602 research outputs found
Interactive exploration of population scale pharmacoepidemiology datasets
Population-scale drug prescription data linked with adverse drug reaction
(ADR) data supports the fitting of models large enough to detect drug use and
ADR patterns that are not detectable using traditional methods on smaller
datasets. However, detecting ADR patterns in large datasets requires tools for
scalable data processing, machine learning for data analysis, and interactive
visualization. To our knowledge no existing pharmacoepidemiology tool supports
all three requirements. We have therefore created a tool for interactive
exploration of patterns in prescription datasets with millions of samples. We
use Spark to preprocess the data for machine learning and for analyses using
SQL queries. We have implemented models in Keras and the scikit-learn
framework. The model results are visualized and interpreted using live Python
coding in Jupyter. We apply our tool to explore a 384 million prescription data
set from the Norwegian Prescription Database combined with a 62 million
prescriptions for elders that were hospitalized. We preprocess the data in two
minutes, train models in seconds, and plot the results in milliseconds. Our
results show the power of combining computational power, short computation
times, and ease of use for analysis of population scale pharmacoepidemiology
datasets. The code is open source and available at:
https://github.com/uit-hdl/norpd_prescription_analyse
Analysis and study of hospital communication via social media from the patient perspective
Currently, the online interaction between citizens and hospitals is poor, as
users believe that there are shortcomings that could be improved. This study
analyzes patientsâ opinions of the online communication strategies of hospitals in
Spain. Therefore, a mixed-method is proposed. Firstly, a qualitative analysis through
a focus-group was carried out, so around twenty representatives of national,
regional and local patientsâ associations were brought together. Secondly, the
research is supplemented with a content assessment of the Twitter activity of the
most influential hospitals in Spain. The results reveal that the general public
appreciate hospitalsâ communication potential through social media, although they
are generally unaware of how it works. The group says that, apart from the lack of
interaction, they find it hard to understand certain messages, and some publications
give a biased picture. In order to improve communication, patients and
relatives are demanding that their perspective be taken into consideration in the
messages issued to enhance the quality of life and well-being of society
Emerging methods in therapeutics using multifunctional nanoparticles
Clinical translation of nanoparticleâbased drug delivery systems is hindered by an array of challenges including poor circulation time and limited targeting. Novel approaches including designing multifunctional particles, cellâmediated delivery systems, and fabrications of proteinâbased nanoparticles have gained attention to provide new perspectives to current drug delivery obstacles in the interdisciplinary field of nanomedicine. Collectively, these nanoparticle devices are currently being investigated for applications spanning from drug delivery and cancer therapy to medical imaging and immunotherapy. Here, we review the current state of the field, highlight opportunities, identify challenges, and present the future directions of the next generation of multifunctional nanoparticle drug delivery platforms.This article is categorized under:BiologyâInspired Nanomaterials > Protein and VirusâBased StructuresNanotechnology Approaches to Biology > Nanoscale Systems in BiologyNovel approaches in designing nanoparticles to overcome challenges faced by traditional nanoparticleâbased drug delivery systems.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/155963/1/wnan1625.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/155963/2/wnan1625_am.pd
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