Fragile Human Capital Causes Poverty in North Bihar: Some Empirical Evidences

Various components of human development of poor households have been studied in North Bihar. The data has revealed that a higher proportion of females are chronically energy deficient than of males in the rural areas. The prevalence of chronic energy deficiency (CED) has been reported in both poor and non-poor households. The incidence of illiteracy and non-enrolment in schools have been found higher in the poor households, whereas the rate of completion of schooling has been observed comparatively high in the non-poor households. The study has further indicated low stake of poor households in the management of rural organizations. The analysis of determinants of poverty has suggested that level of poverty could be reduced through higher investments for the improvement of educational and nutritional status of the rural poor as well as launching of more rural development programmes. The study has observed that targeting of rural poor households in formulating strategies and implementing development programmes warrant special attention. These factors need to be addressed immediately for increasing their capability and skill so that they could be able to get out of poverty sphere. The improvement in social and human development aspects has been the per-requisite for implementation of any programme for poverty attenuation in Bihar.Agricultural and Food Policy,

Discovery of a novel form of Hedgehog that systemically circulates, and its signaling implications in Drosophila.

Hedgehog (Hh) shape up development by playing important role in signaling, and thereby controlling growth and pattern formation. It is for this reason that their spatial distribution is tightly regulated. The 19kDa active form of Hh is modified with a palmitate at its N-terminal and with cholesterol at its C-terminal. This dually lipid modified form of Hh act as a morphogen, and is also referred to as HhNp (Mann and Beachy, 2004). In most cases, they are released from producing cells and spread into adjacent non-expressing cells within the tissue, where it activates target gene expression in a concentration-dependent manner. In Drosophila, Lipophorin (Lpp) particles carry these lipid-modified forms of Hh and play a role in long range signaling in the developing wing disc. Further, these particles circulate throughout the larvae in the hemolymph to distribute nutrients mostly in the form of lipids to different tissues of the animal. Thus, Lpp plays important role in metabolism and development. Hh as a morphogen plays a very important role in development and patterning of embryo and imaginal discs in Drosophila. We wanted to understand the role of Hh in overall development of Drosophila. In my thesis work, I discovered a new form of Hh that is systemically circulating in the 3rd instar larva of Drosophila. I show that imaginal tissues do not produce this form of circulating Hh. Our experiments strongly suggest that systemic Hh can travel from one tissue to another, a feature that was previously unknown. I also show that it could rescue the growth of the imaginal disc, implying its ability to influence cell proliferation. Since the concentration of systemic Hh is low it fails to up regulate the target genes. I characterized fat body as a target of systemically circulating Hh. I clearly demonstrate that fat body transcribes most of the components of Hh signaling pathway except Hh. Further, Hh accumulates in the fat body during late 3rd instar larvae. That makes the fat body an ideal target of systemic Hh. This could shed light in understanding the role of Hh in overall development of Drosophila melanogaster that includes tissue-based interaction

Salinity induced changes in ascorbic acid, hydrogen peroxide, lipid peroxidation and glutathione content in leaves of salt tolerant and salt-susceptible cultivars of cotton (Gossypium hirsutum L.)

The present study was carried out to investigate the effect of NaCl salinization onascorbate content, hydrogen peroxide content and lipid peroxidation in seedlings of saltsensitive(H-1236) and salt-tolerant (H-1226) American cotton genotypes. A nonsignificantchange was observed in ascorbate content in salt-tolerant (H-1226) genotypewhen exposed to salt stress, while there was a significant increase of 33.7% in sensitivegenotype (H-1236). Enhancement in hydrogen peroxide content was observed in both thegenotypes upon NaCl treatment. The basal level of hydrogen peroxide content was higherin sensitive genotype (87.2 μmoles/gFW) as compared to the tolerant genotype (67.9μmoles/gFW). The leaves of both the genotypes showed higher level of malondialdehydecontent when subjected to salt stress, however, the extent of enhancement was more insensitive genotype (182%) as compared to that in tolerant genotype (140%)

Knowledge, attitude and practices regarding reproductive health among rural and urban adolescent girls

Background: Menstruation is a biological event imbued with social, cultural and personal significance. Due to impact of social media and internet the incidence of indulging in unprotected sexual intercourse and unplanned pregnancies are rapidly increasing among teenagers. Objectives were to assess the knowledge regarding safe sex and contraceptive methods and compare the menstrual and sexual awareness among adolescent girls in rural and urban settings.Methods: The health questionnaire was prepared from WHO adolescent health manual as reference base. The adolescent survey was done.Results: In present study maximum number of girls had attained menarche between 12-15 years in both groups. The study showed lack of menstrual hygiene among rural girls in compare to urban girls where 79% girls use either sanitary pads or cotton and in comparison to urban girls, rural girls had more restrictions in going out.Conclusions: Education regarding proper physiology of menses and there should be open discussion regarding restrictions and taboos related to menses at the school level to minimise the false beliefs

A psychophysiological investigation of laterality in human emotion elicited by pleasant and unpleasant film clips

<p>Abstract</p> <p>Background</p> <p>Research on laterality in emotion suggests a dichotomy between the brain hemispheres. The present study aimed to investigate this further using a modulated startle reflex paradigm.</p> <p>Methods</p> <p>We examined the effects of left and the right ear stimulation on the modulated startle reflex (as indexed by eyeblink magnitude, measured from the right eye) employing short (2 min) film clips to elicit emotions in 16 right-handed healthy participants. The experiment consisted of two consecutive sessions on a single occasion. The acoustic startle probes were presented monaurally to one of the ears in each session, counterbalanced across order, during the viewing of film clips.</p> <p>Results</p> <p>The findings showed that eyeblink amplitude in relation to acoustic startle probes varied linearly, as expected, from pleasant through neutral to unpleasant film clips, but there was no interaction between monaural probe side and foreground valence.</p> <p>Conclusions</p> <p>Our data indicate the involvement of both hemispheres when affective states, and associated startle modulations, are produced, using materials with both audio and visual properties. From a methodological viewpoint, the robustness of film clip material including audio properties might compensate for the insufficient information reaching the ipsilateral hemisphere when using static pictures. From a theoretical viewpoint, a right ear advantage for verbal processing may account for the failure to detect the expected hemispheric difference. The verbal component of the clips would have activated the left hemisphere, possibly resulting in an increased role for the left hemisphere in both positive and negative affect generation.</p

The sterol-binding antibiotic nystatin inhibits entry of non-opsonized Leishmania donovani into macrophages

Leishmania donovani is an obligate intracellular parasite that infects macrophages of the vertebrate host resulting in visceral leishmaniasis in humans, a major public health problem worldwide. The molecular mechanisms involved in internalization of Leishmania are still poorly characterized. We report here that cholesterol sequestration by the sterol-binding antifungal polyene antibiotic nystatin markedly inhibits binding and entry of non-opsonized L. donovani promastigotes into macrophages. Interestingly, these effects are not observed when serum-opsonized L. donovani are used for infectivity studies thus pointing the essential role of cholesterol in mediating entry of the parasite via the non-opsonic pathway. Based on our earlier results where leishmanial infectivity was shown to be sensitive to physical depletion of cholesterol from macrophages, these results indicate that the mere sequestration of cholesterol in the host plasma membrane is sufficient to inhibit the binding and entry of non-opsonized L. donovani. These results represent the first report on the effect of a cholesterol-sequestering agent on the entry of Leishmania parasites to host macrophages. More importantly, these findings offer the possibility of reevaluating the mechanism behind the effectiveness of current therapeutic strategies to treat leishmaniasis