Primary Maxillofacial Large B-Cell Lymphoma in Immunocompetent Patients: Report of 5 Cases

Lymphomas of the oral cavity represent 5% of all lymphomas. They usually occur in immunocompromised patients. Lymphoma arising within a single bone, without visceral or lymph node involvement, is known as primary intraosseous lymphoma. It is a rare condition and constitutes 3.1% of malignant bone tumors and 5% of extranodal lymphomas. Primary lymphoma of the jaw is seldom seen and it is often misdiagnosed. Clinically, the manifestations are usually similar to an odontogenic tumor, cyst, or infection. Radiographically it appears as a radiolucent area that may mimic endodontic lesion, periodontal pathology, or odontogenic cyst or tumor. The initial presentation is commonly followed by multiple unnecessary extractions and/or root canal treatments. We present five cases of rare primary lymphoma of the maxillofacial complex, four of them intraosseous

Brown Tumor as a Result of Hyperparathyroidism in an End-Stage Renal Disease Patient

A 49-year-old male with known history of end-stage renal disease (ESRD) presents with an intraoral exophytic mass of the right mandible. This lesion was given a histologic diagnosis of a Brown tumor. Purpose. To allow physicians to include this lesion in a differential diagnosis when evaluating patients with primary, secondary, or tertiary hyperparathyroidism

Evaluación del estado sanitario de las especies de flora del Jardín Hidrobotánico de Caucasia

Plants are a very valuable natural asset for a territory and its communities, reflecting their importance in population centers, as carbon dioxide sinks, refuge for wildlife species, mitigation of local temperature, as well as cultural and other services. . related to urban sustainability; The role of trees can be affected by their state of conservation, limiting their ecosystem services. Currently, the Caucasia hydrobotanical garden, with an area of ​​approximately 7 hectares, has a high biodiversity richness in flora, both in number of species and families and it is observed that some of the individuals do not have the ideal sanitary conditions for their functioning, so the objective of evaluating the conservation status of the flora species in 4 transects is raised, taking into account the dasometric characteristics of DAP and height, as well as qualitative characteristics of individuals such as (Healthy, acceptably healthy, sick), to indicate the health status taking into account the Murillo (1997) method. Several individuals were found with an acceptably healthy health status, which becomes an opportunity to develop different intervention alternatives that promote the care and conservation of the trees in the botanical garden, giving relevance as a strategic urban ecosystem necessary for the fulfillment of SDG 11. Ensure that cities and human settlements are inclusive, safe, resilient and sustainable, from which the municipality's community can benefit.Las plantas son un  activo natural muy valioso para un territorio y sus comunidades, reflejando su importancia en los centros poblados, como sumideros de dióxido de carbono, refugio para especies de fauna silvestre, mitigación de la temperatura local, así como los servicios culturales y otros relacionados con la sostenibilidad urbana; el papel de los arboles se  puede ver afectados por su estado de conservación, limitando sus servicios ecosistémicos, actualmente el jardín hidrobotánico de Caucasia con una extensión de 7 Ha aproximadamente, cuenta con una alta riqueza biodiversa en flora  tanto en número de especies, como de familias   y se observa que algunos de los individuos no cuentan con las  condiciones sanitarias ideales para su funcionamiento, por lo que se plantea el objetivo de evaluar el estado de conservación de las especies de flora en 4 transectos, teniendo en cuenta las características dasométricas de DAP y altura, así como características cualitativas de los individuos tales como (Sano, aceptablemente sano, enfermo), para indicar el estado sanitario teniendo en cuenta el método de Murillo (1997). Se encontraron varios individuos con estado sanitario aceptablemente sano lo cual se convierte en una oportunidad para desarrollar diferentes alternativas de intervención que  promuevan el cuidado y conservación de los árboles en el jardín botánico, dándole relevancia como ecosistema urbano estratégico  necesario para el cumplimiento del  ODS 11,   Lograr que las ciudades y los asentamientos humanos sean inclusivos, seguros, resilientes y sostenibles, de los cuales pueda beneficiarse la comunidad del municipio

Functional Characterization of Nupr1L, A Novel p53-Regulated Isoform of the High-Mobility Group (HMG)-Related Protumoral Protein Nupr1

We have previously demonstrated a crucial role of nuclear protein 1 (NUPR1) in tumor development and progression. In this work, we report the functional characterization of a novel Nupr1-like isoform (NUPR1L) and its functional interaction with the protumoral factor NUPR1. Through the use of primary sequence analysis, threading, and homology-based molecular modeling, as well as expression and immunolocalization, studies reveal that NUPR1L displays properties, which are similar to member of the HMG-like family of chromatin regulators, including its ability to translocate to the cell nucleus and bind to DNA. Analysis of the NUPR1L promoter showed the presence of two p53-response elements at positions -37 and -7, respectively. Experiments using reporter assays combined with site-directed mutagenesis and using cells with controllable p53 expression demonstrate that both of these sequences are responsible for the regulation of NUPR1L expression by p53. Congruently, NUPR1L gene expression is activated in response to DNA damage induced by oxaliplatin treatment or cell cycle arrest induced by serum starvation, two well-validated methods to achieve p53 activation. Interestingly, expression of NUPR1L downregulates the expression of NUPR1, its closely related protumoral isoform, by a mechanism that involves the inhibition of its promoter activity. At the cellular level, overexpression of NUPR1L induces G1 cell cycle arrest and a decrease in their cell viability, an effect that is mediated, at least in part, by downregulating NUPR1 expression. Combined, these experiments constitute the first functional characterization of NUPR1L as a new p53-induced gene, which negatively regulates the protumoral factor NUPR1.Fil: Lopez, Maria Belen. Centre de Recherche En Cancerologie de Marseille; FranciaFil: Garcia, Maria Noé. Centre de Recherche En Cancerologie de Marseille; FranciaFil: Grasso, Daniel Hector. Centre de Recherche En Cancerologie de Marseille; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Bintz, Jennifer. Centre de Recherche En Cancerologie de Marseille; FranciaFil: Molejon, Maria Ines. Centre de Recherche En Cancerologie de Marseille; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Velez, Gabriel. Mayo Clinic; Estados UnidosFil: Lomberk, Gwen. Mayo Clinic; Estados UnidosFil: Neira, Jose Luis. Universidad de Miguel Hernández; EspañaFil: Urrutia, Raul. Mayo Clinic; Estados UnidosFil: Iovanna, Juan. Centre de Recherche En Cancerologie de Marseille; Franci

Unusual case of a myxoma atrial left presenting with recurrent monoparesis

Usually, embolism is described from cardiac or large artery disease. Atrial fibrillation is the most common cause of cardiogenic emboli in stroke. Myxoma is responsible in only a few cases. We describe here a case of a patient who presented with recurrent pure left brachial monoparesis as a manifestation of a cardiac myxoma

Engaging stakeholders across a socio-environmentally diverse network of water research sites in North and South America

Maintaining and restoring freshwater ecosystem services in the face of local and global change requires adaptive research that effectively engages stakeholders. However, there is a lack of understanding and consensus in the research community regarding where, when, and which stakeholders should be engaged and what kind of researcher should do the engaging (e.g., physical, ecological, or social scientists). This paper explores stakeholder engagement across a developing network of aquatic research sites in North and South America with wide ranging cultural norms, social values, resource management paradigms, and eco-physical conditions. With seven sites in six countries, we found different degrees of engagement were explained by differences in the interests of the stakeholders given the history and perceived urgency of water resource problems as well as differences in the capacities of the site teams to effectively engage given their expertise and resources. We categorized engagement activities and applied Hurlbert and Gupta's split ladder of participation to better understand site differences and distill lessons learned for planning comparative socio-hydrological research and systematic evaluations of the effectiveness of stakeholder engagement approaches. We recommend research networks practice deliberate engagement of stakeholders that adaptively accounts for variations and changes in local socio-hydrologic conditions. This, in turn, requires further efforts to foster the development of well-integrated research teams that attract and retain researchers from multiple social science disciplines and enable training on effective engagement strategies for diverse conditions.Fil: Smyth, Robyn L.. Bard College; Estados UnidosFil: Fatima, Uroosa. Bard College; Estados UnidosFil: Segarra, Monique. Bard College; Estados UnidosFil: Borre, Lisa. Cary Institute of Ecosystem Studies; Estados UnidosFil: Zilio, Mariana Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Económicas y Sociales del Sur. Universidad Nacional del Sur. Departamento de Economía. Instituto de Investigaciones Económicas y Sociales del Sur; ArgentinaFil: Reid, Brian. Universidad Austral de Chile; ChileFil: Pincetl, Stephanie. Institute of the Environment and Sustainability; Estados UnidosFil: Astorga, Anna. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Económicas y Sociales del Sur. Universidad Nacional del Sur. Departamento de Economía. Instituto de Investigaciones Económicas y Sociales del Sur; ArgentinaFil: Huamantinco Cisneros, María Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Geografía y Turismo; ArgentinaFil: Conde, Sergio Daniel. Universidad de la República; UruguayFil: Harmon, Thomas Christopher. University of California Merced; Estados UnidosFil: Hoyos, Natalia. Universidad del Norte; ColombiaFil: Escobar, Jaime. Universidad del Norte; Colombia. Smithsonian Tropical Research Institute; PanamáFil: Lozoya, Juan Pablo. Universidad de la República; UruguayFil: Perillo, Gerardo Miguel E.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto Argentino de Oceanografía. Universidad Nacional del Sur. Instituto Argentino de Oceanografía; Argentina. Universidad Nacional del Sur. Departamento de Geología; ArgentinaFil: Piccolo, Maria Cintia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto Argentino de Oceanografía. Universidad Nacional del Sur. Instituto Argentino de Oceanografía; Argentina. Universidad Nacional del Sur. Departamento de Geografía y Turismo; ArgentinaFil: Rusak, James A.. Dorset Environmental Science Centre; Canadá. Queens University; CanadáFil: Velez, Maria I.. University of Regina; Canad

Estado del arte de los medios de comunicación comunitaria en Bogotá, Cundinamarca y Tolima. Fase final

Imágenes, gráficas, cuadro comparativo, encuesta, entrevistaEl Estado del arte de los medios de comunicación comunitaria en Bogotá, Bogotá-Cundinamarca, Cundinamarca y Tolima se desarrolla en 4 fases, a partir del segundo semestre del año 2006 hasta el segundo semestre del año 2009. Esta última fase tiene entre sus objetivos, analizar los resultados de cada una de estas fases y proponer la creación de una red de medios Comunitarios. La metodología de la investigación adelantada en cada una de las diferentes fases es de orden descriptiva, que permite observar, interactuar y analizar situaciones, costumbres y actitudes a través de mapeo, encuestas, y entrevistas a los representantes y realizadores de los medios comunitarios, y a las audiencias.The State of the art of the mass media community in Bogota, Cundinamarca, and Tolima develops in 4 phases, from the second semester of the year 2006 up to the second semester of the year 2009. the latter phase has between (among) his (her, your) aims (lenses), is to analyze the results of each one of these phases and to propose the creation of a network (net) of community means. . The investigators (researchers) are not tabulators; but they explore and register the information on the base of a hypothesis or theory; they exhibit, summarize and analyze the results found for the construction of the knowledge

COVID-19 Clinical Profile in Latin American Migrants Living in Spain: Does the Geographical Origin Matter?

COVID-19; Latin America; SeverityCOVID-19; Amèrica Llatina; GravetatCOVID-19; América Latina; GravedadThe aim of this study was to describe and compare the clinical characteristics of hospitalized patients with COVID-19 pneumonia according to their geographical origin. This is a retrospective case-control study of hospitalized patients with confirmed COVID-19 pneumonia treated at Vall d’Hebron University Hospital (Barcelona) during the first wave of the pandemic. Cases were defined as patients born in Latin America and controls were randomly selected among Spanish patients matched by age and gender. Demographic and clinical variables were collected, including comorbidities, symptoms, vital signs and analytical parameters, intensive care unit admission and outcome at 28 days after admission. Overall, 1080 hospitalized patients were registered: 774 (71.6%) from Spain, 142 (13.1%) from Latin America and the rest from other countries. Patients from Latin America were considered as cases and 558 Spanish patients were randomly selected as controls. Latin American patients had a higher proportion of anosmia, rhinorrhea and odynophagia, as well as higher mean levels of platelets and lower mean levels of ferritin than Spanish patients. No differences were found in oxygen requirement and mortality at 28 days after admission, but there was a higher proportion of ICU admissions (28.2% vs. 20.2%, p = 0.0310). An increased proportion of ICU admissions were found in patients from Latin America compared with native Spanish patients when adjusted by age and gender, with no significant differences in in-hospital mortality.Isabel Campos-Varela’s research activity is funded by grant PI19/00330 from Instituto de Salud Carlos III. CIBERehd is supported by Instituto de Salud Carlos III. The work was independent of all funding. This research received no specific grant from any funding agency in the public, commercial or not-for-profit sectors

Do ecosystem insecurity and social vulnerability lead to failure of water security?

Achieving water security for humans and ecosystems is a pervasive challenge globally. Extensive areas of the Americas are at significant risk of water insecurity, resulting from global-change processes coupled with regional and local impacts. Drought, flooding, and water quality challenges pose significant threats, while at the same time, rapid urban expansion, competing water demands, river modifications, and expanding global markets for water-intensive agricultural products drive water insecurity. This paper takes a social-ecological systems perspective, aiming to identify examples and pathways towards resilient ecosystems and social development. It draws on lessons from two science-policy network projects, one focusing on water scarcity in arid and semi-arid regions of Argentina, Chile, Brazil, Peru, Mexico and the United States; and the second addressing river and lake basins as sentinels of climate variability and human effects on water quantity and quality in Canada, the United States, Argentina, Colombia, Uruguay and Chile. Together, these ?complementary contrasts? provide an analytical basis to empirically examine stakeholder engagement, knowledge co-production and science-policy interaction supporting decision-making to achieve water security. The paper identifies four tenets for decision-making based on water-security-focused global-change science in the Americas: 1) Decision makers should focus on protecting ecosystems because water security (along with food and energy security) depend on them; 2) Water-use and allocation decisions ought to be made considering future environmental and societal vulnerabilities, especially climate projections; 3) Holistic approaches (at basin or other appropriate levels) are best suited to ensure social-ecological system resilience and reduce vulnerability; and 4) It is essential to support local/traditional livelihoods, and underserved populations to achieve equitable water security and ecosystem resilience.Fil: Scott, Christopher A.. University of Arizona; Estados UnidosFil: Zilio, Mariana Ines. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Harmon, Thomas Christopher. University of California; Estados UnidosFil: Zuniga Teran, Adriana. University of Arizona; Estados UnidosFil: Díaz Caravantes, Rolando. El Colegio de Sonora; MéxicoFil: Hoyos, Natalia. Universidad del Norte; ColombiaFil: Perillo, Gerardo Miguel E.. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Meza, Andrés Francisco. Pontificia Universidad Católica de Chile; ChileFil: Varady, Robert G.. University of Arizona; Estados UnidosFil: Neto, Alfredo Ribeiro. Universidade Federal da Bahia; BrasilFil: Velez, Maria Isabel. University Of Regina; CanadáFil: Martin, Facundo Damian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Ciencias Humanas, Sociales y Ambientales; ArgentinaFil: Escobar, Jaime. Universidad del Norte; ColombiaFil: Piccolo, Maria Cintia. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Mussetta, Paula Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Ciencias Humanas, Sociales y Ambientales; ArgentinaFil: Montenegro, Suzana. Universidade Federal de Pernambuco; BrasilFil: Rusak, James A.. Ontario Ministry Of The Environment; CanadáFil: Pineda, Nicolas. El Colegio de Sonora; Méxic

Evaluation of Two Different Strategies for Schistosomiasis Screening in High-Risk Groups in a Non-Endemic Setting

Diagnosis; Non-endemic; SchistosomiasisDiagnóstico; No endémico; EsquistosomiasisDiagnòstic; No endèmic; EsquistosomiasiA consensus on the recommended screening algorithms for schistosomiasis in asymptomatic high-risk subjects in non-endemic areas is lacking. The objective of this study was to evaluate the real-life performance of direct microscopy and ELISA serology for schistosomiasis screening in a high-risk population in a non-endemic setting. A retrospective cohort study was conducted in two out-patient Tropical Medicine units in Barcelona (Spain) from 2014 to 2017. Asymptomatic adults arriving from the Sub-Saharan region were included. Schistosomiasis screening was conducted according to clinical practice following a different strategy in each setting: (A) feces and urine direct examination plus S. mansoni serology if non-explained eosinophilia was present and (B) S. mansoni serology plus uroparasitological examination as the second step in case of a positive serology. Demographic, clinical and laboratory features were collected. Schistosomiasis cases, clinical management and a 24 month follow-up were recorded for each group. Four-hundred forty individuals were included. The patients were mainly from West African countries. Fifty schistosomiasis cases were detected (11.5% group A vs. 4 % group B, p = 0.733). When both microscopic and serological techniques were performed, discordant results were recorded in 18.4% (16/88). Schistosomiasis cases were younger (p < 0.001) and presented eosinophilia and elevated IgE (p < 0.001) more frequently. Schistosomiasis is a frequent diagnosis among high-risk populations. Serology achieves a similar performance to direct diagnosis for the screening of schistosomiasis in a high-risk population