On the origin of bursts in blue compact dwarf galaxies: clues from kinematics and stellar populations

Blue compact dwarf galaxies (BCDs) form stars at, for their sizes, extraordinarily high rates. In this paper, we study what triggers this starburst and what is the fate of the galaxy once its gas fuel is exhausted. We select four BCDs with smooth outer regions, indicating them as possible progenitors of dwarf elliptical galaxies. We have obtained photometric and spectroscopic data with the FORS and ISAAC instruments on the VLT. We analyse their infrared spectra using a full spectrum fitting technique, which yields the kinematics of their stars and ionized gas together with their stellar population characteristics. We find that the stellar velocity to velocity dispersion ratio ((nu/sigma)(star)) of our BCDs is of the order of 1.5, similar to that of dwarf elliptical galaxies. Thus, those objects do not require significant (if any) loss of angular momentum to fade into early-type dwarfs. This finding is in discordance with previous studies, which however compared the stellar kinematics of dwarf elliptical galaxies with the gaseous kinematics of star-forming dwarfs. The stellar velocity fields of our objects are very disturbed and the star formation regions are often kinematically decoupled from the rest of the galaxy. These regions can be more or less metal rich with respect to the galactic body and sometimes they are long lived. These characteristics prevent us from pinpointing a unique trigger of the star formation, even within the same galaxy. Gas impacts, mergers, and in-spiraling gas clumps are all possible star formation igniters for our targets

Iron overload in polytransfused patients without heart failure is associated with subclinical alterations of systolic left ventricular function using cardiovascular magnetic resonance tagging

BACKGROUND: It remains incompletely understood whether patients with transfusion related cardiac iron overload without signs of heart failure exhibit already subclinical alterations of systolic left ventricular (LV) dysfunction. Therefore we performed a comprehensive evaluation of systolic and diastolic cardiac function in such patients using tagged and phase-contrast CMR. METHODS: 19 patients requiring regular blood transfusions for chronic anemia and 8 healthy volunteers were investigated using cine, tagged, and phase-contrast and T2* CMR. LV ejection fraction, peak filling rate, end-systolic global midventricular systolic Eulerian radial thickening and shortening strains as well as left ventricular rotation and twist, mitral E and A wave velocity, and tissue e' wave and E/e' wave velocity ratio, as well as isovolumic relaxation time and E wave deceleration time were computed and compared to cardiac T2*. RESULTS: Patients without significant iron overload (T2* > 20 ms, n = 9) had similar parameters of systolic and diastolic function as normal controls, whereas patients with severe iron overload (T2* 20 ms) or normal controls. Patients with moderate iron overload (T2* 10-20 ms, n = 5), had preserved ejection fraction (59 ± 6%, p = NS vs. pts. with T2* > 20 ms and controls), but showed reduced maximal LV rotational twist (1.8 ± 0.4 degrees). The magnitude of reduction of LV twist (r = 0.64, p < 0.001), of LV ejection fraction (r = 0.44, p < 0.001), of peak radial thickening (r = 0.58, p < 0.001) and of systolic (r = 0.50, p < 0.05) and diastolic twist and untwist rate (r = -0.53, p < 0.001) in patients were directly correlated to the logarithm of cardiac T2*. CONCLUSION: Multiple transfused patients with normal ejection fraction and without heart failure have subclinical alterations of systolic and diastolic LV function in direct relation to the severity of cardiac iron overload. Among all parameters, left ventricular twist is affected earliest, and has the highest correlation to log (T2*), suggesting that this parameter might be used to follow systolic left ventricular function in patients with iron overload

Orbital solutions derived from radial velocities and time delays for four {\it Kepler} systems with A/F-type (candidate) hybrid pulsators

The presence of A/F-type {\it Kepler} hybrid stars extending across the entire $\delta$ Sct-$\gamma$ Dor instability strips and beyond remains largely unexplained. In order to better understand these particular stars, we performed a multi-epoch spectroscopic study of 49 candidate A/F-type hybrid stars and one cool(er) hybrid object detected by the {\it Kepler} mission. We determined a lower limit of 27 % for the multiplicity fraction. For six spectroscopic systems, we also reported long-term variations of the time delays. For four systems, the time delay variations are fully coherent with those of the radial velocities and can be attributed to orbital motion. We aim to improve the orbital solutions for those systems with long orbital periods (order of 4-6 years) among the {\it Kepler} hybrid stars. The orbits are computed based on a simultaneous modelling of the RVs obtained with high-resolution spectrographs and the photometric time delays derived from time-dependent frequency analyses of the {\it Kepler} light curves. We refined the orbital solutions of four spectroscopic systems with A/F-type {\it Kepler} hybrid component stars: KIC 4480321, 5219533, 8975515 and KIC 9775454. Simultaneous modelling of both data types analysed together enabled us to improve the orbital solutions, obtain more robust and accurate information on the mass ratio, and identify the component with the short-period $\delta$ Sct-type pulsations. In several cases, we were also able to derive new constraints for the minimum component masses. From a search for regular frequency patterns in the high-frequency regime of the Fourier transforms of each system, we found no evidence of tidal splitting among the triple systems with close (inner) companions. However, some systems exhibit frequency spacings which can be explained by the mechanism of rotational splitting.Comment: 11 pages, 15 figures and 5 tables. Accepted for publication in A&

Biochemical Diagnosis of a Fatal Case of Günther’s Disease in a Newborn with Hydrops Foetalis

Peer Reviewe

Circulating MIR148A associates with sensitivity to adiponectin levels in human metabolic surgery for weight loss

Objective: We sought to discover secreted biomarkers to monitor the recovery of physiological adiponectin levels with metabolic surgery, focusing on epigenetic changes that might predict adiponectin function. Design: We conducted a prospective observational study of patients undergoing metabolic surgery by Roux-en-Y Gastric Bypass (RYGB) for weight loss in a single center (IRB GHS # 1207-27). Methods: All patients (n = 33; 27 females; 6 males) signed informed consent. Metabolites, adiponectin and MIR148A were measured in fasting plasma. We followed MIQE for transcript profiles. Results: Patients lost on average 47 ± 12% excess BMI (%EBMI) after 12 weeks. Adiponectin pre, post or delta (post minus pre) did not correlate with %EBMIL. A decrease in adiponectin following weight loss surgery was observed in a subset of patients, chi-square test of independence rejects the null hypotheses that the liver DNA methyltransferase 1 (DNMT1) and delta adiponectin are independent (chi-square statistics χ2 = 6.9205, P = 0.00852, n = 33), as well as MIR148A and delta adiponectin are independent (chi-square statistics χ2 = 9.6823, P = 0.00186, n = 33). The presence of plasma MIR148A allows identification of patients that appear to be adiponectin insensitive at baseline. Conclusion: We combined the presence of plasma MIR148A, the concentration of total adiponectin and the expression of DNA methyltransferase 1 (DNMT1) in liver biopsy tissue to identify patients with non-physiological adiponectin. Weight loss and physical activity interventions complemented with the new method presented here could serve to monitor the physiological levels of adiponectin, thought to be important for long-term weight loss maintenance

Times of Minima of 116 Eclipsing Binary Systems (2010-2015)

We present 201 times of CCD photometric minima collected from observing sites in Belgium and Greece during the years 2010 till 2015 for 116 eclipsing binary systems

Chemical Composition of Secondary Organic Aerosol Formed from the Photooxidation of Isoprene

Recent work in our laboratory has shown that the photooxidation of isoprene (2-methyl-1,3-butadiene, C5H8) leads to the formation of secondary organic aerosol (SOA). In the current study, the chemical composition of SOA from the photooxidation of isoprene over the full range of NO_x conditions is investigated through a series of controlled laboratory chamber experiments. SOA composition is studied using a wide range of experimental techniques:  electrospray ionization−mass spectrometry, matrix-assisted laser desorption ionization−mass spectrometry, high-resolution mass spectrometry, online aerosol mass spectrometry, gas chromatography/mass spectrometry, and an iodometric-spectroscopic method. Oligomerization was observed to be an important SOA formation pathway in all cases; however, the nature of the oligomers depends strongly on the NO_x level, with acidic products formed under high-NO_x conditions only. We present, to our knowledge, the first evidence of particle-phase esterification reactions in SOA, where the further oxidation of the isoprene oxidation product methacrolein under high-NO_x conditions produces polyesters involving 2-methylglyceric acid as a key monomeric unit. These oligomers comprise ∼22−34% of the high-NO_x SOA mass. Under low-NO_x conditions, organic peroxides contribute significantly to the low-NO_x SOA mass (∼61% when SOA forms by nucleation and ∼25−30% in the presence of seed particles). The contribution of organic peroxides in the SOA decreases with time, indicating photochemical aging. Hemiacetal dimers are found to form from C_5 alkene triols and 2-methyltetrols under low-NO_x conditions; these compounds are also found in aerosol collected from the Amazonian rainforest, demonstrating the atmospheric relevance of these low-NO_x chamber experiments