Edge-guided image gap interpolation using multi-scale transformation

This paper presents improvements in image gap restoration through the incorporation of edge-based directional interpolation within multi-scale pyramid transforms. Two types of image edges are reconstructed: 1) the local edges or textures, inferred from the gradients of the neighboring pixels and 2) the global edges between image objects or segments, inferred using a Canny detector. Through a process of pyramid transformation and downsampling, the image is progressively transformed into a series of reduced size layers until at the pyramid apex the gap size is one sample. At each layer, an edge skeleton image is extracted for edge-guided interpolation. The process is then reversed; from the apex, at each layer, the missing samples are estimated (an iterative method is used in the last stage of upsampling), up-sampled, and combined with the available samples of the next layer. Discrete cosine transform and a family of discrete wavelet transforms are utilized as alternatives for pyramid construction. Evaluations over a range of images, in regular and random loss pattern, at loss rates of up to 40%, demonstrate that the proposed method improves peak-signal-to-noise-ratio by 1–5 dB compared with a range of best-published works

A novel framework for high-quality voice source analysis and synthesis

The analysis, parameterization and modeling of voice source estimates obtained via inverse filtering of recorded speech are some of the most challenging areas of speech processing owing to the fact humans produce a wide range of voice source realizations and that the voice source estimates commonly contain artifacts due to the non-linear time-varying source-filter coupling. Currently, the most widely adopted representation of voice source signal is Liljencrants-Fant's (LF) model which was developed in late 1985. Due to the overly simplistic interpretation of voice source dynamics, LF model can not represent the fine temporal structure of glottal flow derivative realizations nor can it carry the sufficient spectral richness to facilitate a truly natural sounding speech synthesis. In this thesis we have introduced Characteristic Glottal Pulse Waveform Parameterization and Modeling (CGPWPM) which constitutes an entirely novel framework for voice source analysis, parameterization and reconstruction. In comparative evaluation of CGPWPM and LF model we have demonstrated that the proposed method is able to preserve higher levels of speaker dependant information from the voice source estimates and realize a more natural sounding speech synthesis. In general, we have shown that CGPWPM-based speech synthesis rates highly on the scale of absolute perceptual acceptability and that speech signals are faithfully reconstructed on consistent basis, across speakers, gender. We have applied CGPWPM to voice quality profiling and text-independent voice quality conversion method. The proposed voice conversion method is able to achieve the desired perceptual effects and the modified speech remained as natural sounding and intelligible as natural speech. In this thesis, we have also developed an optimal wavelet thresholding strategy for voice source signals which is able to suppress aspiration noise and still retain both the slow and the rapid variations in the voice source estimate.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

CMB Temperature Polarization Correlation and Primordial Gravitational Waves

We examine the use of the CMB's TE cross correlation power spectrum as a complementary test to detect primordial gravitational waves (PGWs). The first method used is based on the determination of the lowest multipole, $\ell_0$, where the TE power spectrum, $C_{\ell}^{TE}$, first changes sign. The second method uses Wiener filtering on the CMB TE data to remove the density perturbations contribution to the TE power spectrum. In principle this leaves only the contribution of PGWs. We examine two toy experiments (one ideal and another more realistic) to see their ability to constrain PGWs using the TE power spectrum alone. We found that an ideal experiment, one limited only by cosmic variance, can detect PGWs with a ratio of tensor to scalar metric perturbation power spectra $r=0.3$ at 99.9% confidence level using only the TE correlation. This value is comparable with current constraints obtained by WMAP based on the $2\sigma$ upper limits to the B-mode amplitude. We demonstrate that to measure PGWs by their contribution to the TE cross correlation power spectrum in a realistic ground based experiment when real instrumental noise is taken into account, the tensor-to-scalar ratio, $r$, should be approximately three times larger.Comment: 13 pages, 13 figures, version matches published version. Combined with 0710.365

Dynamical correlations in electronic transport through a system of coupled quantum dots

Current auto- and cross-correlations are studied in a system of two capacitively coupled quantum dots. We are interested in a role of Coulomb interaction in dynamical correlations, which occur outside the Coulomb blockade region (for high bias). After decomposition of the current correlation functions into contributions between individual tunneling events, we can show which of them are relevant and lead to sub-/supper-Poissonian shot noise and negative/positive cross-correlations. The results are differentiated for a weak and strong inter-dot coupling. Interesting results are for the strong coupling case when electron transfer in one of the channel is strongly correlated with charge drag in the second channel. We show that cross-correlations are non-monotonic functions of bias voltage and they are in general negative (except some cases with asymmetric tunnel resistances). This is effect of local potential fluctuations correlated by Coulomb interaction, which mimics the Pauli exclusion principle

Statins use and risk of breast cancer recurrence and death: A systematic review and meta-analysis of observational studies

Purpose. Statins are widely prescribed drugs for lowering cholesterol. Some studies have suggested that statins can prevent breast cancer recurrence and reduce mortality rate. However they are not conclusive. Present systematic review and meta-analysis of published cohort studies was conducted to determine the effects of statins intake and risk of breast cancer recurrence and mortality rate. Methods. Online databases (PubMed, Embase, Scopus, EBSCO and Cochrane Collaboration) were searched through October 2014. Pooled relative risks and 95 confidence intervals were calculated with random-effects. Results. A total of 8 cohort studies (4 for recurrence 2 for mortality and 2 for both) involving 124669 participants with breast cancer were eligible. Our results suggest a significant reduction in recurrence (OR= 0.79. I2= 38) and death (OR = 0.84, I2 = 8.58) among statin users. Conclusion. Our meta-analysis suggests that breast cancer patients will benefit from statin intake, however from these cohorts we are unable to differentiate between various statins in terms of effectiveness and duration of use. We highly propose conducting randomized clinical trials. © 2016, Canadian Society for Pharmaceutical Sciences. All rights reserved

Impact of metoclopramide on image quality in myocardial perfusion imaging

Background: The effectiveness of metoclopramide in reducing gastrointestinal-induced artifacts in myocardial perfusion imaging (MPI) is a subject of debate. We examined the significance of this pharmacological intervention in the quality of images obtained from MPI studies. Patients and Methods: A total of 211 suspected or known cases with coronary artery disease routinely referred to our nuclear medicine department for MPI were randomly assigned to group A and group B. Group A (N=125) comprised patients who received 10 mg of metoclopramide orally after the injection of the radiotracer technetium-99m-labeled methoxyisobutyl isonitril (Tc-MIBI) 1 h before image acquisition, and group B (N=86) comprised patients who did not receive any pharmacological intervention and were considered the control group. All the scans in each group were assessed in the rest phase of a routine 2-day protocol. The single-photon emission computerized tomography (SPECT) images were visually evaluated in terms of extracardiac activities and their effects on image quality by three nuclear medicine physicians, who were blinded to the details of the protocol. Results: Of the 125 patients who had received metoclopramide, 16 (13%) had nonacceptable, 72 (57.6%) had acceptable (interpretable), and 37 (29.6%) had good image quality. The image quality in group B was nonacceptable in 10 (11.23%), acceptable in 48 (50.23%), and good in 28 (33.56%) patients. The overall interobserver agreement was good (κ: 0.6-0.9, P<0.05) among the three readers. Conclusion: There was no statistically significant difference in terms of MPI-SPECT image quality between patients who received metoclopramide and those in the control group. Metoclopramide, therefore, did not exert a remarkable effect on the quality of our MPI scans. © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins

Charge fluctuations and feedback effect in shot noise in a Y-terminal system

We investigate a dynamical Coulomb blockade effect and its role in the enhancement of current-current correlations in a three-terminal device with a multilevel splitter, as well as with two quantum dots. Spectral decomposition analysis shows that in the Y-terminal system with a two level ideal splitter, charge fluctuations at a level with a lowest outgoing tunneling rate are responsible for a super-Poissonian shot noise and positive cross-correlations. Interestingly, for larger source-drain voltages, electrons are transferred as independent particles, when three levels participate in transport, and double occupancy is allowed. We can explain compensation of the current correlations as the interplay between different bunching and antibunching processes by performing a spectral decomposition of the correlation functions for partial currents flowing through various levels. In the system with two quantum dots acting as a splitter, a long range feedback effect of fluctuating potentials leads to the dynamical Coulomb blockade and an enhancement of shot noise.Comment: 15 pages, 8 figure

Arrhythmic risk profile and outcomes of patients undergoing cardiac sympathetic denervation for recurrent monomorphic ventricular tachycardia after ablation

Background Cardiac sympathetic denervation (CSD) has been used as a bailout strategy for refractory ventricular tachycardia (VT). Risk of VT recurrence in patients with scar-related monomorphic VT referred for CSD and the extent to which CSD can modify this risk is unknown. We aimed to quantify arrhythmia recurrence risk and impact of CSD in this population. Methods and Results Adjusted competing risk time to event models were developed to adjust for risk of VT recurrence and sustained VT/implantable cardioverter-defibrillator shocks after VT ablation based on patient comorbidities at the time of VT ablation. Adjusted VT and implantable cardioverter-defibrillator shock recurrence rates were estimated for the subgroup who subsequently required CSD after ablation. The expected adjusted recurrence rates were then compared with the observed rates after CSD. Data from 381 patients with scar-mediated monomorphic VT who underwent VT ablation were analyzed, excluding patients with polymorphic VT. Sixty eight patients underwent CSD for recurrent VT. CSD reduced the expected adjusted VT recurrence rate by 36% (expected rate of 5.61 versus observed rate of 3.58 per 100 person-months, P=0.01) and the sustained VT/implantable cardioverter-defibrillator shock rates by 34% (expected rate of 4.34 versus observed 2.85 per 100 person-months, P=0.03). The median number of sustained VT/implantable cardioverter-defibrillator shocks in the year before versus the year after CSD was reduced by 90% (10 versus 1, P&lt;0.0001). Conclusions Patients referred for CSD for refractory scar-mediated monomorphic VT are at a higher risk of VT recurrence after ablation as compared with those not requiring CSD, mostly because of their cardiac comorbidities. CSD significantly reduced both the expected risk of recurrences and VT burden