Caracterización Clínica de Mujeres con Lesiones Precursoras del Cáncer Cervicouterino

Cervical cancer is one of the leading causes of cancer death in women worldwide, it is highly preventable and treatable when detected early. Knowing the clinical and sociodemographic characteristics allows a better understanding of the distribution, prevalence and risk factors of a disease in a given population. The design was quantitative, observational, descriptive, cross-sectional, retrospective and comparative. The sample was 136 women, 68 cases and 68 controls. The mean age was 41 years, 46.3% married and 75% working. They began their sexual life at the age of 19 and on average had 2 sexual partners. The most used contraceptive method was bilateral tubal occlusion in 30.37%. Low-grade squamous intraepithelial lesion was the most frequent at 49.26%. 59.56% reported being asymptomatic. The most used drug was alcohol, with beer being the most frequent drink at 17.7%. Knowledge of population characteristics can guide effective prevention, detection, and treatment strategies to reduce the burden of this potentially preventable and treatable disease.El cáncer cervicouterino es una de las principales causas de muerte por cáncer en mujeres en todo el mundo, es altamente prevenible y tratable cuando es detectado oportunamente. Conocer las características clínicas y sociodemográficas, permite una mayor comprensión de la distribución, prevalencia y factores de riesgo de una enfermedad en una población determinada. El diseño fue cuantitativo, observacional, descriptivo, transversal, retrospectivo y comparativo. La muestra fue de 136 mujeres, 68 casos y 68 controles. La media de edad fue de 41 años, casadas en un 46.3% y 75% trabajadoras. Iniciaron su vida sexual a los 19 años y en promedio tuvieron 2 parejas sexuales. El método anticonceptivo más utilizado fue la oclusión tubaria bilateral en un 30.37%. La lesión intraepitelial escamosa de bajo grado fue la más frecuente en un 49.26%. El 59.56% refirió ser asintomática. La droga más utilizada fue el alcohol siendo la cerveza la bebida más frecuente en un 17.7%. El conocimiento de las características de la población puede guiar a estrategias efectivas de prevención, detección y tratamiento para reducir la carga de esta enfermedad potencialmente prevenible y tratable

Estimación puntual de la relación fecundidad-longitud de graptocorixa abdominalis (hemiptera, corixidae) en el estanque piscícola jorge facio, Estado de México, México

Se analiza de manera puntual la relación fecundidad-longitud de Graptocorixa abdominalis en el estanque piscícola Jorge Facio, Estado de México. Se ubicaron tres estaciones de muestreo en la zona litoral del estanque (A, B y C) y en cada una se midió: temperatura del agua, pH, conductividad, oxígeno disuelto, alcalinidad, dureza y turbiedad. Los insectos fueron capturados con una red de cuchara de 50 X 30 cm de marco y barriendo un área de un metro cuadrado. Se analizaron en total 237 hembras: 65 de la estación A, 60 en la estación B y 112 de la estación C. El mayor número de huevecillos se registró en una hembra de 6.94 mm con 64 y el menor número de huevecillos en una hembra de 6.60 mm con un huevecillo. La mayor relación fecundidad-longitud se presentó en la estación C (F=21.803 L-0.032), seguida de la estación B (F=16.284 L0.1097) y la estación A (F=8.2802 L0.2725). La longitud promedio de G. abdominalis fue 7.65 mm y la fecundidad promedio fue 24.3 huevecillos. Se concluye que los parámetros ambientales registrados en éste periodo de trabajo en cada estación de muestreo no presentaron fluctuaciones notables pero su influencia sobre la fecundidad de G. abdominalis fue considerable

Knowledge and practices regarding toxoplasmosis in housewives: A cross sectional study in a northern Mexican city.

We aimed to determine the knowledge and practices regarding toxoplasmosis among housewives in the northern Mexican city of Durango. One hundred eighty-five women (mean age: 41.27 ± 12.40 years old) with an occupation of housewife were studied. A self-administered questionnaire was used. This tool included items about the parasite Toxoplasma gondii, its transmission routes, general clinical, diagnostic, and treatment aspects of toxoplasmosis, and practices to avoid infection. A minority (<10%) of women knew about the parasite, the disease, how the transmission occurs, the clinical manifestations, how an infection is diagnosed, the treatment, and how to avoid toxoplasmosis. Some women knew that cats can transmit T. gondii infection (20%), and that the parasite can be found in cat feces (20.5%). Only 7.6% of women knew that infection with T. gondii can be transmitted by consumption of contaminated food or water. Only 1.1% of women knew about the prevalence of T. gondii infection. Some (4.9%) women used to taste raw meat while cooking, and 7.6% used to undercook meat. In addition, 20% of women used to eat raw dried meat, and 13.5% consumed untreated water. Less than 90% of women always washed their hands before cooking, and washed fruits or vegetables. The majority (75.1%) of women never wore gloves when handling raw meat. About one quarter (27.6%) of women always froze meat. And 16.2% of women cleaned cat feces. This is the first study regarding knowledge and practices about toxoplasmosis in housewives. Poor knowledge regarding T. gondii infection, toxoplasmosis, and practices to avoid infection among the housewives studied was found. High risk practices for infection were identified. Strategies to improve toxoplasmosis-related knowledge and practices to avoid T. gondii infection and its sequelae in housewives are highly needed

Effect of the COVID-19 pandemic on surgery for indeterminate thyroid nodules (THYCOVID): a retrospective, international, multicentre, cross-sectional study

Background: Since its outbreak in early 2020, the COVID-19 pandemic has diverted resources from non-urgent and elective procedures, leading to diagnosis and treatment delays, with an increased number of neoplasms at advanced stages worldwide. The aims of this study were to quantify the reduction in surgical activity for indeterminate thyroid nodules during the COVID-19 pandemic; and to evaluate whether delays in surgery led to an increased occurrence of aggressive tumours. Methods: In this retrospective, international, cross-sectional study, centres were invited to participate in June 22, 2022; each centre joining the study was asked to provide data from medical records on all surgical thyroidectomies consecutively performed from Jan 1, 2019, to Dec 31, 2021. Patients with indeterminate thyroid nodules were divided into three groups according to when they underwent surgery: from Jan 1, 2019, to Feb 29, 2020 (global prepandemic phase), from March 1, 2020, to May 31, 2021 (pandemic escalation phase), and from June 1 to Dec 31, 2021 (pandemic decrease phase). The main outcomes were, for each phase, the number of surgeries for indeterminate thyroid nodules, and in patients with a postoperative diagnosis of thyroid cancers, the occurrence of tumours larger than 10 mm, extrathyroidal extension, lymph node metastases, vascular invasion, distant metastases, and tumours at high risk of structural disease recurrence. Univariate analysis was used to compare the probability of aggressive thyroid features between the first and third study phases. The study was registered on ClinicalTrials.gov, NCT05178186. Findings: Data from 157 centres (n=49 countries) on 87 467 patients who underwent surgery for benign and malignant thyroid disease were collected, of whom 22 974 patients (18 052 [78·6%] female patients and 4922 [21·4%] male patients) received surgery for indeterminate thyroid nodules. We observed a significant reduction in surgery for indeterminate thyroid nodules during the pandemic escalation phase (median monthly surgeries per centre, 1·4 [IQR 0·6-3·4]) compared with the prepandemic phase (2·0 [0·9-3·7]; p&lt;0·0001) and pandemic decrease phase (2·3 [1·0-5·0]; p&lt;0·0001). Compared with the prepandemic phase, in the pandemic decrease phase we observed an increased occurrence of thyroid tumours larger than 10 mm (2554 [69·0%] of 3704 vs 1515 [71·5%] of 2119; OR 1·1 [95% CI 1·0-1·3]; p=0·042), lymph node metastases (343 [9·3%] vs 264 [12·5%]; OR 1·4 [1·2-1·7]; p=0·0001), and tumours at high risk of structural disease recurrence (203 [5·7%] of 3584 vs 155 [7·7%] of 2006; OR 1·4 [1·1-1·7]; p=0·0039). Interpretation: Our study suggests that the reduction in surgical activity for indeterminate thyroid nodules during the COVID-19 pandemic period could have led to an increased occurrence of aggressive thyroid tumours. However, other compelling hypotheses, including increased selection of patients with aggressive malignancies during this period, should be considered. We suggest that surgery for indeterminate thyroid nodules should no longer be postponed even in future instances of pandemic escalation. Funding: None

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

non present