECM, consume glucose and oxygen that are transported through the tumor, and create chemical byproducts. We present a continuum mathematical model for the biochemical dynamics and mechanics that govern tumor growth. The biochemical dynamics and mechanics also engender free energy changes that serve as universal measures for comparison of these processes. Within our mathematical framework we therefore consider the free energy inequality, which arises from the first and second laws of thermodynamics. With the model we compute preliminary estimates of the free energy rates of a growing tumor in its pre-vascular stage by using currently available data from single cells and multicellular tumor spheroids.Comment: 27 pages with 5 figures and 2 tables. Figures and tables appear at the end of the pape

X-ray Light Curves and Accretion Disk Structure of EX Hydrae

We present X-ray light curves for the cataclysmic variable EX Hydrae obtained with the Chandra High Energy Transmission Grating Spectrometer and the Extreme Ultraviolet Explorer Deep Survey photometer. We confirm earlier results on the shape and amplitude of the binary light curve and discuss a new feature: the phase of the minimum in the binary light curve, associated with absorption by the bulge on the accretion disk, increases with wavelength. We discuss several scenarios that could account for this trend and conclude that, most likely, the ionization state of the bulge gas is not constant, but rather decreases with binary phase. We also conclude that photoionization of the bulge by radiation originating from the white dwarf is not the main source of ionization, but that it is heated by shocks originating from the interaction between the inflowing material from the companion and the accretion disk. The findings in this paper provide a strong test for accretion disk models in close binary systems.Comment: 19 pages, 4 figures, accepted for publication in the Ap

Identification of Emission Lines in the Low-Ionization Strontium Filament Near Eta Carinae

We have obtained deep spectra from 1640 to 10100A with the Space Telescope Imaging Spectrograph (STIS) of the Strontium Filament, a largely neutral emission nebulosity lying close to the very luminous star Eta Carinae and showing an uncommon spectrum. Over 600 emission lines, both permitted and forbidden, have been identified. The majority originates from neutral or singly-ionized iron group elements (Sc, Ti, V, Cr, Mn, Fe, Co, Ni). Sr is the only neutron capture element detected. The presence of Sr II, numerous strong Ti II and V II lines and the dominance of Fe I over Fe II are notable discoveries. While emission lines of hydrogen, helium, and nitrogen are associable with other spatial structures at other velocities within the Homunculus, no emission lines from these elements correspond to the spatial structure or velocity of the Sr Filament. Moreover, no identified Sr Filament emission line requires an ionization or excitation energy above approximately 8 eV. Ionized gas extends spatially along the aperture, oriented along the polar axis of the Homunculus, and in velocity around the Strontium Filament. We suggest that the Strontium Filament is shielded from ultraviolet radiation at energies above 8 eV, but is intensely irradiated by the central star at wavelengths longward of 1500A.Comment: 28 pages, 5 figures, 4 tables. Accepted by A&A. High resolution pictures can be found at http://www.astro.lu.se/~henrikh/srpaper/srpaper.pd

Discovery of an ionized Fe-K edge in the z=3.91 Broad Absorption Line Quasar APM 08279+5255 with XMM-Newton

Recent XMM-Newton observations of the high-redshift, lensed, broad absorption line (BAL) quasi-stellar object APM 08279+5255, one of the most luminous objects in the universe, allowed the detection of a high column density absorber ($N_H \approx 10^{23}$ cm$^{-2}$) in the form of a K-shell absorption edge of significantly ionized iron (Fe XV - XVIII) and corresponding ionized lower-energy absorption. Our findings confirm a basic prediction of phenomenological geometry models for the BAL outflow and can constrain the size of the absorbing region. The Fe/O abundance of the absorbing material is significantly higher than solar (Fe/O = 2-5), giving interesting constraints on the gas enrichment history in the early Universe.Comment: 13 pages, 3 figures, 2 tables, ApJ (Letters), in pres

Radiative recombination data for modeling dynamic finite-density plasmas

We have calculated partial final-state resolved radiative recombination (RR) rate coefficients from the initial ground and metastable levels of all elements up to and including Zn, plus Kr, Mo, and Xe, for all isoelectronic sequences up to Na-like forming Mg-like. The data are archived according to the Atomic Data and Analysis Structure (ADAS) data class adf48, which spans a temperature range of z2(101-107) K, where z is the initial ion charge. Fits to total rate coefficients have been determined, for both the ground and metastable levels, and those for the ground are presented here. Comparison is made both with previous RR rate coefficients and with (background) R-matrix photoionization cross sections. This RR database complements a dielectronic recombination (DR) database already produced, and both are being used to produce updated ionization balances for both (electron) collisionally ionized and photoionized plasmas

The Very Highly Ionized Broad Absorption Line System of the QSO SBS1542+541

We have analyzed the broad absorption line system of the bright (V=16.5) high-redshift (z=2.361) QSO SBS1542+541 using UV spectra from the HST FOS along with optical data from the MMT and the Steward Observatory 2.3m telescope. These spectra give continuous wavelength coverage from 1200 to 8000 Angstroms, corresponding to 340 to 2480 Angstroms in the QSO rest frame. This object therefore offers a rare opportunity to study broad absorption lines in the rest-frame extreme UV. We find that the absorption system is dominated by very high-ionization species, including O VI, NeVIII, and SiXII. We also identify apparently saturated broad Lyman-series lines of order Ly-gamma and higher. There is strong evidence for partial occultation of the QSO emission source, particularly from the higher-order Lyman lines which indicate a covered fraction less than 0.2. Overall, the data suggest a correlation between a larger covered fraction and a higher state of ionization. We suggest that the different covered fractions can be explained by either a special line of sight through a disk-like geometry or by the existence of density fluctuations of a factor >2 in the BAL gas. Our photoionization models of the system indicate a large column density and high ionization state similar to that found in X-ray ``warm absorbers''.Comment: 31 pages, 13 figures, to be published in Ap

Broad P V Absorption in the BALQSO, PG 1254+047: Column Densities, Ionizations and Metal Abundances in BAL Winds

This paper discusses the detection of P V 1118,1128 and other broad absorption lines (BALs) in archival HST spectra of the low-redshift BALQSO, PG 1254+047. The P V identification is secured by excellent redshift and profile coincidences with the other BALs, such as C IV 1548,1550 and Si IV 1393,1403, and by photoionization calculations showing that other lines near this wavelength, e.g. Fe III 1123, should be much weaker than P V. The observed BAL strengths imply that either 1) there are extreme abundance ratios such as [C/H] >~ +1.0, [Si/H] >~ +1.8 and [P/C] >~ +2.2, or 2) at least some of the lines are much more optically thick than they appear. I argue that the significant presence of P V absorption indicates severe line saturation, which is disguised in the observed (moderate-strength) BALs because the absorber does not fully cover the continuum source(s) along our line(s) of sight. Computed optical depths for all UV resonance lines show that the observed BALs are consistent with solar abundances if 1) the ionization parameter is at least moderately high, log U >~ -0.6, 2) the total hydrogen column density is log N_H(cm-2) >~ 22.0, and 3) the optical depths in strong lines like C IV and O VI 1032,1038 are >~25 and >~80, respectively. These optical depths and column densities are at least an order of magnitude larger than expected from the residual intensities in the BAL troughs, but they are consistent with the large absorbing columns derived from X-ray observations of BALQSOs. The outflowing BALR, at velocities from -15,000 to -27,000 km/s in PG 1254+047, is therefore a strong candidate for the X-ray absorber in BALQSOs.Comment: 16 pages (LaTeX) plus 8 pages of figures in one file (pg1254_figs.ps.gz), in press with Ap

Eta Carinae -- Physics of the Inner Ejecta

Eta Carinae's inner ejecta are dominated observationally by the bright Weigelt blobs and their famously rich spectra of nebular emission and absorption lines. They are dense (n_e ~ 10^7 to 10^8 cm^-3), warm (T_e ~ 6000 to 7000 K) and slow moving (~40 km/s) condensations of mostly neutral (H^0) gas. Located within 1000 AU of the central star, they contain heavily CNO-processed material that was ejected from the star about a century ago. Outside the blobs, the inner ejecta include absorption-line clouds with similar conditions, plus emission-line gas that has generally lower densities and a wider range of speeds (reaching a few hundred km/s) compared to the blobs. The blobs appear to contain a negligible amount of dust and have a nearly dust-free view of the central source, but our view across the inner ejecta is severely affected by uncertain amounts of dust having a patchy distribution in the foreground. Emission lines from the inner ejecta are powered by photoionization and fluorescent processes. The variable nature of this emission, occurring in a 5.54 yr event cycle, requires specific changes to the incident flux that hold important clues to the nature of the central object.Comment: This is Chapter 5 in a book entitled: Eta Carinae and the Supernova Impostors, Kris Davidson and Roberta M. Humphreys, editors Springe

Physical conditions in the ISM towards HD185418

We have developed a complete model of the hydrogen molecule as part of the spectral simulation code Cloudy. Our goal is to apply this to spectra of high-redshift star-forming regions where H2 absorption is seen, but where few other details are known, to understand its implication for star formation. The microphysics of H2 is intricate, and it is important to validate these numerical simulations in better-understood environments. This paper studies a well-defined line-of-sight through the Galactic interstellar medium (ISM) as a test of the microphysics and methods we use. We present a self-consistent calculation of the observed absorption-line spectrum to derive the physical conditions in the ISM towards HD185418, a line-of-sight with many observables. We deduce density, temperature, local radiation field, cosmic ray ionization rate, chemical composition and compare these conclusions with conditions deduced from analytical calculations. We find a higher density, similar abundances, and require a cosmic ray flux enhanced over the Galactic background value, consistent with enhancements predicted by MHD simulations.Comment: 31 pages, accepted for publication in Ap