A multimodal study of augmented reality in the architectural design studio

Architectural design representations comprise physical (models, drawings) and digital media (3D models). Multimodal combinations of physical and digital representations are commonplace in professional contexts such as design reviews or building sites, and ‘making sense’ of these assemblies requires complex socio-cognitive processes and professional expertise. In that context, this paper follows a ‘sense-making’ approach, and theorises the impact of multimodal representations in architectural design tutorials. Hybrid physical/digital representations have been built using Augmented Reality (AR) and utilised in dialogues between students’ groups and design tutors. Design tutorials have been documented through video, workshops, observational notes and interviews to generate a grounded theory through iterative and reflexive coding. Following a multimodal approach, the paper frames AR as an enabler and mediator of design communication, evidenced through multimodal choreographies of physical/digital media, speech and the individual and collective performances of participants’ bodies and actions in space. The resulting theory is composed of 7 concepts outlining the impact of AR in multimodal architectural communication, including the major constructs ‘AR-mediated Interaction’ and ‘Augmented Pedagogies’. The paper outlines this conceptual taxonomy and provides fieldwork evidence supporting a methodological shift from technology-focused to sense-making observations of technology in design activity

Conception rate of artificially inseminated holstein cows affected by cloudy vaginal mucus, under intense heat conditions.

The objective of this work was to obtain prevalence estimates of cloudy vaginal mucus in artificially inseminated Holstein cows raised under intense heat, in order to assess the effect of meteorological conditions on its occurrence during estrus and to determine its effect on conception rate. In a first study, an association was established between the occurrence of cloudy vaginal mucus during estrus and the conception rate of inseminated cows (18,620 services), raised under intense heat (mean annual temperature of 22°C), at highly technified farms, in the arid region of northern Mexico. In a second study, data from these large dairy operations were used to assess the effect of meteorological conditions throughout the year on the occurrence of cloudy vaginal mucus during artificial insemination (76,899 estruses). The overall rate of estruses with cloudy vaginal mucus was 21.4% (16,470/76,899; 95% confidence interval = 21.1?21.7%). The conception rate of cows with clean vaginal mucus was higher than that of cows with abnormal mucus (30.6 vs. 22%). Prevalence of estruses with cloudy vaginal mucus was strongly dependent on high ambient temperature and markedly higher in May and June. Acceptable conception rates in high milk-yielding Holstein cows can only be obtained with cows showing clear and translucid mucus at artificial insemination.Título em português: Taxa de concepção de vacas Holandesas inseminadas artificialmente e afetadas por muco vaginal turvo, sob condições de intenso calor

Vitamin A and marbling attributes: Intramuscular fat hyperplasia effects in cattle

© 2017 Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/Twenty Angus steers were fed a diet low in β-carotene and vitamin A for 10 months. Ten steers were supplemented with vitamin A weekly, while the other ten steers did not receive any additional vitamin A. The results demonstrated that the restriction of vitamin A intake increased intramuscular fat (IMF) by 46%. This was a function of the total number of marbling flecks increasing by 22% and the average marbling fleck size increasing by 14%. Vitamin A restriction resulted in marbling flecks that were less branched (22%) and slightly more round (4%) with an increased minor axis length (7%). However, restricting vitamin A did not affect the size of the intramuscular or subcutaneous adipocyte cells or the subcutaneous fat depth. The results suggest that vitamin A affects the amount of marbling and other attributes of the marbling flecks due to hyperplasia rather than hypertrophy. This may explain why vitamin A restriction specifically affects IMF rather than subcutaneous fat deposition

Staff perceptions towards virtual reality-motivated treadmill exercise for care home residents: a qualitative feedback study with key stakeholders and follow-up interview with technology developer

Objectives Health and care resources are under increasing pressure, partly due to the ageing population. Physical activity supports healthy ageing, but motivating exercise is challenging. We aimed to explore staff perceptions towards a virtual reality (VR) omnidirectional treadmill (MOTUS), aimed at increasing physical activity for older adult care home residents. Design Interactive workshops and qualitative evaluation. Settings Eight interactive workshops were held at six care homes and two university sites across Cornwall, England, from September to November 2021. Participants Forty-four staff participated, including care home, supported living, clinical care and compliance managers, carers, activity coordinators, occupational therapists and physiotherapists. Interventions Participants tried the VR treadmill system, followed by focus groups exploring device design, potential usefulness or barriers for care home residents. Focus groups were audio-recorded, transcribed verbatim and thematically analysed. We subsequently conducted a follow-up interview with the technology developer (September 2022) to explore the feedback impact. Results The analysis produced seven key themes: anticipated benefits, acceptability, concerns of use, concerns of negative effects, suitability/unsuitability, improvements and current design. Participants were generally positive towards VR to motivate care home residents’ physical activity and noted several potential benefits (increased exercise, stimulation, social interaction and rehabilitation). Despite the reported potential, staff had safety concerns for frail older residents due to their standing position. Participants suggested design improvements to enhance safety, usability and accessibility. Feedback to the designers resulted in the development of a new seated VR treadmill to address concerns about falls while maintaining motivation to exercise. The follow-up developer interview identified significant value in academia–industry collaboration. Conclusion The use of VR-motivated exercise holds the potential to increase exercise, encourage reminiscence and promote meaningful activity for care home residents. Staff concerns resulted in a redesigned seated treadmill for those too frail to use the standing version. This novel study demonstrates the importance of stakeholder feedback in product design

Negotiated matter: a robotic exploration of craft-driven innovation

This paper introduces a novel approach to craft-driven robotic innovation in architectural research. Here craft is not portrayed as a source of ornamental or historical inspiration, but instead as an open-ended process described by a framework involving material properties, diverging modes of knowledge production and representation, emergent tectonic configurations and embodied interaction with technology. To do so, this paper firstly contrasts a definition of craft (Pye 1968) with practices of robotic architectural production. Additionally, the notion of emergent tectonics resulting from negotiated material and technological processes is addressed by critically situating the theories of architectural tectonics by Kenneth Frampton (2001) and digital tectonics by Leach, Turnbull and Williams (2004) in the context of robotic fabrication in architecture. Finally, the ongoing project “Computing Craft” is presented as a case study illustrating a proposed framework for robotic craft-driven innovation

Multi-ancestry genome-wide association meta-analysis of Parkinson’s disease

\ua9 2023, This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply. Although over 90 independent risk variants have been identified for Parkinson’s disease using genome-wide association studies, most studies have been performed in just one population at a time. Here we performed a large-scale multi-ancestry meta-analysis of Parkinson’s disease with 49,049 cases, 18,785 proxy cases and 2,458,063 controls including individuals of European, East Asian, Latin American and African ancestry. In a meta-analysis, we identified 78 independent genome-wide significant loci, including 12 potentially novel loci (MTF2, PIK3CA, ADD1, SYBU, IRS2, USP8, PIGL, FASN, MYLK2, USP25, EP300 and PPP6R2) and fine-mapped 6 putative causal variants at 6 known PD loci. By combining our results with publicly available eQTL data, we identified 25 putative risk genes in these novel loci whose expression is associated with PD risk. This work lays the groundwork for future efforts aimed at identifying PD loci in non-European populations

Multi-ancestry genome-wide association meta-analysis of Parkinson?s disease

Although over 90 independent risk variants have been identified for Parkinson’s disease using genome-wide association studies, most studies have been performed in just one population at a time. Here we performed a large-scale multi-ancestry meta-analysis of Parkinson’s disease with 49,049 cases, 18,785 proxy cases and 2,458,063 controls including individuals of European, East Asian, Latin American and African ancestry. In a meta-analysis, we identified 78 independent genome-wide significant loci, including 12 potentially novel loci (MTF2, PIK3CA, ADD1, SYBU, IRS2, USP8, PIGL, FASN, MYLK2, USP25, EP300 and PPP6R2) and fine-mapped 6 putative causal variants at 6 known PD loci. By combining our results with publicly available eQTL data, we identified 25 putative risk genes in these novel loci whose expression is associated with PD risk. This work lays the groundwork for future efforts aimed at identifying PD loci in non-European populations

Socio-spatial relationships in design of residential care homes for people living with dementia diagnoses: a grounded theory approach

This paper presents a grounded theory study conceptualising the socio-spatial relationships and lived experiences of residents with a dementia diagnosis in two residential care homes in the United Kingdom. The study challenges generalisations and abstractions of occupants in the design and construction of the built environment, such as through design guides, and prioritises the lived experiences and aspirations of care home residents as rich sources of design knowledge, enabling the articulation of new conceptual and spatial relationships between residents and their physical environment. Mixed qualitative methods were used to build knowledge and construct theory directly from participants in fieldwork, and the constant comparison method was used to systematically derive a grounded theory of the research context. A theory model is constructed that encompasses embodied spatial characteristics, famed as 'liminalities', ‘affordances’ and ‘enablement’, and discrepancies in the representation and realisation of residential care homes, in 'ideologies of spatial conception', and in 'veridictions'. Moreover, the paper illustrates ethical and methodological approaches to architectural research fieldwork in environments with vulnerable people and suggests further research to address co-design methodologies, and ethics in architectural research

Economics of multidisciplinary teams in oncology: a scoping review protocol

OBJECTIVE: The objective of this scoping review is to summarize the current literature on resource use, costs and economic evaluations of multidisciplinary teams in the field of oncology. INTRODUCTION: Multidisciplinary teams are commonly considered best practice and are in widespread use in the field of oncology. However, multidisciplinary teams are expensive to provide, requiring significant clinician time and health care resources. Their effectiveness varies according to the type of cancer and stage of disease, and their cost-effectiveness has not been clearly established. INCLUSION CRITERIA: Papers reporting on the costs of using multidisciplinary teams for the treatment of patients with cancer (at any age, level of care and in any country) will be included in the review. Costs may include the costs or resources used to provide the multidisciplinary teams (e.g. teleconference equipment, travel-time and clinician-time) or subsequent medical or non-medical costs of care. METHODS: Databases, including PubMed, Embase, Cochrane Library, and the NHS Economic Evaluation Database (NHS EED), will be searched from inception. Citations and references of included studies will also be searched. Two reviewers will undertake title and abstract screening, followed by full text screening. Data extraction will be conducted using a customized form. Included studies will be summarized using narrative synthesis structured around intervention characteristics and the type of economic data presented. Additional narrative synthesis will be considered for specific subgroups (depending on numbers and variation).Amanda Reyes Veliz, Jodi Gray, Jonathan Karno