La \uabfredda\ubb e \uaballegra\ubb impostura dell\u2019abate Vella nella Palermo settecentesca

Il saggio delinea una geniale impostura che occup\uf2 la scena palermitana di fine Settecento seguendo la ricostruzione di uno storico ottocentesco, Domenico Scin\ue0, e la sua riscrittura in un romanzo di Leonardo Sciascia. Un solo protagonista, l\u2019abate Vella, nel testo dello storico; due personaggi, il Vella e il Di Blasi, nel "Consiglio d\u2019Egitto" (1963). Scin\ue0, in uno scritto del 1824, presenta l\u2019abate Vella come un avventuriero e ripercorre l'impostura grazie alla quale egli aveva costruito dal nulla una falsa storia della Sicilia, tutta orientata a rafforzare e ampliare prerogative e diritti della monarchia contro le appropriazioni, ritenute indebite, dei grandi feudatari. Nel romanzo storicamente fedele \ue8 la ricostruzione dell\u2019impostura, rigorosamente storici e reali sono i personaggi, tutta sciasciana (nel senso che ci si ritrova l\u2019ideologia, a volte l\u2019ironia, spesso lo sconforto dell\u2019autore) \ue8 l\u2019invenzione narrativa che presiede alla scrittura dei monologhi, dei dialoghi, alla ricostruzione delle situazioni, degli ambienti che fanno da sfondo alle vicende, elementi questi ultimi necessari per costruire \uabil vero romanzesco\ubb. Alla fine, prendendo spunto dall\u2019inganno velliano, altre falsificazioni, altre imposture si materializzeranno nel romanzo: supreme quelle della storia, della scrittura, dei libri e, quindi, della letteratura; \uabtragica\ubb quella della congiura giacobina palermitana del 1795 e del suo fallimento

A Novel Technique for Laryngotracheal Reconstruction for Idiopathic Subglottic Stenosis

Idiopathic subglottic stenosis is the most challenging condition in the field of upper airway reconstruction. We describe a successful novel technique for enlarging the airway space at the site of the laryngotracheal anastomosis in very high-level reconstructions

Effect of NF-κB/Rel inhibition on spontaneous vs chemotherapy-induced apoptosis in AML and normal cord blood CD34+ cells

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Partial purification and MALDI-TOF MS analysis of UN1, a tumor antigen membrane glycoprotein.

UN1 is a membrane glycoprotein that is expressed in immature human thymocytes, a subpopulation of peripheral T lymphocytes, the HPB acute lymphoblastic leukemia (ALL) T-cell line and fetal thymus. We previously reported the isolation of a monoclonal antibody (UN1 mAb) recognizing the UN1 protein that was classified as "unclustered" at the 5th and 6th International Workshop and Conference on Human Leukocyte Differentiation Antigens. UN1 was highly expressed in breast cancer tissues and was undetected in non-proliferative lesions and in normal breast tissues, indicating a role for UN1 in the development of a tumorigenic phenotype of breast cancer cells. In this study, we report a partial purification of the UN1 protein from HPB-ALL T cells by anion-exchange chromatography followed by immunoprecipitation with the UN1 mAb and MALDI-TOF MS analysis. This analysis should assist in identifying the amino acid sequence of UN

Policies and reporting guidelines for small biopsy specimens of mediastinal masses

目前，胸腺恶性肿瘤治疗方案大多是根据术\ud 后病理确定，然而，多数临床治疗决策需要在术前\ud 通过活检小标本的病理报告来制定。所以，术前活\ud 检小标本的正确获取和病理解读对治疗决策的制定\ud 显得非常重要[1]。这些标本包括细针活检标本，带\ud 芯穿刺活检标本和手术切取活检标本[2-7]。由于胸\ud 腺肿瘤的病理诊断对组织的获取方法和获取量都有较高\ud 的要求，加之对病理的描述也没有统一的标准，使得小\ud 标本在诊断胸腺瘤方面存在诸多问题。为此，ITMIG在\ud 病理科医生和外科医生回顾相关文献和提出初步建议的\ud 基础上，经集体讨论制定了活检规范操作流程，提出了\ud 对纵隔肿物小活检标本处理和病理报告的建议。旨在为\ud 术前患者的治疗提供一个统一和具有循证医学证据的方\ud 法；同时，将有利于全球数据之间的比较和开展合作研\ud 究，充分利用医疗资源

Long-term results of laryngotracheal resection for benign stenosis from a series of 109 consecutive patients

OBJECTIVES: Long-term results of patients undergoing laryngotracheal resection for benign stenosis are reported. This is the largest series ever published. METHODS: Between 1991 and March 2015, 109 consecutive patients (64 males, 45 females; mean age 39 ± 10.9 years) underwent laryngotracheal resection for subglottic postintubation (93) or idiopathic (16) stenosis. Preoperative procedures included tracheostomy in 35 patients, laser in 17 and laser plus stenting in 18. The upper limit of the stenosis ranged between actual involvement of the vocal cords and 1.5 cm from the glottis. Airway resection length ranged between 1.5 and 6 cm (mean 3.4 ± 0.8 cm) and it was over 4.5 cm in 14 patients. Laryngotracheal release was performed in 9 patients (suprahyoid in 7, pericardial in 1 and suprahyoid + pericardial in 1). RESULTS: There was no perioperative mortality. Ninety-nine patients (90.8%) had excellent or good early results. Ten patients (9.2%) experienced complications including restenosis in 8, dehiscence in 1 and glottic oedema requiring tracheostomy in 1. Restenosis was treated in all 8 patients with endoscopic procedures (5 laser, 2 laser + stent, 1 mechanical dilatation). The patient with anastomotic dehiscence required temporary tracheostomy closed after 1 year with no sequelae. One patient presenting postoperative glottic oedema underwent permanent tracheostomy. Minor complications occurred in 4 patients (3 wound infections, 1 atrial fibrillation). Definitive excellent or good results were achieved in 94.5% of patients. Twenty-eight post-coma patients with neuropsychiatric disorders showed no increased complication and failure rate. CONCLUSIONS: Laryngotracheal resection is the definitive curative treatment for subglottic stenosis allowing very high success rate at long term. Early complications can be managed by endoscopic procedures achieving excellent and stable results over time

Activation of NF-kappaB/Rel transcription factors in human primary peripheral blood mononuclear cells by interleukin 7.

Pathways that regulate the activation of NF-kappaB/Rel transcription factors are known to include signaling through a number of cytokine receptors. Interleukin 7 (IL-7), produced by bone marrow and other stromal cells, is a key factor for differentiation and survival in the lymphoid and other compartments. We found that human recombinant IL-7 induced NF-kappaB/Rel activation, analyzed by electrophoretic mobility shift assay (EMSA), in human peripheral blood T lymphocytes from healthy donors. Induced complexes included p65 and p50 NF-kappaB/Rel subunits. These results demonstrate for the first time that IL-7 can participate in signaling leading to NF-kappaB/Rel activation

Deep venous thrombosis and abortion: an unusual clinical manifestation of severe form of pectus excavatum

Pectus excavatum is a chest wall malformation with a strong psychological and aesthetic impact. Rarely, pectus excavatum patients can show respiratory or cardiac symptoms occurring mainly during physical exertion. We report a case of a 34-year-old pregnant woman with a severe degree of pectus excavatum who developed serious cardiovascular disease resulting in spontaneous twin abortion at the twenty-first week of gestation. Cardiovascular disease was resolved after open surgical correction of pectus excavatum. This case shows how a tardive diagnosis and a delayed surgical approach for pectus excavatum can lead to severe consequences

Lung cancer surgery in octogenarians: a meta-analysis of predictors for postoperative complications

Background: Recently, several reports had focused on the feasibility of lung cancer surgery in octogenarians, describing encouraging short and long-term survival. However, the postoperative complication rate remains high. Some papers analyzed the role of potential predictors of post-operative complications, showing discordant results. We aimed at systematically assessing the evidence on risk factors for post-operative complications in octogenarians undergoing lung cancer surgery. Methods: Literature search was performed through PubMed and MEDLINE using the terms “lung cancer”, “non-small cell lung cancer” or “lung cancer surgery” combined with “octogenarian” or “80 years”. Last search was performed on 03/2021. Inclusion criteria were: clinical studies involving octogenarians undergoing lung cancer surgery between 1990 and 2020; studies explicitly appraising risk factors for postoperative complications and providing adjusted risk effect estimates. Studies that did not explicitly investigate predictors of postoperative complications and papers published in other language than English were not included. Risk of bias was assessed using the Quality in Prognostic Factor Studies (QUIPS) tool. More than 20 potential predictors were screened, finally limiting the inferential analysis to the six most frequently reported: performance status (PS), forced expiratory volume in 1 second (FEV1), type of resection, surgical approach, history of tobacco abuse and male gender. Adjusted P values from individual studies were pooled with the Fisher method. A pooled 2-tailed P value ≤0.05 was considered statistically significant. Results: A final set of 13 cohort studies, including 2,596 patients, was considered. Effect estimates were reported for PS by 6 studies (46%), for FEV1 by 10 (77%), for type of resection by 11 (85%), for surgical approach by 4 (31%), for history of tobacco abuse by 6 (46%), and for male gender by 8 (62%). After inferential analysis with the Fisher method, a significant association with post-operative complications was found for PS (P=0.004), major resections (P=0.002) and open approach (P=0.007); male gender showed only a borderline trend (P=0.053). Preoperative FEV1 (P=0.109) and history of tobacco abuse (P=0.399) were not associated with increased postoperative complications. Conclusions: Lung cancer surgery in octogenarian patients represent a viable and useful treatment. According to our analysis, patients should be carefully selected considering that a good preoperative PS is associated with a lower rate of postoperative complications. Similarly, thoracoscopic approach and sublobar resection should be preferred in octogenarian patients if technically and oncologically sound. Interestingly, impaired lung function was not significantly associated to post-operative complications