Felderítő robotok

Az odometria, vagyis lépésszámlálásos navigácós módszer, bemutatása. Egy olyan kalibrációs rendszer felépítése, amellyel a kalibrált robot hatékonysága nagyban növekszik.Bs

Coeliac disease: from triggering factors to treatment

Coeliac disease (CD) or gluten sensitive enteropathy is one of the most common inflammatory diseases of the small intestine with estimated prevalence of 1% in the population. Its incidence is increasing and seems to be higher than expected in the pediatric population associated with unfavorable impact on the quality of life. The aim of the present review is to highlight the main triggering factors leading to the development of CD and its pathomechanism with a special outlook to the recent therapeutic approaches

Colour of Stone Slabs under Different Standard Illuminations

Spectral measurements have been carried out on polished stone slabs to show the accuracy of theoretical colorimetric calculations on perceptual differences of color appearance under various standard illuminations. Effects of the different spectral characteristics of the light source on colorization of the samples have been also studied to analyze the changes of color sensation on the samples in connection with the changes on the type of the illuminating source. Solar light (Standard Illuminant D65), basic incandescent source (Standard Illuminant A) and a basic fluorescent source (Standard Illuminant F11) have been tested on Tardos red limestone, Siklós green limestone, Carrara white and gray marbles and diorite samples. Colorizing effects of the examined illuminations are compared to Standard Illuminant E – the theoretically perfect white source

Involvement of heat shock proteins in gluten-sensitive enteropathy

Gluten-sensitive enteropathy, also known as coeliac disease (CD), is an autoimmune disorder occurring in genetically susceptible individuals that damages the small intestine and interferes with the absorption of other nutrients. As it is triggered by dietary gluten and related prolamins present in wheat, rye and barley, the accepted treatment for CD is a strict gluten-free diet. However, a complete exclusion of gluten-containing cereals from the diet is often difficult, and new therapeutic strategies are urgently needed. A class of proteins that have already emerged as drug targets for other autoimmune diseases are the heat shock proteins (HSPs), which are highly conserved stress-induced chaperones that protect cells against harmful extracellular factors. HSPs are expressed in several tissues, including the gastrointestinal tract, and their levels are significantly increased under stress circumstances. HSPs exert immunomodulatory effects, and also play a crucial role in the maintenance of epithelial cell structure and function, as they are responsible for adequate protein folding, influence the degradation of proteins and cell repair processes after damage, and modulate cell signalling, cell proliferation and apoptosis. The present review discusses the involvement of HSPs in the pathophysiology of CD. Furthermore, HSPs may represent a useful therapeutic target for the treatment of CD due to the cytoprotective, immunomodulatory, and anti-apoptotic effects in the intestinal mucosal barrier

Role of the Microbiome in Celiac Disease

Microbiome is the community of commensal, symbiotic and pathogenic microorganism that share our human body space. Intestinal microbiota has a defensive role in human health, it is implicated in metabolic and nutritional processes and plays an important role in the pathophysiology of several diseases. In recent years special attention has been paid to investigations targeting the changes of intestinal microbiome in various gastrointestinal disorders including inflammatory bowel disease, infectious colitis and celiac disease (CD). The aim of our present review is to summarize the role of the microbiome in CD and the changes of its composition in the intestine of patients suffering from CD

Neutron-gazdag atommagok Coulomb-felbomlási folyamatai dinamikájának vizsgálata = Investigation of the dynamics of Coulomb-breakup of neutron-rich nuclei

A kutatómunka egy megfelelően kiválasztott magreakció vizsgálatának segítségével kívánt következtetni a neutron-gazdag atommagok Coulomb-felbomlási folyamatainak részleteire. A Michigan-i Állami Egyetemen lévő Nemzeti Szupravezető Ciklotron Laboratórium K-1200 gyorsítója mellett kísérletet hajtottunk végre 70 és 40 MeV/u energiájú radioaktív 8Li nyalábbal ólom és szén céltárgyakon, amelyben a bombázó részecske 7Li-re és neutronra való felbomlását figyeltük meg. A 7Li fragmentumot mágnessel térítettük az erre a célra kifejlesztett iondetektor-rendszerbe, a neutronokat a repülési-idő technikával detektáltuk. A több bonyolult részfeladat megoldása után minden megfigyelt bomlásra meghatároztuk a felbomló 8Li izotóp, valamint a felhasadáskor keletkezett neutron és 7Li ion impulzusát. A szén targeten végrehajtott kísérlet lehetővé tette, hogy a Coulomb- és a nukleáris felbomlást mindkét bombázó energiánál az ólomtargettel mért adatoknál elválasszuk. Az eredményekből a 8Li Coulomb-felbomlása hatáskeresztmetszetét meghatároztuk a bomlási energia függvényében. Az előzetes eredmények szerint a 8Li felbomlási hatáskeresztmetszete összhangban van a 7Li(n,?)8Li inverz reakció korábban kísérletileg meghatározott hatáskeresztmetszetével. Kísérleti eredményeink lehetővé teszik a 8Li Coulomb-felbomlásának ütközési paraméter szerinti vizsgálatát és a felbomlási folyamatoknak a két különböző bombázó energiánál való összehasonlítását. Az eredmények véglegesítése és publikálása folyamatban van. | The research work focused on the details of Coulomb-breakup processes of neutron-rich nuclei by means of the investigation of a selected nuclear reaction. Experiments have been performed on lead and carbon targets with 8Li beams of 70 and 40 MeV/u energies at the K-1200 cyclotron of NSCL at Michigan State University. The breakup of 8Li ions into neutrons and 7Li ions was observed. The 7Li fragments were deflected by a sweeper magnet into a detector system. The neutrons from the breakup processes were detected by time-of-flight technique. The evaluation of the experimental data required the development of several sophisticated methods. In the analysis of the data the momenta of the incoming 8Li ion and that of both decay products, the 7Li and the neutron were determined for each detected event. The use of the data for the carbon target made it possible to separate the Coulomb and nuclear part of the decay in the case of the lead target. The cross sections for the neutron breakup of 8Li were determined as the function of the decay energy. According to the preliminary results, the breakup cross section of 8Li is in accordance with the experimentally determined cross section of the inverse reaction 7Li(n,?)8Li. The results of the measurements make it possible to investigate the Coulomb-breakup of 8Li as a function of the impact parameter and the comparison of the breakup processes at the two bombarding energy. The publications of the results are in progress

Role of IL-24 in the mucosal remodeling of children with coeliac disease

Background Recently, involvement of IL-19, IL-20 and IL-24 has been reported in inflammatory diseases associated with tissue remodeling. However, their impact on the pathomechanism of coeliac disease (CD) is still completely unknown. Methods Expression of IL19, IL20 and IL24 was measured by real-time RT-PCR, protein amount of IL-24, α smooth muscle actin (α-SMA) and fibronectin (FN) was determined by Western-blot analysis in the duodenal biopsies of therapy naive children with CD and controls. Localization of IL-24 and IL-20RB was investigated by immunofluorescent staining in the duodenal mucosa. Effect of recombinant IL-1β, TNF-α, TGF-β and IL-17 treatment on the expression of IL19, IL20, IL24 and their receptors was investigated by real-time RT-PCR in small intestinal epithelial cells (FHs74Int), in primary duodenal myofibroblasts (pdMFs) and in peripheral blood mononuclear cells (PBMCs). Effect of IL-24 on H2O2 treated FHs74Int cells and on pdMFs was measured by MTT, LDH, Annexin V assays, real-time RT-PCR and by fluorescent microscopy. Results We found increased level of IL-24 (3.3×, p < 0.05), α-SMA (2.4×, p < 0.05) and FN (2.3×, p < 0.05) in the duodenal mucosa and increased expression of IL19 (3.6×, p < 0.05) and IL24 (5.2×, p < 0.05) in the PBMCs of children with CD compared to that of controls. IL-1β was a strong inducer of IL24 expression of FHs74Int cells (9.9×, p < 0.05), pdMFs (552.9×, p < 0.05) or PBMCs (17.2×, p < 0.05), as well. IL-24 treatment reduced the number of apoptotic cells (0.5×, p < 0.05) and decreased the expression of inflammatory factors, including IL1A, IL6 and TNF of H2O2-treated FHs74Int cells. IL-24 decreased the proliferation (0.6×, p < 0.05) of PDGF-B treated pdMFs. Moreover, IL-24 treatment altered the morphology of pdMFs by influencing the size of the angles between stress fibers and the longitudinal axis of the cells (2.0×, p < 0.05) and the expression of cytoskeletal components, including ACTA2, ACTB, VIM, SNAI1 and SNAI2. Conclusion Our results suggest that IL-24 plays a significant role in the maintenance of duodenal mucosal integrity in CD