The information content of gravitational wave harmonics in compact binary inspiral

The nonlinear aspect of gravitational wave generation that produces power at harmonics of the orbital frequency, above the fundamental quadrupole frequency, is examined to see what information about the source is contained in these higher harmonics. We use an order (4/2) post-Newtonian expansion of the gravitational wave waveform of a binary system to model the signal seen in a spaceborne gravitational wave detector such as the proposed LISA detector. Covariance studies are then performed to determine the ultimate accuracy to be expected when the parameters of the source are fit to the received signal. We find three areas where the higher harmonics contribute crucial information that breaks degeneracies in the model and allows otherwise badly-correlated parameters to be separated and determined. First, we find that the position of a coalescing massive black hole binary in an ecliptic plane detector, such as OMEGA, is well-determined with the help of these harmonics. Second, we find that the individual masses of the stars in a chirping neutron star binary can be separated because of the mass dependence of the harmonic contributions to the wave. Finally, we note that supermassive black hole binaries, whose frequencies are too low to be seen in the detector sensitivity window for long, may still have their masses, distances, and positions determined since the information content of the higher harmonics compensates for the information lost when the orbit-induced modulation of the signal does not last long enough to be apparent in the data.Comment: 13 pages, 5 figure

LISA Response Function and Parameter Estimation

We investigate the response function of LISA and consider the adequacy of its commonly used approximation in the high-frequency range of the observational band. We concentrate on monochromatic binary systems, such as white dwarf binaries. We find that above a few mHz the approxmation starts becoming increasingly inaccurate. The transfer function introduces additional amplitude and phase modulations in the measured signal that influence parameter estmation and, if not properly accounted for, lead to losses of signal-to-noise ratio.Comment: 4 pages, 2 figures, amaldi 5 conference proceeding

Classification of human actions into dynamics based primitives with application to drawing tasks

We develop the study of primitives of human motion, which we refer to as movemes. The idea is to understand human motion by decomposing it into a sequence of elementary building blocks that belong to a known alphabet of dynamical systems. How can we construct an alphabet of movemes from human data? In this paper we address this issue by introducing the notion of well-posednes. Using examples from human drawing data, we show that the well-posedness notion can be applied in practice so to establish if sets of actions, viewed as signals in time, can define movemes

Studying stellar binary systems with the Laser Interferometer Space Antenna using Delayed Rejection Markov chain Monte Carlo methods

Bayesian analysis of LISA data sets based on Markov chain Monte Carlo methods has been shown to be a challenging problem, in part due to the complicated structure of the likelihood function consisting of several isolated local maxima that dramatically reduces the efficiency of the sampling techniques. Here we introduce a new fully Markovian algorithm, a Delayed Rejection Metropolis-Hastings Markov chain Monte Carlo method, to efficiently explore these kind of structures and we demonstrate its performance on selected LISA data sets containing a known number of stellar-mass binary signals embedded in Gaussian stationary noise.Comment: 12 pages, 4 figures, accepted in CQG (GWDAW-13 proceedings

Flow cytometry analysis of acute promyelocytic leukemia: the power of 'surface hematology'

n/

Optical properties of V2O3 in its whole phase diagram

Vanadium sesquioxide V2O3 is considered a textbook example of Mott-Hubbard physics. In this paper we present an extended optical study of its whole temperature/doping phase diagram as obtained by doping the pure material with M=Cr or Ti atoms (V1-xMx)2O3. We reveal that its thermodynamically stable metallic and insulating phases, although macroscopically equivalent, show very different low-energy electrodynamics. The Cr and Ti doping drastically change both the antiferromagnetic gap and the paramagnetic metallic properties. A slight chromium content induces a mesoscopic electronic phase separation, while the pure compound is characterized by short-lived quasiparticles at high temperature. This study thus provides a new comprehensive scenario of the Mott-Hubbard physics in the prototype compound V2O3

Disruption of Claudin-Made Tight Junction Barriers by Clostridium perfringens Enterotoxin: Insights from Structural Biology

Claudins are a family of integral membrane proteins that enable epithelial cell/cell interactions by localizing to and driving the formation of tight junctions. Via claudin self-assembly within the membranes of adjoining cells, their extracellular domains interact, forming barriers to the paracellular transport of small molecules and ions. The bacterium Clostridium perfringens causes prevalent gastrointestinal disorders in mammals by employing an enterotoxin (CpE) that targets claudins. CpE binds to claudins at or near tight junctions in the gut and disrupts their barrier function, potentially by disabling their assembly or via cell signaling means—the mechanism(s) remain unclear. CpE ultimately destroys claudin-expressing cells through the formation of a cytotoxic membrane-penetrating β-barrel pore. Structures obtained by X-ray crystallography of CpE, claudins, and claudins in complex with CpE fragments have provided the structural bases of claudin and CpE functions, revealing potential mechanisms for the CpE-mediated disruption of claudin-made tight junctions. This review highlights current progress in this space—what has been discovered and what remains unknown—toward efforts to elucidate the molecular mechanism of CpE disruption of tight junction barriers. It further underscores the key insights obtained through structure that are being applied to develop CpE-based therapeutics that combat claudin-overexpressing cancers or modulate tight junction barriers

Fall detection using a head-worn barometer

Falls are a significant health and social problem for older adults and their relatives. In this paper we study the use of a barometer placed at the user’s head (e.g., embedded in a pair of glasses) as a means to improve current wearable sensor-based fall detection methods. This approach proves useful to reliably detect falls even if the acceleration produced during the impact is relatively small. Prompt detection of a fall and/or an abnormal lying condition is key to minimize the negative effect on health