3,239 research outputs found

    The Attract trial: A step forward for evidence based DVT care

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    Science with the ngVLA: Extreme Scattering Events and Symmetric Achromatic Variations

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    Radio variability in quasars has been seen on timescales ranging from days to years due to both intrinsic and propagation induced effects. Although separating the two is not always straight-forward, observations of singular `events' in radio light curves have led to two compelling, and thus far unresolved mysteries in propagation induced variability--- extreme scattering events (ESE) that are a result of plasma lensing by AU-scale ionized structures in the interstellar medium, and symmetric achromatic variability (SAV) that is likely caused by gravitational lensing by 103M\gtrsim 10^3\,M_\odot objects. Nearly all theoretical explanations describing these putative lenses have remarkable astrophysical implications. In this chapter we introduce these phenomena, state the unanswered questions and discuss avenues to answer them with a \sim weekly-cadence flux-monitoring survey of 10310410^3-10^4 flat-spectrum radio quasars with the ngVLA.Comment: To be published in the ASP Monograph Series, "Science with a Next-Generation VLA", ed. E. J. Murphy (ASP, San Francisco, CA

    La Freccia Rossa: An IR-dark cloud hosting the Milky Way intermediate-mass black hole candidate

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    The dynamics of the high-velocity compact molecular cloud CO-0.40-0.22 have been interpreted as evidence for a 105M\sim10^{5}M_{\odot} black hole within 60 pc of Sgr A*. Recently, Oka et al. have identified a compact millimetre-continuum source, CO-0.40-0.22*, with this candidate black hole. Here we present a collation of radio and infrared data at this location. ATCA constraints on the radio spectrum, and the detection of a mid-infrared counterpart, are in tension with an Sgr A*-like model for CO-0.40-0.22* despite the comparable bolometric to Eddington luminosity ratios under the IMBH interpretation. A protostellar-disk scenario is, however, tenable. CO-0.40-0.22(*) is associated with an arrowhead-shaped infrared-dark cloud (which we call the Freccia Rossa). Radio-continuum observations reveal a candidate HII region associated with the system. If the VLSR70V_{\rm LSR}\approx70 km s1^{-1} systemic velocity of CO-0.40-0.22 is common to the entire Freccia Rossa system, we hypothesise that it is the remnant of a high-velocity cloud that has plunged into the Milky Way from the Galactic halo.Comment: 6 pages, 3 figures, submitted to MNRAS Letter

    Slow inactivation does not affect movement of the fast inactivation gate in voltage-gated Na+ channels.

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    Voltage-gated Na+ channels exhibit two forms of inactivation, one form (fast inactivation) takes effect on the order of milliseconds and the other (slow inactivation) on the order of seconds to minutes. While previous studies have suggested that fast and slow inactivation are structurally independent gating processes, little is known about the relationship between the two. In this study, we probed this relationship by examining the effects of slow inactivation on a conformational marker for fast inactivation, the accessibility of a site on the Na+ channel III-IV linker that is believed to form a part of the fast inactivation particle. When cysteine was substituted for phenylalanine at position 1304 in the rat skeletal muscle sodium channel (microl), application of [2-(trimethylammonium)ethyl]methanethiosulfonate (MTS-ET) to the cytoplasmic face of inside-out patches from Xenopus oocytes injected with F1304C RNA dramatically disrupted fast inactivation and displayed voltage-dependent reaction kinetics that closely paralleled the steady state availability (hinfinity) curve. Based on this observation, the accessibility of cys1304 was used as a conformational marker to probe the position of the fast inactivation gate during the development of and the recovery from slow inactivation. We found that burial of cys1304 is not altered by the onset of slow inactivation, and that recovery of accessibility of cys1304 is not slowed after long (2-10 s) depolarizations. These results suggest that (a) fast and slow inactivation are structurally distinct processes that are not tightly coupled, (b) fast and slow inactivation are not mutually exclusive processes (i.e., sodium channels may be fast- and slow-inactivated simultaneously), and (c) after long depolarizations, recovery from fast inactivation precedes recovery from slow inactivation

    All-sky signals from recombination to reionization with the SKA

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    Cosmic evolution in the hydrogen content of the Universe through recombination and up to the end of reionization is expected to be revealed as subtle spectral features in the uniform extragalactic cosmic radio background. The redshift evolution in the excitation temperature of the 21-cm spin flip transition of neutral hydrogen appears as redshifted emission and absorption against the cosmic microwave background. The precise signature of the spectral trace from cosmic dawn and the epoch of reionization are dependent on the spectral radiance, abundance and distribution of the first bound systems of stars and early galaxies, which govern the evolution in the spin-flip level populations. Redshifted 21 cm from these epochs when the spin temperature deviates from the temperature of the ambient relic cosmic microwave background results in an all-sky spectral structure in the 40-200 MHz range, almost wholly within the band of SKA-Low. Another spectral structure from gas evolution is redshifted recombination lines from epoch of recombination of hydrogen and helium; the weak all-sky spectral structure arising from this event is best detected at the upper end of the 350-3050 MHz band of SKA-mid. Total power spectra of SKA interferometer elements form the measurement set for these faint signals from recombination and reionization; the inter-element interferometer visibilities form a calibration set. The challenge is in precision polarimetric calibration of the element spectral response and solving for additives and unwanted confusing leakages of sky angular structure modes into spectral modes. Herein we discuss observing methods and design requirements that make possible these all-sky SKA measurements of the cosmic evolution of hydrogen.Comment: Accepted for publication in the SKA Science Book 'Advancing Astrophysics with the Square Kilometre Array', to appear in 201

    Making an impact: The influence of policies to reduce emissions from aviation on the business travel patterns of individual corporations

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    The contribution of aviation to global carbon dioxide (CO2) emissions is projected to triple by 2050. As nations strive to meet CO2 reduction targets, policy interventions to manage the growth of emissions arising from air travel are likely. Here, we investigate the potential influence of aviation emissions reduction policies on the business travel patterns of individual corporations. Using travel data from six UK-based companies, we find that increased ticket prices can deliver substantial emissions cuts, particularly on premium class flights, and may provide strong financial incentives to seek modal and/or technological alternatives to flying. We also find that corporations from different business sectors vary in their responsiveness to arange of policy options. Finally, we examine questionnaire data to determine whether companies more broadly are going beyond compliance to mitigate their environmental impact by managing travel-related emissions voluntarily. Although many corporations are measuring and reporting emissions, only a limited number are willing to implement in-house reduction policies prior to regulation

    Pharmacomechanical therapy for deep-vein thrombosis

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    Upper Limits on the 21 cm Epoch of Reionization Power Spectrum from One Night with LOFAR

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    We present the first limits on the Epoch of Reionization 21 cm H I power spectra, in the redshift range z = 7.9–10.6, using the Low-Frequency Array (LOFAR) High-Band Antenna (HBA). In total, 13.0 hr of data were used from observations centered on the North Celestial Pole. After subtraction of the sky model and the noise bias, we detect a non-zero Δ^2_I = (56 ± 13 mK)^2 (1-σ) excess variance and a best 2-σ upper limit of Δ^2_(21) < (79.6 mK)^2 at k = 0.053 h cMpc^(−1) in the range z = 9.6–10.6. The excess variance decreases when optimizing the smoothness of the direction- and frequency-dependent gain calibration, and with increasing the completeness of the sky model. It is likely caused by (i) residual side-lobe noise on calibration baselines, (ii) leverage due to nonlinear effects, (iii) noise and ionosphere-induced gain errors, or a combination thereof. Further analyses of the excess variance will be discussed in forthcoming publications
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