Description of six scenarios and of the results of six validated trials

Description of six scenarios and of the results of six validated trialsThis deliverable aims at presenting and analysing the processes of elaboration and validation of the PALETTE scenarios. After having defined these two processes and situated them into the PALETTE methodology, the scenarios are presented. For each scenario, the specific methodology of elaboration and validation is described with a special focus on the participation of the concerned Communities of Pratcice (CoPs). Then the results of the validation are presented as well as the reports of their technical feasability and the usability of PALETTE services from a user perspective. Finally we reflect on and we discuss about the whole process of validation of the scenarios and we describe the next steps towards the development of the scenarios and their trilas with the CoPs

À l'empereur d'Autriche / paroles de Frédérick Jannel. Les adieux d'un soldat à sa mère / paroles de Vermeulin

Comprend : Les adieux d'un soldat à sa mèreAvec mode text

PALETTE: User Centred Description of PALETTE tools and services and first analysis of usability

The present deliverable aims at providing any CoP member, CoP animator or CoP mediator with the most complete view of the PALETTE tools and services. It gives a voice to the developer, the educationalist, the ergonomist and of course the user to explain how they consider them. So, it suggests use cases, scenarios but also shows to the reader where are the obstacles of use (with the aim of avoiding a too quick discouragement on his/her part) and it provides real users’ testimonies. It illustrates the participative design, core of the project, by showing how various kinds of partners in the project work at their evolvement. Several times, it evokes how they interact in that way. More, for the sake of completeness, external services which are "social network" oriented, are described in terms of functionalities and with the concern of providing the audience with a largest view of how ICT may help CoPs to grow up.PALETTE : Pedagogically sustained Adaptive LEarning Through the exploitation of Tacit and Explicit knowledg

Are patients living far from hospital at higher risk of late adjuvant chemotherapy for colon cancer?

AimsLate adjuvant chemotherapy (aCT) administration after colectomy (>56 d) is known to be associated with impaired prognosis. We aim to identify risk factors associated with late aCT, especially the travel time between patients' home and hospital.MethodsWe performed a retrospective monocentre cohort study. Patients included had a colectomy for a stage III or high risk stage II colon cancer between 2009 and 2015 performed at a French university hospital. Risk factors for late aCT were identified using a fractional polynomial logistic regression.ResultsNinety-four patients were included. The risk of late aCT was associated with travel time length, emergent colectomy, the need for scheduled care before aCT, and length of time between colectomy and postoperative multidisciplinary meeting advising aCT.ConclusionOur study suggests that, in patients with colon cancer, factors unrelated to disease severity and complexity could be associated with a higher risk of late aCT

Totally implanted venous access-associated adverse events in oncology: Results from a prospective 1-year surveillance programme

International audienceDuring the last decade, most studies on totally implanted venous access-associated adverse events (TIVA-AE) were conducted retrospectively and/or were based on a limited sample size. The aim of our survey was two-fold: to estimate the incidence of TIVA-AE and to identify risk factors in patients with cancer

Copy number variations in DCC/ 18q and ERBB2/ 17q are associated with disease-free survival in microsatellite stable colon cancer

IF 5.531International audienceWe conducted a prospective study to assess the prognostic impact of selected copy number variations (CNVs) in stage II-III microsatellite stable (MSS) colon cancer. A total of 401 patients were included from 01/2004 to 01/2009. The CNVs in 8 selected target genes, DCC/18q, EGFR/7p, TP53/17p, BLK/8p, MYC/8q, APC/5q, ERBB2/17q, and STK6/20q, were detected using a quantitative multiplex polymerase chain reaction of short fluorescent fragment (QMPSF) method. The primary end-point was the impact of the CNVs on the 4-year disease-free survival (DFS). The recurrence rate at 4 years was 20.9%, corresponding to 14% stage II patients vs 31% stage III patients (p<0.0001). The 4-year DFS was significantly decreased in patients with a loss at DCC/18q (p=0.012) and a gain at ERBB2/17q (p=0.041). The multivariate analysis demonstrated that stage III, a loss at DCC/18q and a gain at ERBB2/17q were independent factors associated with DFS. A combination of DCC/18q and ERBB2/17q was also associated with relapse, with the hazard ratio increasing from 1 to 2.4 (95% confidence interval (CI), 1.5-4.1) and 3.1 (95% CI, 1.2-8.4) in the presence of 0, 1, or 2 alterations, respectively (p=0.0013). CNVs in DCC/18q and ERBB2/17q are significantly associated with DFS in stage II-III MSS colon cancer. This article is protected by copyright. All rights reserved

Description of six scenarios and of the results of six validated trials

Description of six scenarios and of the results of six validated trialsThis deliverable aims at presenting and analysing the processes of elaboration and validation of the PALETTE scenarios. After having defined these two processes and situated them into the PALETTE methodology, the scenarios are presented. For each scenario, the specific methodology of elaboration and validation is described with a special focus on the participation of the concerned Communities of Pratcice (CoPs). Then the results of the validation are presented as well as the reports of their technical feasability and the usability of PALETTE services from a user perspective. Finally we reflect on and we discuss about the whole process of validation of the scenarios and we describe the next steps towards the development of the scenarios and their trilas with the CoPs