Application of the MESMA framework. Case study : Strait of Sicily

This deliverable D2.2 comprises a manual containing the protocol for the application of the generic framework to the MESMA case studies. The generic framework (deliverable D2.1) is the central document for the subsequent work packages of MESMA. It provides a best practice guide for monitoring and evaluation of Spatially Managed Areas (SMA) in seven distinctive and clearly outlined steps which comprise 1) setting the context, 2) collation of existing information and mapping, 3) setting of targets, 4) risk analysis and state assessment, 5) assessment of findings against operational objectives, 6) evaluation of the effectiveness of management measures and 7) adaptation of the current management regime based on the outcome of the assessments (for details see D2.1). Although the framework has been developed as a generic tool for use by a range of people involved in evaluating SMAs, the first version of the manual was specifically tailored (in certain areas) for use by the case studies (WP3 of MESMA). It was designed to be an aid to the case studies applying the framework. Thus, feedback on the performance of the framework and manual is guiding the production of a revised framework and manual (D2.3) to be delivered in November 2012. The revised versions will be made available to the wider scientific community and management bodies. This document is the third version of the original document D2.2. As outlined in more detail in D2.1, we have identified several links between the WP2 framework on the one hand and a structured governance analysis (WP6) on the other. These links are indicated in the respective framework steps. The MESMA generic framework and manual does not accommodate for a comprehensivec governance analysis. Therefore the MESMA case study research has two streams – the MESMA framework and the governance research analysis. Governance issues in all MESMA case studies will be analysed through the WP6 Governance Analytical Structure. Further guidance on governance research has been developed and is available in a separate document entitled ‘Guidelines for MESMA WP6 Governance Research’. The WP6 governance research essentially aims to address the following questions: 1) What are the governance approaches and incentives being adopted in a given existing initiative with spatial elements, and how effective are the incentives and governance approaches in that particular context in achieving a particular priority objective? 2) What are the potential incentives and governance approaches that could be implemented to improve effectiveness in achieving the specific objective of an existing initiative and addressing related conflicts? 3) How do wider issues, such as top-down/bottom-up balance, inter-sectoral integration and power, cross-border issues, justice and different levels of knowledge, affect the effectiveness of existing initiatives? This ‘two stream’ approach will provide a clear way forward for combining the MESMA framework and governance research to the case studies in an integrated and coherent manner. As a result, in depth governance analysis covered by the governance work package is outlined briefly in the introduction of each framework step together with specific actions which will be largely carried out under the governance research. Further details on the WP6 governance analysis and on how the two streams of work will be linked from a WP6 governance perspective can be found in the document ‘Guidelines for MESMA WP6 Governance Research’, and Appendix 1 of this document shows a visualisation of the linkages between the two streams of work. It should be noted that in order to be able to link and integrate WP2 and WP6 research, both of the following conditions should be met: 1) Both WP2 and WP6 research are about analysing an existing initiative. Such an initiative may be an integrated marine spatial plan or part of the integrated plan; or if there is no integrated marine spatial plan in place, an existing initiative with spatial elements (e.g. sectoral management plan with spatial restrictions) which may be linked or offer valuable lessons to the future development of an integrated marine spatial plan. 2) WP2 and WP6 research should focus on the same priority objective for at least one run of the WP2 framework. The practical implementation of the framework is also linked to specific tools which will be identified and developed in WP4 and the data handling standards specified in WP5. A revised version of the manual should then interlink the actions underneath each framework step with a set of practical tools comprising technical and conceptual tools.peer-reviewe

Adiponectin accounts for gender differences in hepatocellular carcinoma incidence

Hepatocellular carcinoma (HCC) is the sixth most common cancer type and the fourth leading cause of cancer-related death. This cancer appears with higher incidence in men and during obesity; however, the specific mechanisms underlying this correlation are unknown. Adipose tissue, a key organ in metabolic syndrome, shows evident gender disparities in the production of adipokines. Levels of the important adipokine adiponectin decrease in men during puberty, as well as in the obese state. Here, we show that this decrease in adiponectin levels is responsible for the increased liver cancer risk in males. We found that testosterone activates the protein JNK in mouse and human adipocytes. JNK-mediated inhibition of adiponectin secretion increases liver cancer cell proliferation, since adiponectin protects against liver cancer development through the activation of AMP-activated protein kinase (AMPK) and p38α. This study provides insight into adipose tissue to liver crosstalk and its gender relation during cancer development, having the potential to guide strategies for new cancer therapeutics.G. Sabio is an investigator on the Ramón y Cajal Program. E. Manieri is a La Caixa Foundation fellow. L. Herrera-Melle is a fellow of the Ministerio de Educación, Cultura y Deporte (FPU15-05802). This study was funded by the following grants: G. Sabio was funded by the European Research Council (ERC 260464), European Foundation for the Study of Diabetes–Lilly, Ministerio de Ciencia, Innovación y Universidades (MICINN/SAF2016-79126-R), Comunidad de Madrid (B2017/BMD-3733), and BBVA Becas Leonardo a Investigadores y Creadores Culturales (Investigadores-BBVA-2017; IN[17]_BBM_BAS_0066); M. Marcos was funded by Instituto de Salud Carlos III and Federación Española de Enfermedades Raras (PI16/01548); and J.L. Torres was funded by Junta de Castilla y León GRS (1587/A/17). F.J. Cubero is a Ramón y Cajal Researcher (RYC-2014-15242) and a Gilead Liver Research Scholar 2018, and his work is supported by the Ministerio de Economia y Competitividad Retos (SAF2016-78711), Comunidad de Madrid (S2017/BMD-3727), The Alan Morement Memorial Fund Cholangiocarcinoma Charity (2018/117), the European Cooperation in Science and Technology Action (CA17112), and the European Foundation for Alcohol Research (EA14/18). L. Moran is a Comunidad de Madrid fellow (S2017/BMD-3727). The CNIC is supported by the Ministerio de Ciencia, Innovación y Universidades and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (SEV-2015-0505).S