Sturen op nitraat: waar zitten de knoppen?

Bemesting, beweiding en scheuren van grasland hebben een groot effect op de nitraatconcentratie in het grondwater. Op maïsland heeft het achterwege laten van kunstmest, maar ook het achterwege laten van de bemesting van het vanggewas, behoorlijk effect. Dit blijkt uit een analyse van melkveebedrijven op zandgronden in het project Koeien & Kansen. De analyse omvat de effecten van bedrijfsvoering en van bodem, waterhuishouding en weer op de nitraatconcentrati

Compounded laxative formulations for substituting phenolphthalein with sennosides A & B in solid dosage forms

Purpose: Following the discovery of the carcinogenicity of phenolphthalein and the subsequent ban of this compound in several countries this study was undertaken to develop compounded formulations of laxative products containing the stimulant laxatives sennosides A and B. Methods: DSC and HPLC analysis was used to determine the compatibility of sennosides with commonly used excipients before compounding capsules, tablets and effervescent tablets containing sennosides A & B. The physical and chemical stability and release properties of these dosage forms were determined for 12 weeks at increased temperature and relative humidity. Results: Sennosides A & B were compatible with a wide variety of powdered excipients. However, these were incompatible with propyl paraben, sodium carbonate, stearic acid, citric acid, PEG, and sugar derivatives such as lactose, glucose and sorbitol when granulated with water. Not withstanding these interactions, it was possible to compound simple capsule, tablet and even an effervescent tablet formulations containing sennosides A & B that complied with pharmacopeial specifications. However, all these formulations were sensitive to moisture because when stored at increased temperature and relative humidity, disintegration times increased and dissolution rates decreased. Conclusion: Based on compatibility and stability studies simple, stable and elegant solid dosage forms containing sennosides A & B were compounded that can be used to replace phenolphthalein in a variety of solid dosage forms. Keywords: Compounding; Sennosides A & B; Phenolphthalein replacement; Drug-Excipient Compatibility > Tropical Journal of Pharmaceutical Research Vol. 3 (1) 2004: pp. 265-27

How can student teachers elicit experienced teachers' practical knowledge? Tools, suggestions and significance

Wetensch. publicatieICLO

A stochastic network with mobile users in heavy traffic

We consider a stochastic network with mobile users in a heavy-traffic regime. We derive the scaling limit of the multi-dimensional queue length process and prove a form of spatial state space collapse. The proof exploits a recent result by Lambert and Simatos which provides a general principle to establish scaling limits of regenerative processes based on the convergence of their excursions. We also prove weak convergence of the sequences of stationary joint queue length distributions and stationary sojourn times.Comment: Final version accepted for publication in Queueing Systems, Theory and Application

Professionele ontwikkeling van leraren:een reviewstudie naar effectieve kenmerken van professionaliseringsinterventies van leraren

Reviewstudie in opdracht van en gesubsidieerd door NWO-PROO (Grant no. 441-080353