Coal desulfurization

A method for enhancing solubilizing mass transport of reactive agents into and out of carbonaceous materials, such as coal. Solubility parameters of mass transfer and solvent media are matched to individual peaks in the solubility parameter spectrum of coals to enhance swelling and/or dissolution. Methanol containing reactive agent carriers are found particularly effective for removing organic sulfur from coals by chlorinolysis

Receiver-Side TCP Countermeasure in Cellular Networks.

Cellular-based networks keep large buffers at base stations to smooth out the bursty data traffic, which has a negative impact on the user's Quality of Experience (QoE). With the boom of smart vehicles and phones, this has drawn growing attention. For this paper, we first conducted experiments to reveal the large delays, thus long flow completion time (FCT), caused by the large buffer in the cellular networks. Then, a receiver-side transmission control protocol (TCP) countermeasure named Delay-based Flow Control algorithm with Service Differentiation (DFCSD) was proposed to target interactive applications requiring high throughput and low delay in cellular networks by limiting the standing queue size and decreasing the amount of packets that are dropped in the eNodeB in Long Term Evolution (LTE). DFCSD stems from delay-based congestion control algorithms but works at the receiver side to avoid the performance degradation of the delay-based algorithms when competing with loss-based mechanisms. In addition, it is derived based on the TCP fluid model to maximize the network utility. Furthermore, DFCSD also takes service differentiation into consideration based on the size of competing flows to shorten their completion time, thus improving user QoE. Simulation results confirmed that DFCSD is compatible with existing TCP algorithms, significantly reduces the latency of TCP flows, and increases network throughput

An artificial intelligence driven multi-feature extraction scheme for big data detection

© 2019 IEEE. The Internet improves the speed of information dissemination, and the scale of unstructured text data is expanding and increasingly being used for mass communication. Although these large amounts of data meet the infinite demand, it is difficult to find public focus in a timely manner. Therefore, information extraction from big data has become an important research issue, and there are many published studies on big data processing at home and abroad. In this paper, we propose a multi-feature keyword extraction method, and based on this, an artificial intelligence driven big data MFE scheme is designed, then an application example of the general scheme is expanded and detailed. Taking news as the carrier, this scheme is applied to the algorithm design of hot event detection. As a result, a multi-feature fusion clustering algorithm is proposed based on user attention with two main stages. In the first stage, a multi-feature fusion model is developed to evaluate keywords, and this model combines the term frequency and part of speech features. We use it to extract keywords for representing news and events. In the second stage, we perform clustering and detect hot events in accordance with the procedure, and during the composition of news clusters, we analyze several variadic parameters in order to explore the optimal effectiveness. Then, experiments on the news corpus are conducted, and the results show that the approach presented herein performs well

On the implications of aerosol liquid water and phase separation for modeled organic aerosol mass

Water is an important component of PM2.5 Many traditional SOA species are highly soluble and thus can be considered extractable Water can influence the partitioning of compounds traditionally considered insoluble in models Organic aerosol takes up water according to RH Organic aerosol interacts with inorganic water Deviations in ideality (solubility) must be considered

Transcriptional networks in plasmacytoid dendritic cells stimulated with synthetic TLR 7 agonists

<p>Abstract</p> <p>Background</p> <p>Plasmacytoid Dendritic Cells (pDC) comprise approximately 0.2 to 0.8% of the blood mononuclear cells and are the primary type 1 interferon (IFN), producing cells, secreting high levels of IFN in response to viral infections. Plasmacytoid dendritic cells express predominantly TLRs 7 & 9, making them responsive to ssRNA and CpG DNA. The objective of this study was to evaluate the molecular and cellular processes altered upon stimulation of pDC with synthetic TLR 7 and TLR 7/8 agonists. To this end, we evaluated changes in global gene expression upon stimulation of 99.9% pure human pDC with the TLR7 selective agonists 3M-852A, and the TLR7/8 agonist 3M-011.</p> <p>Results</p> <p>Global gene expression was evaluated using the Affymetrix U133A GeneChip^®and selected genes were confirmed using real time TaqMan^®RTPCR. The gene expression profiles of the two agonists were similar indicating that changes in gene expression were solely due to stimulation through TLR7. Type 1 interferons were among the highest induced genes and included IFNB and multiple IFNα subtypes, IFNα2, α5, α6, α8, α1/13, α10, α14, α16, α17, α21. A large number of chemokines and co-stimulatory molecules as well as the chemokine receptor CCR7 were increased in expression indicating maturation and change in the migratory ability of pDC. Induction of an antiviral state was shown by the expression of several IFN-inducible genes with known anti-viral activity. Further analysis of the data using the pathway analysis tool MetaCore gave insight into molecular and cellular processes impacted. The analysis revealed transcription networks that show increased expression of signaling components in TLR7 and TLR3 pathways, and the cytosolic anti-viral pathway regulated by RIG1 and MDA5, suggestive of optimization of an antiviral state targeted towards RNA viruses. The analysis also revealed increased expression of a network of genes important for protein ISGylation as well as an anti-apoptotic and pro-survival gene expression program.</p> <p>Conclusion</p> <p>Thus this study demonstrates that as early as 4 hr post stimulation, synthetic TLR7 agonists induce a complex transcription network responsible for activating pDC for innate anti-viral immune responses with optimized responses towards RNA viruses, increased co-stimulatory capacity, and increased survival.</p

Comparison of human B cell activation by TLR7 and TLR9 agonists

Research articl

Performance Evaluation of Multipath TCP Scheduling Algorithms

© 2013 IEEE. One of the goals of 5G is to provide enhanced mobile broadband and enable low latency in some use cases. To achieve this aim, the Internet Engineering Task Force has proposed the Multipath TCP by utilizing the feature of dual connectivity in 5G, where a 5G device can be served by two different base stations. However, the path heterogeneity between the 5G device and the server may cause a packet out-of-order problem. The researchers proposed a number of scheduling algorithms to tackle this issue. This paper introduces the existing algorithms, with the aim to make a thorough comparison between the existing scheduling algorithms and provide the guidelines for designing new scheduling algorithms in 5G, we have conducted an extensive set of emulation studies based on the real Linux experimental platform. The evaluation covers a wide range of network scenarios to investigate the impact of different network metrics, namely, RTT, buffer size, and file size on the performance of existing widely deployed scheduling algorithms

Combined TLR and CD40 Triggering Induces Potent CD8+ T Cell Expansion with Variable Dependence on Type I IFN

Toll-like receptors are important in the activation of innate immunity, and CD40 is a molecule critical for many T and B cell responses. Whereas agonists for either pathway have been used as vaccine adjuvants, we show that a combination of Toll-like receptor (TLR)7 and CD40 agonists synergize to stimulate CD8+ T cell responses 10–20-fold greater than the use of either agonist alone. Antigen-specific CD8+ T cells elicited from combination CD40/TLR7 treatment demonstrated both lytic activities and interferon (IFN)γ production and an enhanced secondary response to antigenic challenge. Agonists for TLRs 2/6, 3, 4, and 9 also synergized with CD40 stimulation, demonstrating that synergy with the CD40 pathway is a property of TLR-derived stimuli in general. The CD8+ T cell expansion induced by CD40/TLR7 triggering was independent of CD4+ T cells, IFNγ, and IL-12 but dependent on B7-mediated costimulation and surprisingly on type I IFN. These studies provide the rational basis for the use of TLR and CD40 agonists together as essential adjuvants to optimize vaccines designed to elicit protective or therapeutic immunity