366 research outputs found
Static versus dynamic fluctuations in the one-dimensional extended Hubbard model
The extended Hubbard Hamiltonian is a widely accepted model for uncovering
the effects of strong correlations on the phase diagram of low-dimensional
systems, and a variety of theoretical techniques have been applied to it. In
this paper the world-line quantum Monte Carlo method is used to study spin,
charge, and bond order correlations of the one-dimensional extended Hubbard
model in the presence of coupling to the lattice. A static alternating lattice
distortion (the ionic Hubbard model) leads to enhanced charge density wave
correlations at the expense of antiferromagnetic order. When the lattice
degrees of freedom are dynamic (the Hubbard-Holstein model), we show that a
similar effect occurs even though the charge asymmetry must arise
spontaneously. Although the evolution of the total energy with lattice coupling
is smooth, the individual components exhibit sharp crossovers at the phase
boundaries. Finally, we observe a tendency for bond order in the region between
the charge and spin density wave phases.Comment: Corrected typos. (10 pages, 9 figures
Quantum Monte Carlo study of the visibility of one-dimensional Bose-Fermi mixtures
The study of ultracold optically trapped atoms has opened new vistas in the
physics of correlated quantum systems. Much attention has now turned to
mixtures of bosonic and fermionic atoms. A central puzzle is the disagreement
between the experimental observation of a reduced bosonic visibility , and quantum Monte Carlo (QMC) calculations which show
increasing. In this paper, we present QMC simulations which evaluate the
density profiles and of mixtures of bosons and fermions in
one-dimensional optical lattices. We resolve the discrepancy between theory and
experiment by identifying parameter regimes where is reduced, and
where it is increased. We present a simple qualitative picture of the different
response to the fermion admixture in terms of the superfluid and
Mott-insulating domains before and after the fermions are included. Finally, we
show that exhibits kinks which are tied to the domain evolution
present in the pure case, and also additional structure arising from the
formation of boson-fermion molecules, a prediction for future experiments.Comment: 4 pages, 6 figure
Engineered 2D Ising interactions on a trapped-ion quantum simulator with hundreds of spins
The presence of long-range quantum spin correlations underlies a variety of
physical phenomena in condensed matter systems, potentially including
high-temperature superconductivity. However, many properties of exotic strongly
correlated spin systems (e.g., spin liquids) have proved difficult to study, in
part because calculations involving N-body entanglement become intractable for
as few as N~30 particles. Feynman divined that a quantum simulator - a
special-purpose "analog" processor built using quantum particles (qubits) -
would be inherently adept at such problems. In the context of quantum
magnetism, a number of experiments have demonstrated the feasibility of this
approach. However, simulations of quantum magnetism allowing controlled,
tunable interactions between spins localized on 2D and 3D lattices of more than
a few 10's of qubits have yet to be demonstrated, owing in part to the
technical challenge of realizing large-scale qubit arrays. Here we demonstrate
a variable-range Ising-type spin-spin interaction J_ij on a naturally occurring
2D triangular crystal lattice of hundreds of spin-1/2 particles (9Be+ ions
stored in a Penning trap), a computationally relevant scale more than an order
of magnitude larger than existing experiments. We show that a spin-dependent
optical dipole force can produce an antiferromagnetic interaction J_ij ~
1/d_ij^a, where a is tunable over 0<a<3; d_ij is the distance between spin
pairs. These power-laws correspond physically to infinite-range (a=0),
Coulomb-like (a=1), monopole-dipole (a=2) and dipole-dipole (a=3) couplings.
Experimentally, we demonstrate excellent agreement with theory for 0.05<a<1.4.
This demonstration coupled with the high spin-count, excellent quantum control
and low technical complexity of the Penning trap brings within reach simulation
of interesting and otherwise computationally intractable problems in quantum
magnetism.Comment: 10 pages, 10 figures; article plus Supplementary Material
Intranasal Peptide-Based FpvA-KLH Conjugate Vaccine Protects Mice From Pseudomonas aeruginosa Acute Murine Pneumonia
Pseudomonas aeruginosa is an opportunistic pathogen causing acute and chronic respiratory infections associated with morbidity and mortality, especially in patients with cystic fibrosis. Vaccination against P. aeruginosa before colonization may be a solution against these infections and improve the quality of life of at-risk patients. To develop a vaccine against P. aeruginosa, we formulated a novel peptide-based P. aeruginosa subunit vaccine based on the extracellular regions of one of its major siderophore receptors, FpvA. We evaluated the effectiveness and immunogenicity of the FpvA peptides conjugated to keyhole limpet hemocyanin (KLH) with the adjuvant curdlan in a murine vaccination and challenge model. Immunization with the FpvA-KLH vaccine decreased the bacterial burden and lung edema after P. aeruginosa challenge. Vaccination with FpvA-KLH lead to antigen-specific IgG and IgM antibodies in sera, and IgA antibodies in lung supernatant. FpvA-KLH immunized mice had an increase in recruitment of CD11b+ dendritic cells as well as resident memory CD4+ T cells in the lungs compared to non-vaccinated challenged mice. Splenocytes isolated from vaccinated animals showed that the FpvA-KLH vaccine with the adjuvant curdlan induces antigen-specific IL-17 production and leads to a Th17 type of immune response. These results indicate that the intranasal FpvA-KLH conjugate vaccine can elicit both mucosal and systemic immune responses. These observations suggest that the intranasal peptide-based FpvA-KLH conjugate vaccine with curdlan is a potential vaccine candidate against P. aeruginosa pneumonia
Topological semimetal in a fermionic optical lattice
Optical lattices play a versatile role in advancing our understanding of
correlated quantum matter. The recent implementation of orbital degrees of
freedom in chequerboard and hexagonal optical lattices opens up a new thrust
towards discovering novel quantum states of matter, which have no prior analogs
in solid state electronic materials. Here, we demonstrate that an exotic
topological semimetal emerges as a parity-protected gapless state in the
orbital bands of a two-dimensional fermionic optical lattice. The new quantum
state is characterized by a parabolic band-degeneracy point with Berry flux
, in sharp contrast to the flux of Dirac points as in graphene. We
prove that the appearance of this topological liquid is universal for all
lattices with D point group symmetry as long as orbitals with opposite
parities hybridize strongly with each other and the band degeneracy is
protected by odd parity. Turning on inter-particle repulsive interactions, the
system undergoes a phase transition to a topological insulator whose
experimental signature includes chiral gapless domain-wall modes, reminiscent
of quantum Hall edge states.Comment: 6 pages, 3 figures and Supplementary Informatio
Comment on the sign of the Casimir force
I show that reflection positivity implies that the force between any mirror
pair of charge-conjugate probes of the quantum vacuum is attractive. This
generalizes a recent theorem of Kenneth and Klich to interacting quantum
fields, to arbitrary semiclassical bodies, and to quantized probes with
non-overlapping wavefunctions. I also prove that the torques on
charge-conjugate probes tend always to rotate them into a mirror-symmetric
position.Comment: 13 pages, 1 figure, Latex file. Several points clarified and
expanded, two references added
Textural variations in Neogene pelagic carbonate ooze at DSDP Site 593, southern Tasman Sea, and their paleoceanographic implications
Changes in Neogene sediment texture in pelagic carbonate-rich oozes on the Challenger Plateau, southern Tasman Sea, are used to infer changes in depositional paleocurrent velocities. The most obvious record of textural change is in the mud:sand ratio. Increases in the sand content are inferred to indicate a general up-core trend towards increasing winnowing of sediments resulting from increasing flow velocity of Southern Component Intermediate Water (SCIW), the forerunner of Antarctic Intermediate Water. In particular, the intervals c. 19-14.5 Ma, c. 9.5-8 Ma, and after 5 Ma are suggested to be times of increased SCIW velocity and strong sediment winnowing. Within the mud fraction, the fine silt to coarse clay sizes from 15.6 to 2 µm make the greatest contribution to the sediments and are composed of nannofossil plates. During extreme winnowing events it is the fine silt to very coarse clay material (13-3 µm) within this range that is preferentially removed, suggesting the 10 µm cohesive silt boundary reported for siliciclastic sediments does not apply to calcitic skeletal grains. The winnowed sediment comprises coccolithophore placoliths and spheres, represented by a mode at 4-7 µm.
Further support for seafloor winnowing is gained from the presence in Hole 593 of a condensed sedimentary section from c. 18 to 14 Ma where the sand content increases to c. 20% of the bulk sample. Associated with the condensed section is a 6 m thick orange unit representing sediments subjected to particularly oxygen-rich, late early to early middle Miocene SCIW. Together these are inferred to indicate increased SCIW velocity resulting in winnowed sediment associated with faster arrival of oxygen-rich surface water subducted to form SCIW. Glacial development of Antarctica has been recorded from many deep-sea sites, with extreme glacials providing the mechanism to increase watermass flow. Miocene glacial zones Mi1b-Mi6 are identified in an associated oxygen isotope record from Hole 593, and correspond with times of particularly invigorated paleocirculation, bottom winnowing, and sediment textural changes
Acceleressence: Dark Energy from a Phase Transition at the Seesaw Scale
Simple models are constructed for "acceleressence" dark energy: the latent
heat of a phase transition occurring in a hidden sector governed by the seesaw
mass scale v^2/M_Pl, where v is the electroweak scale and M_Pl the
gravitational mass scale. In our models, the seesaw scale is stabilized by
supersymmetry, implying that the LHC must discover superpartners with a
spectrum that reflects a low scale of fundamental supersymmetry breaking.
Newtonian gravity may be modified by effects arising from the exchange of
fields in the acceleressence sector whose Compton wavelengths are typically of
order the millimeter scale. There are two classes of models. In the first class
the universe is presently in a metastable vacuum and will continue to inflate
until tunneling processes eventually induce a first order transition. In the
simplest such model, the range of the new force is bounded to be larger than 25
microns in the absence of fine-tuning of parameters, and for couplings of order
unity it is expected to be \approx 100 microns. In the second class of models
thermal effects maintain the present vacuum energy of the universe, but on
further cooling, the universe will "soon" smoothly relax to a matter dominated
era. In this case, the range of the new force is also expected to be of order
the millimeter scale or larger, although its strength is uncertain. A firm
prediction of this class of models is the existence of additional energy
density in radiation at the eV era, which can potentially be probed in
precision measurements of the cosmic microwave background. An interesting
possibility is that the transition towards a matter dominated era has occurred
in the very recent past, with the consequence that the universe is currently
decelerating.Comment: 10 pages, references adde
Design and rationale of a multi-center, pragmatic, open-label randomized trial of antimicrobial therapy - the study of clinical efficacy of antimicrobial therapy strategy using pragmatic design in Idiopathic Pulmonary Fibrosis (CleanUP-IPF) clinical trial
Compelling data have linked disease progression in patients with idiopathic pulmonary fibrosis (IPF) with lung dysbiosis and the resulting dysregulated local and systemic immune response. Moreover, prior therapeutic trials have suggested improved outcomes in these patients treated with either sulfamethoxazole/ trimethoprim or doxycycline. These trials have been limited by methodological concerns. This trial addresses the primary hypothesis that long-term treatment with antimicrobial therapy increases the time-to-event endpoint of respiratory hospitalization or all-cause mortality compared to usual care treatment in patients with IPF. We invoke numerous innovative features to achieve this goal, including: 1) utilizing a pragmatic randomized trial design; 2) collecting targeted biological samples to allow future exploration of 'personalized' therapy; and 3) developing a strong partnership between the NHLBI, a broad range of investigators, industry, and philanthropic organizations. The trial will randomize approximately 500 individuals in a 1:1 ratio to either antimicrobial therapy or usual care. The site principal investigator will declare their preferred initial antimicrobial treatment strategy (trimethoprim 160 mg/ sulfamethoxazole 800 mg twice a day plus folic acid 5 mg daily or doxycycline 100 mg once daily if body weight is < 50 kg or 100 mg twice daily if ≥50 kg) for the participant prior to randomization. Participants randomized to antimicrobial therapy will receive a voucher to help cover the additional prescription drug costs. Additionally, those participants will have 4-5 scheduled blood draws over the initial 24 months of therapy for safety monitoring. Blood sampling for DNA sequencing and genome wide transcriptomics will be collected before therapy. Blood sampling for transcriptomics and oral and fecal swabs for determination of the microbiome communities will be collected before and after study completion. As a pragmatic study, participants in both treatment arms will have limited in-person visits with the enrolling clinical center. Visits are limited to assessments of lung function and other clinical parameters at time points prior to randomization and at months 12, 24, and 36. All participants will be followed until the study completion for the assessment of clinical endpoints related to hospitalization and mortality events. TRIAL REGISTRATION: ClinicalTrials.gov identifier NCT02759120
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