Dynamic Thermal Analysis of a Power Amplifier

This paper presents dynamic thermal analyses of a power amplifier. All the investigations are based on the transient junction temperature measurements performed during the circuit cooling process. The presented results include the cooling curves, the structure functions, the thermal time constant distribution and the Nyquist plot of the thermal impedance. The experiments carried out demonstrated the influence of the contact resistance and the position of the entire cooling assembly on the obtained results.Comment: Submitted on behalf of TIMA Editions (http://irevues.inist.fr/tima-editions

Systems-level characterization of ovarian cancer metabolism

The purpose of this thesis was to characterize cancer metabolism in vitro using epithelial ovarian cancer as a model on an untargeted, systems-level, basis with particular attention paid to the difference between cancer stem cell metabolism and cancer cell metabolism. Two-dimensional gas chromatography coupled to mass spectrometry was used to measure the metabolite profiles of the ovarian cancer and cancer stem cell lines under normal baseline conditions and also under chemotherapeutic and environmental perturbations. These two cell lines exhibited significant metabolic differences under normal baseline conditions and results demonstrated that metabolism in the ovarian cancer stem cell line was distinct from that of more differentiated isogenic cancer cells, showing similarities to stem cell metabolism that suggest the potential importance of metabolism for the cancer stem cell phenotype. Glucose deprivation, hypoxia, and ischemia all perturbed ovarian cancer and cancer stem cell metabolism, but not in the same ways between the cell types. Chemotherapeutic treatment with docetaxel caused metabolic changes mostly in amino acid and carbohydrate metabolism in ovarian cancer cells, while ovarian cancer stem cell metabolism was not affected by docetaxel. Overall, these metabolic differences between the two cell types will deepen our understanding of the metabolic changes occurring within the in vivo tumor and will help drive development of cancer stem cell targeted therapeutics.Ph.D

Therapists’ Willingness to Access Client Social Media Accounts in the Context of Suicide Risk

The past two decades has seen a proliferation of social media use, leading to a growing body of research on the potential utility for clinical contexts. In the current study, we examine willingness of psychologists to utilize client social media to inform suicide risk-assessment and risk-related treatment decisions, and the ethical principles they used to guide their considerations. Participants were asked of the likelihood they would engage in 1) a social media-informed risk assessment, where the therapist uses client social media to inform their initial determination of risk level, and 2) a digital welfare check, where the therapist accesses an at-risk client\u27s social media page to determine if they are in immediate danger and require further protective measures. Participants’ likelihood of engaging in these behaviors was assessed using two fictional clinical vignettes. The ethical principles they used in their deliberations were assessed using the General Ethical Principles Questionnaire, in which participants rated the relative contribution of each general ethical principle (Beneficence and Nonmaleficence, Respect for Peoples\u27 Rights and Dignity, Integrity, Justice, and Fidelity and Responsibility) to their responses on the vignettes. Therapist factors including professional status (licensed vs. in-training), digital literacy, and theoretical orientation were examined in terms of how they influenced likelihood ratings for each vignette. Overall, most participants reported being unlikely to engage in either a social media-informed risk assessment or a digital welfare check. Results also indicated participants were more likely to conduct a digital welfare check than a social media-informed risk assessment. Interestingly, relative value placed on Beneficence positively predicted likelihood to engage in both forms of social media checks, and Respect for Peoples’ Rights and Dignity negatively predicted likelihood to engage in a digital welfare check, but not a social media-informed risk assessment. Professional status, digital literacy and identification with any specific theoretical orientation did not predict likelihood to engage in either form of therapist accessing clients’ social media. We conclude with a discussion of how psychologists can effectively and ethically incorporate social media into their practice and potential implications for the development of future ethical standards and guidelines related to digital practice