14 research outputs found
Viscous Dusty Fluid Flow with Constant Velocity Magnitude
We consider the viscous dusty fluid, where the velocity of the dust particle is everywhere parallel to that of the fluid with velocity magnitude of the fluid is constant along each individual streamline. Also it is assumed that number density of the dust particle is constant and the dust particles are uniform in size and shape and bulk concentration of the dust is small. Hodograph and Legendre transform of stream function is employed to get the solutions and the geometry of streamlines for these flows by using the resulting partial differential equations when the Jacobian is zero and nonzero cases. In each case the variation of pressure is analyzed graphicall
Flexural properties of areca nut, sunn hemp and e-glass fibers reinforced with epoxy composites
Study of Mechanical, Thermal, and Rheological Properties of Areca Fiber-Reinforced Polyvinyl Alcohol Composite
A New Series of Orally Bioavailable Chemokine Receptor 9 (CCR9) Antagonists; Possible Agents for the Treatment of Inflammatory Bowel Disease
Chemokine
receptor 9 (CCR9), a cell surface chemokine receptor
which belongs to the G protein-coupled receptor, 7-trans-membrane
superfamily, is expressed on lymphocytes in the circulation and is
the key chemokine receptor that enables these cells to target the
intestine. It has been proposed that CCR9 antagonism represents a
means to prevent the aberrant immune response of inflammatory bowel
disease in a localized and disease specific manner and one which is
accessible to small molecule approaches. One possible reason why clinical
studies with vercirnon, a prototype CCR9 antagonist, were not successful
may be due to a relatively poor pharmacokinetic (PK) profile for the
molecule. We wish to describe work aimed at producing new, orally
active CCR9 antagonists based on the 1,3-dioxoisoindoline skeleton.
This study led to a number of compounds that were potent in the nanomolar
range and which, on optimization, resulted in several possible preclinical
development candidates with excellent PK properties
Thioredoxin/thioredoxin reductase system involvement in cerebellar granule cell apoptosis
The involvement of thioredoxin/thioredoxin reductase system has been investigated in cerebellar granule cells (CGCs), a cellular system in which neurons are induced in apoptosis by the physiological stimulus of lowering extracellular potassium. Clarifying the sequence of events that occur during apoptosis is a critical issue as it can lead to the identification of those key events that, if blocked, can slow down or reverse the death process. The results reported in this work show that TrxR is involved in the early phase of CGC apoptosis with an increase in activity that coincides with the increased expression of the TrxR1 isoform and guarantees the maintenance of adequate level of Trx in its reduced, active form. However, in late apoptosis, when about 50 % of cells are dead, partial proteolysis of TrxR1 by calpain occurs and the reduction of TrxR1 mRNA, together with the overall decrease in TrxR activity, contribute to increase the levels of the oxidized form of Trx. When the reduced form of Trx is externally added to apoptotic cultures, a significant reduction in cell death is achieved confirming that a well-functioning thioredoxin/thioredoxin reductase system is required for survival of CGCs