Autoimmune diseases related to anti-N-methyl-D-aspartate receptor encephalitis, a descriptive study in a third level center

Background: Epiphenomena in neurological disorders can lead to subsequent autoimmune diseases such as autoimmune encephalitis (AE), but research on this condition is limited. There is a lack of knowledge about the development of autoimmune diseases in AE patients due to its rarity. The objective of this study is to investigate the association between the development of autoimmune diseases and patients with anti-NMDA autoimmune encephalitis. Methods: A cross-sectional study was conducted from 2015 to 2022 at UMAE La Raza Antonio Fraga Mouret to investigate the relationship between autoimmune diseases and anti-NMDA AE. 194 patients were tested for anti-NMDA antibodies in cerebrospinal fluid (CSF), and 50 were found to meet the criteria for AE based on clinical, laboratory, and imaging tests. Follow-up evaluations assessed for rheumatological diseases and various additional tests were conducted before and after the AE event. The study was approved by the ethical and investigation committee. Results: Our analysis included 50 patients with autoimmune encephalitis. Of these, 62% were women aged 18-51 years (mean age 31.97 years) and 38% were men aged 19-72 years (mean age 39.2 years). Fifty-two percent of patients had positive antibodies for autoimmune diseases, but only 12% met ACR criteria for autoimmune disease. The CSF was negative for infections. Electroencephelography (EEG) showed abnormalities in 42% of patients, and Magnetic resonance imaging (MRI) showed hyperintensity in the medial temporal lobes, cortico-subcortical regions, and white matter. False positives were excluded. Conclusions: Among patients with autoimmune encephalitis, 12% had associated autoimmune diseases, most of which developed after the diagnosis of encephalitis. The observed diseases were 3 cases of lupus, 1 of rheumatoid arthritis, 1 of thyroiditis, and 1 of vasculitis. There is an epiphenomenal relationship between autoimmune encephalitis and subsequent development of autoimmune diseases

Internal Migration in Mexico in the year 2000.

This study, based on the Census sample of 2000, sought to identify permanent internal migratory flows: people settled in a geographical entity different from that in which they were born. The aim was to establish the volume of migration and the characteristics of the localities (birth and residence) and, at the same time, provide interpretations of these phenomena within some established theoretical frameworks. Methodologically, the principal flows of migration between states of the Republic were established and correlated with the size of the localities to which migrants are attracted. It was found that, the age groups and genders of migrants are reinterpreted, as are their choice of destinations, to give a picture of internal migration different from that suggested in general models, especially those originating in the first world. The role of women in migration in Mexico seems particularly important. A new interpretation of the migration of children is suggested

Migración interna en México, Datos de la muestra censal de 2010 (pdf)

Datos de la muestra censal de 2010 con información sobre migración interna de los estados del país con datos y estadísticas del comportamiento de diversas variables involucradas en el estudio del fenómeno migratorio interno de la República Mexicana, en particular, dos de sus principales: edad y sexo, con cuadros, gráficas y matriz de flujos migratorios entre las 32 entidades federativas del país

Migración interna en México

posean los componentes biodemográficos (natalidad y mortalidad) y la intensidad de la movilidad espacial de los habitantes. El estudio de esta última es particularmente complejo; por una parte, se trata de un fenómeno multidimensional que cuenta con tres dimensiones básicas: residencia, tiempo y espacio. Una de las razones por las que el entendimiento del proceso de movilidad espacial se ha dificultado es la tendencia a no hacer distinciones importantes en cada una de estas dimensiones, denominando con el término migración a diversos desplazamientos de la población.Migración interna en México. Datos de la muestra censal de 2010 es el segundo libro que se publica con información sobre migración interna de los estados del país. El primero fue publicado en 2005 por El Colegio Mexiquense y lleva por título: Dinámica migratoria interestatal en la República Mexicana, cuyas fuentes de información fueron las generadas por el Instituto Nacional de Estadística y Geografía (INEGI), en particular el xii Censo general de población y vivienda y la muestra censal del 2000. Con la difusión de los datos del xiii Censo de población y vivienda en el primer semestre de 2011, y posteriormente con la publicación de la base de datos de la muestra censal 2010, es posible hacer estudios del fenómeno migratorio interno de la República Mexicana a partir de su regularidad estadística. En la búsqueda de regularidades en el estudio de la migración interna, destacan en la producción teórica demográfica Ernest Ravenstein (1885, 1889) y Everett Lee (1966). Sobre el pensamiento científico acerca de la migración se puede decir que despues de la propuesta de Ravenstein, hasta ahora, no se identifican avances sustanciales en su conocimiento; como por ejemplo, los alcanzados en la teoría de las poblaciones estables de Alfred Lotka (1969)

Autoimmune post-COVID vaccine syndromes: Does the spectrum of autoimmune/inflammatory syndrome expand

To date, around 60% of the world population has been protected by vaccines against SARS-CoV-2, significantly reducing the devastating effect of the pandemic and restoring social economic activity through mass vaccination. Multiple studies have demonstrated the effectiveness and safety of vaccines against COVID-19 in healthy populations, in people with risk factors, in people with or without SARS-CoV-2 infection, and in immunocompromised people. According to the criteria for post-vaccine adverse events established by the World Health Organization, a minority of individuals may develop adverse events, including autoimmune syndromes. The exact mechanisms for the development of these autoimmune syndromes are under study, and to date, a cause-effect relationship has not been established. Many of these autoimmune syndromes meet sufficient criteria for the diagnosis of Adjuvant-Induced Autoimmune Syndrome (ASIA syndrome). The descriptions of these autoimmune syndromes open new perspectives to the knowledge of the complex relationship between the host, its immune system, with the new vaccines and the development of new-onset autoimmune syndromes. Fortunately, most of these autoimmune syndromes are easily controlled with steroids and other immunomodulatory medications and are short-lived. Rheumatologists must be alert to the development of these autoimmune syndromes, and investigate the relationship between autoimmune/inflammatory symptoms and vaccination time, and assess their therapeutic response

Immune-Neuroendocrine Interactions and Autoimmune Diseases

The relationship between immune-neuroendocrine system is firmly established. The messengers of this connection are hormones, neuropeptides, neurotransmitters and cytokines. The immune-neuroendocrine system have the capacity to synthesize and release these molecules, which, in turn, can stimulate or suppress the activity of immune or neuroendocrine cells by binding to receptors. In fact, hormones, neuropeptides and neurotransmitters participate in innate and adaptive immune response

In response to comment on "Autoimmune post-COVID vaccine syndromes: Does the spectrum of autoimmune/inflammatory syndrome expand?" by Jara LJ et al

We thank Dr. Kunal Chandwar for their interest in our article “Autoimmune post-COVID vaccine syndromes: does the spectrum of autoimmune/infammatory syndrome expand?” Indeed, we have included all of the COVID-19 vaccines, and we agree with you that they have diferent mechanisms of action but similar capabilities to protect against COVID19 to millions of people. Therefore, they also can induce adverse effects, including autoimmune syndromes, in a minority of people with genetic and environmental risk factors

TEORÍA DE LA MIGRACIÓN. UN ESTUDIO APLICADO EN NAYARIT

Este es un trabajo de tipo demográfico que se fundamenta en la teoría propuesta por Everett Lee (Lee, 1966), a partir de ésta se verifican dos hipótesis. La primera de ellas establece que el volumen de la migración dentro de un determinado territorio varía con el grado de la diversidad de las áreas incluidas en dicho territorio; y la segunda, que la mayor propensión a migrar en ciertas etapas del ciclo de vida es un factor importante en la selección del migrante. La evidencia empírica proviene de dos fuentes de información del Instituto Nacional de Estadística y Geografía: los datos censales del 2010 y la muestra censal del mismo año. El fenómeno migratorio interno ha sido poco estudiado en Nayarit por ello en esta investigación nos propusimos analizar sus intercambios migratorios con el resto del país. Además introdujimos en este estudio la categoría de tamaño de localidad en el análisis de las estructuras por edad y sexo de la población migrante

Historic evolution of State of Mexico’s population

The State of Mexico has been redefining its area at different times in its history as well as the size and composition of its population, which also has been modified when its territorial limits has been established. In this paper, the changes experienced by the population of the State in the course of its history are identified, the growth of its population and its distribution is analyzed by age since 1871, when its territory was bounded to the limits currently held, until 2010.El Estado de México ha visto redefinir su extensión territorial en diversos momentos de su historia y, con ello, el tamaño y la composición de su población, modificadas al establecerse las mensiones territoriales que ocupa actualmente. En este trabajo se identifican las variaciones que ha experimentado la población del Estado en el transcurso de su historia; se analiza el recimiento de su población y su distribución por edad desde 1871, año en que su territorio quedó acotado a los límites que conserva hasta el año 2010

Product, process and resource model coupling for knowledge-driven assembly automation

: Accommodating frequent product changes in a short period of time is a challenging task due to limitations of the contemporary engineering approach to design, build and reconfigure automation systems. In particular, the growing quantity and diversity of manufacturing information, and the increasing need to exchange and reuse this information in an efficient way has become a bottleneck. To improve the engineering process, digital manufacturing and Product, Process and Resource (PPR) modelling are considered very promising to compress development time and engineering cost by enabling efficient design and reconfiguration of manufacturing resources. However, due to ineffective coupling of PPR data, design and reconfiguration of assembly systems are still challenging tasks due to the dependency on the knowledge and experience of engineers. This paper presents an approach for data models integration that can be employed for coupling the PPR domain models for matching the requirements of products for assembly automation. The approach presented in this paper can be used effectively to link data models from various engineering domains and engineering tools. For proof of concept, an example implementation of the approach for modelling and integration of PPR for a Festo test rig is presented as a case study