Quercetin 3 Rutinoside Alleviates Chromosomes Instability Induced by Lethal Dose of Gamma Radiation

Radiation-induced genomic instability always remains a major concern for the medical society, following radiation exposure. Hence, development of a safe and effective radioprotector is of considerable interest in case of radiotherapy and radiation emergencies. Quercetin-3-Rutinoside (Q-3-R), a naturally occurring bioflavonoid, has shown promising potential against radiation injuries. The present study reports anti-genotoxic potential of Q-3-R against lethal (9Gy) dose of ionizing radiation. The mice were injected intramuscularly with Q-3-R (10mg/kg b.wt.), 1hr prior to lethal dose of radiation and dissected at 24hrs post treatment. Different kinds of chromosomal aberrations, micronuclei as well as pulverized metaphase and polyploidy were scored in bone marrow cells. Irradiated mice showed significantly (p<0.001) increased number of double minutes, fragments, dicentrics, rings, gaps and end to end association. Pulverized metaphases and polyploidy were also found to be elevated in irradiated group. Pretreatment of Q-3-R significantly countered these radiation-induced genetic variations in lethally exposed mice. Data from the present study support the anti-genotoxic potential of Q-3-R even at lethal dose of radiation. Q-3-R, possessing various pharmacological activities and being a safe supplement for treatment of other ailments, can be further explored for its radioprotective potential

Terminal Area Conflict Detection and Resolution Tool

This poster will describe analysis of a conflict detection and resolution tool for the terminal area called T-TSAFE. With altitude clearance information, the tool can reduce false alerts to as low as 2 per hour

Quercetin 3 Rutinoside Facilitates Protection Against Radiation Induced Genotoxic and Oxidative Damage A Study in C57bl 6 Mice

Radiation-induced oxidative stress and haematopoietic genomic instability is the major concern during planned or unplanned exposure. Use of the natural phytochemicals is an emerging strategy to prevent from the harmful effects of radiation. In the current investigation, Quercetin 3-Rutinoside (Q-3-R), a polyphenolic bioflavonoid, has been evaluated against gamma radiation (2Gy) induced genotoxic damage and oxidative imbalance in mice. Mice were administered with Q-3-R (10mg/kg body weight) 1hr prior to irradiation and evaluated for its antioxidant potential. Anti-genotoxic potential was assessed in terms of chromosomal aberrations in bone marrow cells. Findings revealed that Q-3-R had very high reducing potential, effectively scavenged 1,1-Diphenyl-2-picryl hydrazyl (DPPH) and hydrogen peroxide radicals, chelated metal ions and inhibited lipid peroxidation in a dose dependant manner. The glutathione (GSH) levels were found elevated (p<0.05), while reduced malondialdehyde (MDA) levels were seen in blood and liver tissues of Q-3-R pretreated mice. Significant (p<0.01) reduction in Reactive Oxygen Species (ROS) levels and radiation induced aberrations (dicentrics, rings, fragments, end to end association, robertsonian translocation) following Q-3-R pretreatment was found in bone marrow cells. The present findings demonstrate that Q-3-R can effectively minimise radiation-induced genotoxic and oxidative damages and can be explored further to be used as a potent radioprotector in humans

Effect of UV Exposure on Coir-epoxy Infused Particulate Composite

Photo degradation mainly occurs in the lignin which is responsible for the colour changes. The surface becomes richer in cellulose content as the lignin degrades. In contrast to lignin, cellulose is much less prone to UV degradation. The effect of accelerated UV-aging on properties of coir-epoxy infused particulate composites has been studied. Composites are prepared by the hand layup technique at room temperature (25°C). Composites containing 15%particulates were subjected to accelerate UV-aging in a QUV weatherometer for 24 hrs. The results showed that coir-epoxy infused particulate composites displayed good UV resistance with regard to mechanical properties. The color of the coir-epoxy infused particulate composite changed from dark brown to light brown at the exposed area because of the formation of a thin, strongly degraded surface layer. Differential scanning calorimetry (DSC), X-ray diffraction (XRD), thermogravimetric analysis (TGA) and scanning electron microscopy (SEM) were also carried out to assess the changes occurring during accelerated weathering. These results show the deterioration of the epoxy matrix leading to crystallization. A decrease in epoxy melting temperature was also noted, due to molecular chain scission and the formation of extraneous groups, such as carbonyls and amine

Efficacy and safety of different terbinafine regimens in patients of recurrent tinea corporis and cruris

Background: Tinea corporis and cruris is said to be recurrent when there is relapse of sign and symptoms after 6 weeks of cure. Recently, there has been increase in cases of recurrent tinea corporis and cruris, with atypical lesions. This study was done to establish efficacy and safety of different terbinafine regimens against recurrent tinea corporis and cruris.Methods: Sixty patients with clinically and mycologically diagnosed recurrent tinea corporis and cruris were enrolled and divided into three groups. Group A was administered oral terbinafine 500 mg once daily for 2 weeks, group B was given terbinafine 250 mg once daily for double duration i.e., 4 weeks, and group C was given standard treatment which is 250 mg once daily for 2 weeks. Physician assessment four-point scale (PA4PS) and KOH wet mount were assessed for clinical and mycological efficacy. Biochemical laboratory parameters (liver function tests and kidney function tests) and adverse drug reactions were assessed for safety.Results: At the end of 6 weeks, reduction in PA4PS from baseline was 46.5%, 95.8%, and 20.4% in groups with double dose, double duration and standard therapy respectively with statistically significant (p<0.05) improvement in group with double duration. Mycological cure at the end of 4 weeks was 80%, 100% and 50%. There was no safety concern in any of the groups.Conclusions: Double duration of terbinafine was found to be more efficacious and safer

Methods to Reduce Communication Workload for UAM Operations

Implementation of Urban Air Mobility (UAM) operations, or air passenger transportation systems within densely populated metropolitan areas, seeks to mitigate increasing traffic congestion. However, the development and integration of UAM operations into the national airspace system comes with its own unique challenges, such as vehicle requirements, flight planning and scheduling, and coordination between UAM flights and air traffic controllers. In particular, verbal coordination will play an integral part in the determined success of UAM operations and its ability to meet projected high consumer demands. In order to meet demands and higher traffic volumes on UAM routes, verbal communication between the UAM pilot and controller must be streamlined to reduce the controller's workload while helping to maintain safety within a given airspace. One method of reducing verbal workload are Letters Of Agreement (LOAs) that outline responsibilities and procedures for operations in an airspace. These LOAs will specify the operations, procedures, and routes for UAM flights. The proposed study will examine the usability of two route formatting styles for LOAs; (i) Verbal route descriptions and (ii) Tower En Route Control (TECs) routes. Verbal route descriptions will include the route name and associated visual cues on the route. The TEC route versions will include relevant waypoints and charts outlining the route with waypoints marked. The study will be part of a UAM X1 human in the loop (HITL) simulation. Controller participants will handle traditional air traffic including moderate levels of UAM traffic on current and modified helicopter routes within the Dallas Fort-Worth area. Scenarios will be counterbalanced and repeated to test both route formatting versions. After each trial, participants will rate the usability of the LOA used in the previous trial via a subjective questionnaire. We expect that controllers will prefer the LOA with TEC routes due to simplicity and visual elements available

Atracurium-induced anaphylaxis and angioedema: a case report

Drug-induced anaphylaxis has increased in frequency with the more widespread use of pharmaceutical agents. Neuromuscular blocking agents (NMBAs) are one of the most common causes of anaphylaxis during general anesthesia. However, the incidence of anaphylaxis due to atracurium is very rare (<1/10,000) according to UK Summary of Product Characteristics. NMBAs can induce two types of reactions: one is immune mediated - immunoglobulin E dependent and the second one is associated with non-specific stimulation of mast cells. Systemic manifestations of anaphylaxis can be in the form of hypotension, difficulty in breathing. Rarely, it can be associated with cutaneous manifestations such as urticaria, angioedema, and flushing. If it is not promptly diagnosed and treated, it can be fatal. In the present case, the patient was posted for submandibular gland surgery. She was well-stabilized after general anesthesia and within the seconds of giving injection atracurium; she had difficulty in breathing and marked decrease in blood pressure that was soon followed by periorbital swelling and swelling of lips. The patient was diagnosed with anaphylaxis with angioedema due to atracurium and was promptly managed in operation theater. She was kept under observation for 2 days. Anaphylaxis along with angioedema with atracurium is a very rare event, and hence it is being reported here

TSTR HITL Results

This briefing presents the summary and results of the ATD-2 HITL #2, Tactical Surface Tool for Ramp (TSTR). The original presentation was completed in Aug 2016

Assessment of water quality around coal-fired thermal power plant, Bathinda (Punjab), India

In the present study, both the underground and surface water samples around Guru Nanak Dev Thermal Power Plant Bathinda, Punjab, having total installed capacity of 440MW, were analyzed for the physico-chemical parameters viz. pH, Electrical Conductivity (EC), Total Dissolved Solid (TDS), Total Hardness (TH), Calcium (Ca2+), Magnesium (Mg2+), Total Alkalinity (TA), Carbonate (CO32-), Bicarbonate (HCO3-), Chloride (Cl-), Phosphate (PO43-), Nitrate (NO3-), Fluoride (F-) and heavy metals such as Cadmium (Cd), Copper (Cu), Lead(Pb), Nickel (Ni) and Zinc (Zn). The correlation coefficients (r) among various water quality parameters of studied underground water samples were calculated. The physical and chemical parameters of groundwater are compared with the drinking water quality standards recommended by Bureau of Indian Standards (BIS) (2012) and World Health Organization (WHO) (2017). On the basis of results obtained in the present study, concentration of Chloride (Cl-), Magnesium (Mg2+), Fluoride (F-) and Total&nbsp; dissolved solids (TDS) observed in ground water of Bathinda varied from 30 to 284 mg/l, 120 to 280 mg/l, 2.66-3.99 mg/l and 620-1439 mg/l, respectively which are exceeding the acceptable limits prescribed by WHO (2017) as well as BIS (2012). Also, the concentration of heavy metals viz. cadmium (0.366 to 0.437 mg/l), and lead (0.193 to 0.353 mg/l) have higher levels than prescribed by WHO and BIS for drinking purpose. Thus, groundwater is not suitable for drinking purposes with prior treatment