49 research outputs found
Naturbilder in der Lyrik von Heinrich Heine und Juhan Liiv
Das Thema meiner literaturwissenschaftlichen Forschung ist ein Vergleich der lyrischen
Dichtung von Heinrich Heine (1797β1856), einem der bekanntesten deutschen Dichter
und Schriftsteller, der heutzutage als letzter Vertreter und gleichzeitig als Γberwinder
der Romantik gilt, und von Juhan Liiv (1864β1913), dem estnischen Dichter, der am
Ende des 19. Jahrhunderts lebte und fΓΌr seine Experimente mit der Poetik und Lyrik
bekannt ist. WΓ€hrend die Bedeutung der Lyrik von Heinrich Heine in der Weltliteratur
schon lΓ€ngst gesichert ist, wird die von Juhan Liiv erst entdeckt.https://www.ester.ee/record=b5458893*es
ΠΠΎΠ΄ΠΈΡΠΈΠΊΠ°ΡΠΈΡ ΡΠΈΠ·ΠΈΠΊΠΎ-Ρ ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΡ ΡΠ²ΠΎΠΉΡΡΠ² Π±ΠΈΠΎΡΠΎΠ²ΠΌΠ΅ΡΡΠΈΠΌΡΡ ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠΎΠ² ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΈΠΎΠ½Π½ΠΎΠΉ ΠΈΠΌΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΈ
Π Π΄Π°Π½Π½ΠΎΠΉ ΡΠ°Π±ΠΎΡΠ΅ Π±ΡΠ»ΠΎ ΡΠ°ΡΡΠΌΠΎΡΡΠ΅Π½ΠΎ Π²Π»ΠΈΡΠ½ΠΈΠ΅ ΠΈΠΎΠ½Π½ΠΎΠΉ ΠΈΠΌΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΈ ΠΈΠΎΠ½ΠΎΠ² ΡΠ΅ΡΠ΅Π±ΡΠ°, ΡΠΈΠ½ΠΊΠ° ΠΈ ΠΌΠ°Π³Π½ΠΈΡ Ρ ΡΠΊΡΠΏΠΎΠ·ΠΈΡΠΈΠΎΠ½Π½ΡΠΌΠΈ Π΄ΠΎΠ·Π°ΠΌΠΈ 110β^ ΠΈ ΠΈΠΎΠ½/ΡΠΌ^ Π½Π° ΠΏΠΎΠ²Π΅ΡΡ
Π½ΠΎΡΡΠ½ΡΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π° ΠΏΠΎΠ»ΠΈΠ²ΠΈΠ½ΠΈΠ»ΠΎΠ²ΠΎΠ³
Surface property modification of biodegradable polymer and composites by low-temperature atmospheric plasma treatment
Effect of silver ion implantation on surface physicochemical properties of composite materials based on polylactic acid and hydroxyapatite
The investigation of surface physicochemical and biological properties of polylactic acid and hydroxyapatite and composite materials based on them modified by Ag 1Γ1015 ion/cm2 and 1Γ1016 ion/cm2 40 keV ion implantation is presented. X-ray analysis reveals that ion implantation of the above mentioned materials leads to crystallite size and degree of crystallinity increase. The intensity of -Π‘=Π line is found by IR-spectroscopy to be decreased that is associated with surface layer carbonization processes of PLA during ion implantation. Silver ion introducing is established to enhance hydrophobic properties of the materials; this process is accompanied by free surface energy decreasing. It is shown that cell viability of non-implanted PLA is comparable with a control sample and ion implantation negatively affects to cell viability. The investigated materials can be promising for biomedical application
Regularities of PLA mechanical property modification under ion implantation conditions
The investigations of the surface physicochemical properties of polylactic acid (PLA) modified by argon, carbon and silver ion implantation to fluences of 1β1014, 1β1015 and 1β1016 cm2 and energies of 20 keV, 20 keV and 42 keV respectively are described. The projected ion ranges in the polymer matrix are estimated by the computer simulation with the TRIDYN code, as well as energies of electron and nuclear stopping are assessed according to the SRIM modelling. The microhardness and elastic modulus are established to be dependent on the degree of crystallinity of the material. It was found that the microdistortions and strains of the PLA crystal lattice increase after ion implantation due to the structural alteration and defect formation. Long-range effect expressed as bigger depth of modified surface layer than the ion range in the material is suggested as a result of the radiation- stimulated diffusion and thermal restructuring of the material
Low-temperature barrier discharge plasma modification of scaffolds based on polylactic acid
We have explored the effect of low-temperature barrier discharge plasma treatment in oxygen, nitrogen, and argon on modification of the physicochemical properties of polylactic acid (PLA)-based scaffolds. The cellular-mediated immune response to the interaction of macrophages of three donors with the modified surface of PLA-based scaffolds was also nvestigated. Carbonization of the PLA surface accompanied by a carbon atomic concentration increase is shown to occur following plasma treatment. Argon plasma significantly affects the wettability characteristics of PLA; the hydrophilicity and lipophilicity are improved, and the surface energy is increased. The viability of cells in the presence of plasma-modified PLA scaffolds is lower than that for unmodified PLA but remains greater than that for the negative control. We find that PLA scaffolds do not cause increased expression of the proinflammatory (TNFΞ±, IL-6, IL-1Ξ²) cytokines after 6 days of cell cultivation. At the same time, PLA scaffolds do not affect the increased production of anti-inflammatory cytokines (IL-10)
ΠΡΠΎΡΠ΅ΡΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΠ΅ ΠΈ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°ΡΠ΅Π»ΡΠ½ΡΠ΅ ΡΡΡΠ°ΡΠ΅Π³ΠΈΠΈ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ Π°Π±ΠΈΡΡΡΠΈΠ΅Π½ΡΠΎΠ²
The article deals with approaches to the understanding of the profession and professional choice in domestic and foreign scientific thought. The key issues of the study of vocational guidance and professional choice are presented in the historical perspective. The interrelation of choosing future life path, professional future and that educational institution, which in the future will allow youth not only to get a profession, but also serves as a launching pad for future career, is considered particularly acute by the end of school before each graduate. Today, the choice of the educational institution by the applicants remains a significant problem for them and in this regard the researchers face the task of characterizing the educational behavior of modern high school students, future applicants.To answer these questions, the staff of Faculty of sociology of the Lomonosov Moscow State University was conducted among senior pupil of Moscow schools. The article presents the results of studies of different years of satisfaction with the level of received education, the motives for choosing the future education of senior pupils, and value orientations of youth. The main factors influencing the choice of the desired level of education and educational institution, as well as the basic model-goals of education used by youth in choosing their life path, were highlighted. The significance of higher education for future applicants and a steady increase in the trend of the spread of consumer behavior of youth, orientation in their life strategies towards success and high material wealth, a certain social status, are confirmed on the basis of the obtained data.Π ΡΡΠ°ΡΡΠ΅ ΡΠ°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°ΡΡΡΡ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄Ρ ΠΊ ΠΏΠΎΠ½ΠΈΠΌΠ°Π½ΠΈΡ ΠΏΡΠΎΡΠ΅ΡΡΠΈΠΈ ΠΈ ΠΏΡΠΎΡΠ΅ΡΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ Π²ΡΠ±ΠΎΡΠ° Π² ΠΎΡΠ΅ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠΉ ΠΈ Π·Π°ΡΡΠ±Π΅ΠΆΠ½ΠΎΠΉ Π½Π°ΡΡΠ½ΠΎΠΉ ΠΌΡΡΠ»ΠΈ. ΠΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Ρ Π² ΠΈΡΡΠΎΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ΅ΡΡΠΎΡΠΏΠ΅ΠΊΡΠΈΠ²Π΅ ΠΊΠ»ΡΡΠ΅Π²ΡΠ΅ Π²ΠΎΠΏΡΠΎΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΡΠΎΡΠ΅ΡΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠΉ ΠΎΡΠΈΠ΅Π½ΡΠ°ΡΠΈΠΈ ΠΈ ΠΏΡΠΎΡΠ΅ΡΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ Π²ΡΠ±ΠΎΡΠ°. Π Π°ΡΡΠΌΠΎΡΡΠ΅Π½Π° Π²Π·Π°ΠΈΠΌΠΎΡΠ²ΡΠ·Ρ Π²ΡΠ±ΠΎΡΠ° ΡΠ²ΠΎΠ΅Π³ΠΎ Π΄Π°Π»ΡΠ½Π΅ΠΉΡΠ΅Π³ΠΎ ΠΆΠΈΠ·Π½Π΅Π½Π½ΠΎΠ³ΠΎ ΠΏΡΡΠΈ, ΡΠ²ΠΎΠ΅Π³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ Π±ΡΠ΄ΡΡΠ΅Π³ΠΎ ΠΈ ΡΠΎΠ³ΠΎ ΡΡΠ΅Π±Π½ΠΎΠ³ΠΎ Π·Π°Π²Π΅Π΄Π΅Π½ΠΈΡ, ΠΊΠΎΡΠΎΡΠΎΠ΅ Π² Π΄Π°Π»ΡΠ½Π΅ΠΉΡΠ΅ΠΌ ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΡ Π½Π΅ ΡΠΎΠ»ΡΠΊΠΎ ΠΏΠΎΠ»ΡΡΠΈΡΡ ΠΏΡΠΎΡΠ΅ΡΡΠΈΡ, Π½ΠΎ ΠΈ ΠΏΠΎΡΠ»ΡΠΆΠΈΡ ΡΡΠ°ΡΡΠΎΠ²ΠΎΠΉ ΠΏΠ»ΠΎΡΠ°Π΄ΠΊΠΎΠΉ Π΄Π»Ρ Π±ΡΠ΄ΡΡΠ΅ΠΉ ΠΊΠ°ΡΡΠ΅ΡΡ. Π‘Π΅Π³ΠΎΠ΄Π½Ρ Π²ΡΠ±ΠΎΡ ΡΡΠ΅Π±Π½ΠΎΠ³ΠΎ Π·Π°Π²Π΅Π΄Π΅Π½ΠΈΡ Π°Π±ΠΈΡΡΡΠΈΠ΅Π½ΡΠ°ΠΌΠΈ ΠΎΡΡΠ°Π΅ΡΡΡ Π·Π½Π°ΡΠΈΠΌΠΎΠΉ ΠΏΡΠΎΠ±Π»Π΅ΠΌΠΎΠΉ Π΄Π»Ρ Π½ΠΈΡ
ΠΈ Π² ΡΠ²ΡΠ·ΠΈ Ρ ΡΡΠΈΠΌ ΠΏΠ΅ΡΠ΅Π΄ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΠΌΠΈ Π²ΡΡΠ°Π΅Ρ Π·Π°Π΄Π°ΡΠ° Π΄Π°ΡΡ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΡ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°ΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ
ΡΡΠ°ΡΡΠ΅ΠΊΠ»Π°ΡΡΠ½ΠΈΠΊΠΎΠ², Π±ΡΠ΄ΡΡΠΈΡ
Π°Π±ΠΈΡΡΡΠΈΠ΅Π½ΡΠΎΠ².ΠΠ»Ρ ΠΎΡΠ²Π΅ΡΠ° Π½Π° ΡΡΠΈ Π²ΠΎΠΏΡΠΎΡΡ ΡΠΎΡΡΡΠ΄Π½ΠΈΠΊΠ°ΠΌΠΈ ΡΠΎΡΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠ°ΠΊΡΠ»ΡΡΠ΅ΡΠ° ΠΠΠ£ ΠΈΠΌΠ΅Π½ΠΈ Π.Π. ΠΠΎΠΌΠΎΠ½ΠΎΡΠΎΠ²Π° Π±ΡΠ»ΠΎ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΡΠ΅Π΄ΠΈ ΡΡΠ°ΡΡΠ΅ΠΊΠ»Π°ΡΡΠ½ΠΈΠΊΠΎΠ² ΠΌΠΎΡΠΊΠΎΠ²ΡΠΊΠΈΡ
ΡΠΊΠΎΠ». Π ΡΡΠ°ΡΡΠ΅ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Ρ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ ΡΠ°Π·Π½ΡΡ
Π»Π΅Ρ ΡΠ΄ΠΎΠ²Π»Π΅ΡΠ²ΠΎΡΠ΅Π½Π½ΠΎΡΡΠΈ ΡΡΠΎΠ²Π½Π΅ΠΌ ΠΏΠΎΠ»ΡΡΠ°Π΅ΠΌΠΎΠ³ΠΎ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ, ΠΌΠΎΡΠΈΠ²ΠΎΠ² Π²ΡΠ±ΠΎΡΠ° Π±ΡΠ΄ΡΡΠ΅Π³ΠΎ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ ΡΠΊΠΎΠ»ΡΠ½ΠΈΠΊΠ°ΠΌΠΈ ΡΡΠ°ΡΡΠΈΡ
ΠΊΠ»Π°ΡΡΠΎΠ², ΡΠ΅Π½Π½ΠΎΡΡΠ½ΡΡ
ΠΎΡΠΈΠ΅Π½ΡΠ°ΡΠΈΠΉ ΠΌΠΎΠ»ΠΎΠ΄Π΅ΠΆΠΈ. ΠΡΠ»ΠΈ Π²ΡΠ΄Π΅Π»Π΅Π½Ρ ΠΎΡΠ½ΠΎΠ²Π½ΡΠ΅ ΡΠ°ΠΊΡΠΎΡΡ, Π²Π»ΠΈΡΡΡΠΈΠ΅ Π½Π° Π²ΡΠ±ΠΎΡ ΡΡΠΎΠ²Π½Ρ ΠΆΠ΅Π»Π°Π΅ΠΌΠΎΠ³ΠΎ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ ΠΈ ΡΡΠ΅Π±Π½ΠΎΠ³ΠΎ Π·Π°Π²Π΅Π΄Π΅Π½ΠΈΡ, Π° ΡΠ°ΠΊΠΆΠ΅ Π±Π°Π·ΠΎΠ²ΡΠ΅ ΠΌΠΎΠ΄Π΅Π»ΠΈ-ΡΠ΅Π»ΠΈ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΡ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ, ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΠ΅ΠΌΡΠ΅ ΠΌΠΎΠ»ΠΎΠ΄ΡΠΌΠΈ Π»ΡΠ΄ΡΠΌΠΈ ΠΏΡΠΈ Π²ΡΠ±ΠΎΡΠ΅ ΠΆΠΈΠ·Π½Π΅Π½Π½ΠΎΠ³ΠΎ ΠΏΡΡΠΈ. ΠΠ° ΠΎΡΠ½ΠΎΠ²Π΅ ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ
Π΄Π°Π½Π½ΡΡ
ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠΆΠ΄Π΅Π½Π° Π·Π½Π°ΡΠΈΠΌΠΎΡΡΡ Π²ΡΡΡΠ΅Π³ΠΎ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ Π΄Π»Ρ Π±ΡΠ΄ΡΡΠΈΡ
Π°Π±ΠΈΡΡΡΠΈΠ΅Π½ΡΠΎΠ² ΠΈ ΡΡΡΠΎΠΉΡΠΈΠ²ΡΠΉ ΡΠΎΡΡ ΡΠ΅Π½Π΄Π΅Π½ΡΠΈΠΈ ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½ΠΈΡ ΠΏΠΎΡΡΠ΅Π±ΠΈΡΠ΅Π»ΡΡΠΊΠΎΠ³ΠΎ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ ΠΌΠΎΠ»ΠΎΠ΄Π΅ΠΆΠΈ, ΠΎΡΠΈΠ΅Π½ΡΠ°ΡΠΈΠΈ Π² ΡΠ²ΠΎΠΈΡ
ΠΆΠΈΠ·Π½Π΅Π½Π½ΡΡ
ΡΡΡΠ°ΡΠ΅Π³ΠΈΡΡ
Π½Π° Π΄ΠΎΡΡΠΈΠΆΠ΅Π½ΠΈΠ΅ ΡΡΠΏΠ΅Ρ
Π° ΠΈ Π²ΡΡΠΎΠΊΠΎΠ³ΠΎ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΠΎΠ³ΠΎ Π΄ΠΎΡΡΠ°ΡΠΊΠ°, ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Π½ΠΎΠ³ΠΎ ΡΠΎΡΠΈΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΡΠ°ΡΡΡΠ°
The social adaptation of caregivers for the patients with parkinsonism
In the investigations a few factors were estimated influencing on the quality of life of caregivers for the patients with the advance and late stages of PD. We studied social adaptation level using with Glozmanβs scale, clinical features of patients with PD were estimated with UPDRS, Schwab-Englandβs scale, Bartel index, autonomic impairmentβs scale, scale of orthostatic hypotension, Addenbrookeβs scale, NPI, Cornellβs scale of depression with dementia, The main factors determining the social adaptation of caregivers were the severity of PD, especially, autonomic, cognitive, psychotic impairments in patients with PD, as well as limitations in the professional, family and household sectors, leisure, emotional status changes caused by the necessity of patient care.Π ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΈ ΠΎΡΠ΅Π½ΠΈΠ²Π°Π»ΠΈΡΡ ΡΠ°ΠΊΡΠΎΡΡ, Π²Π»ΠΈΡΡΡΠΈΠ΅ Π½Π° ΡΠΎΡΠΈΠ°Π»ΡΠ½ΡΡ Π°Π΄Π°ΠΏΡΠ°ΡΠΈΡ Π»ΠΈΡ, ΡΡ
Π°ΠΆΠΈΠ²Π°ΡΡΠΈΡ
Π·Π° ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ°ΠΌΠΈ Ρ 3-5 ΡΡΠ°Π΄ΠΈΡΠΌΠΈ Π±ΠΎΠ»Π΅Π·Π½ΠΈ ΠΠ°ΡΠΊΠΈΠ½ΡΠΎΠ½Π°. ΠΠ»Ρ ΠΎΡΠ΅Π½ΠΊΠΈ ΡΡΠΎΠ²Π½Ρ ΡΠΎΡΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π°Π΄Π°ΠΏΡΠ°ΡΠΈΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π»Π°ΡΡ ΡΠΊΠ°Π»Π° ΡΠΎΡΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π°Π΄Π°ΠΏΡΠ°ΡΠΈΠΈ ΡΠΎΠ΄ΡΡΠ²Π΅Π½Π½ΠΈΠΊΠΎΠ² ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΠΠ Π.Π. ΠΠ»ΠΎΠ·ΠΌΠ°Π½, Π΄Π»Ρ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΎΡΠ΅Π½ΠΊΠΈ ΡΠΎΡΡΠΎΡΠ½ΠΈΡ Π±ΠΎΠ»ΡΠ½ΡΡ
ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π»ΠΈΡΡ ΡΠ½ΠΈΡΠΈΡΠΈΡΠΎΠ²Π°Π½Π½Π°Ρ ΡΠΊΠ°Π»Π° ΠΠ (UPDRS), ΡΠΊΠ°Π»Π° Π¨Π²Π°Π±Π°-ΠΠ½Π³Π»Π°Π½Π΄Π°, ΠΈΠ½Π΄Π΅ΠΊΡ ΠΠ°ΡΡΠ΅Π»Ρ, ΡΠΊΠ°Π»Π° Π²Π΅Π³Π΅ΡΠ°ΡΠΈΠ²Π½ΡΡ
Π½Π°ΡΡΡΠ΅Π½ΠΈΠΉ, ΠΎΡΡΠΎΡΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π³ΠΈΠΏΠΎΡΠ΅Π½Π·ΠΈΠΈ, ΠΠ΄Π΅Π½Π±ΡΡΠΊΡΠΊΠ°Ρ ΠΊΠΎΠ³Π½ΠΈΡΠΈΠ²Π½Π°Ρ ΡΠΊΠ°Π»Π°, ΠΠΎΡΠ½Π΅Π»ΡΡΠΊΠ°Ρ ΡΠΊΠ°Π»Π° Π΄Π΅ΠΏΡΠ΅ΡΡΠΈΠΈ ΠΏΡΠΈ Π΄Π΅ΠΌΠ΅Π½ΡΠΈΠΈ, ΡΠΊΠ°Π»Π° NPI. ΠΡΠ½ΠΎΠ²Π½ΡΠΌΠΈ ΡΠ°ΠΊΡΠΎΡΠ°ΠΌΠΈ, ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΡΡΠΈΠΌΠΈ ΡΠΎΡΡΠΎΡΠ½ΠΈΠ΅ ΡΠΎΡΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π°Π΄Π°ΠΏΡΠ°ΡΠΈΠΈ ΡΡ
Π°ΠΆΠΈΠ²Π°ΡΡΠΈΡ
Π»ΠΈΡ ΡΠ²ΠΈΠ»ΠΈΡΡ ΡΡΠΆΠ΅ΡΡΡ ΡΠΈΠΌΠΏΡΠΎΠΌΠΎΠ² ΠΏΠ°ΡΠΊΠΈΠ½ΡΠΎΠ½ΠΈΠ·ΠΌΠ°, ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎ Π΄Π²ΠΈΠ³Π°ΡΠ΅Π»ΡΠ½ΡΡ
Π½Π°ΡΡΡΠ΅Π½ΠΈΠΉ, ΠΏΡΠΈΡ
ΠΎΡΠΈΡΠ΅ΡΠΊΠΈΠ΅, Π²Π΅Π³Π΅ΡΠ°ΡΠΈΠ²Π½ΡΠ΅ ΠΈ ΠΊΠΎΠ³Π½ΠΈΡΠΈΠ²Π½ΡΠ΅ ΡΠ°ΡΡΡΡΠΎΠΉΡΡΠ²Π° Π±ΠΎΠ»ΡΠ½ΡΡ
Ρ ΠΠ, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΎΠ³ΡΠ°Π½ΠΈΡΠ΅Π½ΠΈΡ Π² ΠΏΡΠΎΡΠ΅ΡΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠΉ, ΡΠ΅ΠΌΠ΅ΠΉΠ½ΠΎ-Π±ΡΡΠΎΠ²ΠΎΠΉ ΡΡΠ΅ΡΠ°Ρ
, Π΄ΠΎΡΡΠ³Π΅, ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ ΡΠΌΠΎΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΡΠ°ΡΡΡΠ°, Π²ΡΠ·Π²Π°Π½Π½ΡΠ΅ Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎΡΡΡΡ ΡΡ
ΠΎΠ΄Π° Π·Π° Π±ΠΎΠ»ΡΠ½ΡΠΌ
Heterogeneity of speech disorders in Parkinsonβs disease: potential for classification, diagnostics and therapy
Introduction.Β Speech disorders in Parkinsonβs disease are a very common clinical sign. The structure of speech disorders is at the moment not fully understood, there is no unified approach to classification, therapy effects have not been studied.Materials and methods:Β 324 PD patients were primarily included in the study, and from those the patients showing clinically significant speech disorders (22,4%) were selected. All the patients were assessed for motor disorders (UPDRS part 3), cognitive disorders (Addenbrookeβs cognitive examination), as well as affective disorders.Results:Β by means of cluster analysis we identified 4 subtypes of speech disorders as dysphasia (adynamic, disprosodic, constructive, and logopenic). None of the forms was associated with parkinsonism severity and general severity of cognitive impairment, which allowed to consider dysphasia as a separate clinical syndrome. Disprosodic dysphasia differentiated by severity of axial symptoms (F value = 3.279, p < 0,05), adynamic dysphasia was associated with more pronounced apathy (F value = 4,2, p < 0,01), constructive dysphasia β with impairment of visual-spatial functioning (F value 29,93, p<0,0001), while logopenic dysphasia was associated with more severe attention deficiency.Conclusion:Β Speech disorders in PD are heterogeneous and can be regarded as manifestations of dysphasia. Identification of various subtypes will allow for optimizing the treatment of PD patients