Childhood Depression in Family Narratives

BACKGROUND: The family narratives are true contextual cues in the representation of the experiences of illness of depressive child. The family members use healthcare services in an attempt to understand the disease so that describe the everyday practices in the living with the child. OBJECTIVE: This original article aims to present childhood depression with its various nuances and its many consequences in the family context. METHODS: The universe of this study involved 24 families in the age group ranging from 45 to 70 years who searched the care services at Children's Psychosocial Care Center (CAPSi). Through the records, a survey of the family members was performed, from case reports, in the course of medical and psychological consultations. This is a purposive sample, which was selected by approximation the inclusion criteria, a sample of 12 family members of both sexes. The attention focused on the use of narrative interview - which is recognized as a genre of sociolinguistic research - fully recorded. RESULTS: The family member has its convivial trajectory with the disease through a specific identity and enunciation with the child. The family narratives show up symbolic portraits to the rescue of the guiding elements of the depressive situation. The family narratives are shown as spaces of reinterpretation of pain and psychological distress. The disorder explained in the narratives of childhood depression inserted in understanding plays a crucial role in exposing the intensity of pain and psychological distress. CONCLUSION: It is fundamental important in clinical care the psychiatric practice inserted into the historical and social context of the family members who have their own living narrative with the disease

Electroconvulsive therapy use in adolescents: a systematic review

Abstract\ud \ud \ud \ud Background\ud \ud Considered as a moment of psychological vulnerability, adolescence is remarkably a risky period for the development of psychopathologies, when the choice of the correct therapeutic approach is crucial for achieving remission. One of the researched therapies in this case is electroconvulsive therapy (ECT). The present study reviews the recent and classical aspects regarding ECT use in adolescents.\ud \ud \ud \ud Methods\ud \ud Systematic review, performed in November 2012, conformed to the PRISMA statement.\ud \ud \ud \ud Results\ud \ud From the 212 retrieved articles, only 39 were included in the final sample. The reviewed studies bring indications of ECT use in adolescents, evaluate the efficiency of this therapy regarding remission, and explore the potential risks and complications of the procedure.\ud \ud \ud \ud Conclusions\ud \ud ECT use in adolescents is considered a highly efficient option for treating several psychiatric disorders, achieving high remission rates, and presenting few and relatively benign adverse effects. Risks can be mitigated by the correct use of the technique and are considered minimal when compared to the efficiency of ECT in treating psychopathologies

The Importance Of Neuronal Plasticity In The Prognosis Of Cases Of Cerebral Ischemia: A Systematic Review

Background: Neuronal plasticity is the capacity that the neurons have to make new connections and enable new ways of transmitting information. Under this context, new methodologies are being addressed in order to measure how important this neuronal capacity is in the process of full recovery of learning in subjects who suffered damage from cerebral ischemia.Methods: A systematic review was performed on the online databases: Medical Literature Analysis and Retrieval System Online (MEDLINE) and Scopus, between 1998 and 2014. The MeSH (Medical Subject Headings) descriptors used in this review were: "neuronal plasticity", "brain ischemia" and "learning". We found 164 articles that, when screened, resulted in 46 articles that met the criteria of evidence and were included in this review.Results: There are several ways available in the literature to increase neuronal plasticity to keep the learning process after bad conformations resulting from cerebral ischemia. We highlighted the most elucidated: those promoted by SMe1EC2 antioxidant, which brings therapeutic benefits when neuronal plasticity is impaired; and Atorvastatin, a statin which facilitates recovery of spatial learning. It is further observed that the body has a number of intrinsic devicessuch as the endogenous compensatory mechanisms that contribute to the development of neuronal plasticity when there is brain damage caused by ischemia.Conclusion: The improvement of neuronal plasticity appears in several studies mapped as a new and still little explored possibility of treatment of damages caused by brain processes of oxygen deprivation. Multiple devices, endogenous and exogenous, that promote an increase in neuronal plasticity, are being elucidated in an attempt to promote the full recovery of the learning process, decreased by brain damage from ischemic processes. Thus, it is pointed the necessity of scientific studies that allows to define and maximize the potentials of the neuronal plasticity

Estudo de algoritmos para o problema de otimização de vazão de poços de petróleo

Petroleum Engineer activity is constantly enrolled on a series of optimization problems on many contexts, as, for instance, defining efficient and optimized projects on petroleum reserves development. However, there is an extreme difficulty on resolution of exploration and production (P&E) optimization problems, since they are often complex, with high degree of nonlinearity, presenting high uncertain number, and huge computational cost involved. Among them, there is the problem of determining the best throughput distribution among the wells of a petroleum production platform that achieves the biggest financial profitability of an E&P project, here named Petroleum Well Throughput Optimization Problem (PWTOP). In order to deal with PWTOP, some continuous optimization algorithms that deals with linearity restrictions present on the problem were studied, that are the Derivative Free Optimization (DFO), the Generating Set Search (GSS), and the Differential Evolution (DE). DFO is a sequential algorithm, whereas GSS and DE are parallel algorithms. Two case studies are also presented that represents synthetic petroleum fields. The results show how the studied algorithms behave on dealing with PWTOP for the two case studies, comparing experimental results obtained on optimized financial values, execution times and amount of objective function evaluation. Concludes, lastly, that, for the simplest case study, GSS had the best result, and for the most complex case study, more like real reservoirs, DE stood outA atividade de Engenharia de Petróleo está rotineiramente envolvida em uma série de problemas de otimização em variados contextos, como definir projetos otimizados e eficientes na produção e no desenvolvimento de reservas de petróleo. Entretanto, há uma extrema dificuldade na resolução de problemas de otimização de exploração e produção (E&P), uma vez que são problemas frequentemente complexos, com elevado grau de não-linearidade, que apresentam alto número de incertezas e com enorme custo computacional envolvido. Dentre eles, está o problema de determinar a melhor distribuição de vazões entre os poços de uma plataforma de produção de petróleo capaz de resultar em um projeto de E&P de maior rentabilidade financeira, aqui denominado Problema de Otimização de Vazão de Poços de Petróleo (POVPP). Para tratar o POVPP, foram estudados alguns algoritmos de otimização contínua que possam lidar com as restrições lineares presentes no problema, que são o Otimização sem Derivadas (Derivative Free Optimization DFO), o Busca por Conjunto Gerador (Generating Set Search GSS) e o Evolução Diferencial (Differential Evolution DE). O DFO é um algoritmo sequencial, enquanto que o GSS e o DE são algoritmos paralelos. Também são apresentados dois estudos de caso que representam campos de petróleo sintéticos. Os resultados mostram como os algoritmos estudados se comportam ao tratar o POVPP para os dois estudos de caso, comparando-se dados obtidos de valores financeiros otimizados, tempos de execução e quantidade de avaliações da função objetivo. Conclui-se, por fim, que, para o estudo de caso simples, o GSS teve o melhor resultado, e para o estudo de caso mais complexo, mais semelhante a reservatórios reais, o DE se sobressai

CUIDADO FARMACÊUTICO NO ADOLESCENTE PORTADOR DO DIABETES MELLITUS TIPO I

O cuidado farmacêutico possui por finalidade, aumentar a efetividade do tratamento medicamentoso. Sua atuação inclui uma somatória de atitudes, comportamentos, corresponsabilidades e habilidades na prestação da farmacoterapia, com o objetivo de alcançar resultados terapêuticos eficientes e seguros privilegiando a saúde e a qualidade de vida do paciente. Diante desse contexto torna-se uma ferramenta importante para o acompanhamento farmacoterapêutico em pacientes com Diabetes mellitus tipo I, uma vez que o indivíduo com essa síndrome precisa ser amparado, pois trata-se de uma patologia complexa, que envolve cuidados com esquema posológico, armazenamento de insulina, e mudanças nos hábitos de vida

The three isoforms of nitric oxide synthase distinctively affect mouse nocifensive behavior

Nitric oxide synthases (NOSs) have been shown to modulate thermal hyperalgesia and mechanical hypersensitivity in inflammatory and neuropathic pain. However, little is known about the effect of NOSs on baseline function of sensory nerve fibers. Using genetic deficiency and pharmacologic inhibition of NOSs, we examined the impact of the three isoforms NOS1, NOS2, and NOS3 on baseline nocifensive behavior by measuring current vocalization threshold in response to electrical stimulation at 5, 250, 2000 Hz that preferentially stimulate C, Aδ, and Aβ fibers. In response to 5, 250 and 2000 Hz, NOS1-deficient animals had significantly higher current vocalization thresholds compared with wild-type. Genetic deficiency of NOS2 was associated with higher current vocalization thresholds in response to 5 Hz (C-fiber) stimulation. In contrast, NOS3-deficient animals had an overall weak trend toward lower current vocalization thresholds at 5 Hz and significantly lower current vocalization threshold compared with wild-type animals at 250 and 2000 Hz. Therefore, NOSs distinctively affect baseline mouse current vocalization threshold and appear to play a role on nocifensive response to electrical stimulation of sensory nerve fibers