97 research outputs found
Development of human capital in the system of economic categories of work
Today, human capital is one of the main factors in the formation of the knowledge economy, which is the highest stage in the development of an innovative, post-industrial economy.
The development of intellectual and spiritual capabilities of a person, as well as the accumulation of human capital, which has a strong influence on the productivity and quality of labor, becomes one of the priorities for the future development of the state.
This article discusses the development of human capital in the system of economic categories of labor.peer-reviewe
Influence of components structure and composition of binary mixtures of organic compounds on toxicity towards Daphnia Magna
Simplex representation of molecular structure is employed for consensus QSAR analysis of toxicity towards Daphnia magna of sodium salts of Ξ±-alkoxycarbonylsulfuric acids, aliphatic n-alcohols, phenols and their binary mixtures. The structure of a mixture is represented both using descriptors of individual compounds included in the mixture and using novel specific mixture parameters termed unconnected simplexes. The studied dataset included 15 single compounds and 20 mixtures. The logarithm of EC50 (mmole/l) is used as a target function. Aims of the research are the determination of molecular fragments with positive or negative influence on the toxicity and developing QSAR models capable to predict properly the toxicity of new compounds and mixtures from their structure and composition. Successful consensus model based on forty best QSAR models (R2=0,86β¦0,97; Q2=0,74β¦0,96; R2test=0,86β¦0,99) is obtained using different training and test sets
Selective support for the development of regional vocational education services: The Russian experience
Β© 2016, Econjournals. All rights reserved.The paper relevance is reasoned by the optimization of management of regional vocational educational services. Russian regions differ from each other very much by social and economic indicators, as well as the climatic and geographical conditions. The Russian government initiated a number of reforms aimed at ensuring of equal access to vocational educational services and infrastructure across the country. One of the important components of such reforms is a targeted selective support for the development of regional vocational educational services. The paper aims to find out the specifics of selective support for the development of regional vocational educational services. The leading method is the method of action research, providing new information on the management of vocational education in the region and proposing methods for development of regional vocational educational services. The paper presents a selective mechanism to support the development of regional vocational educational services. Principles (consensus and initiative) are defined and methods (legal-regulatory, financial-economic, socio-political, information-communication, private-entrepreneurial, civil- initiative) are identified of selective support for the development of regional vocational educational services. It is found that the selective support for the development of regional vocational educational services is a component of the socio-economic development of the region and the imperative to improve the quality of life of the population. Article Submissions can be useful for research and teaching staff of vocational education, specialists of education authorities and regional authorities
Complex 99mTc-PDA-DTPA for myocardial imaging
The 123I-labeled fatty acids such as 123I-Iodophenylpentadecanoic acid and 123I-Beta-methyliodophenylpentadecanoic acid are the agents used clinically for myocardial imaging. Fatty acids are the major source of energy for the normal myocardium. However, under ischemic conditions the myocardial cells switch to glucose metabolism for their energy needs. Fatty acids undergo prolonged metabolic stunning in patients with reversible ischemia, thereby helping in early diagnosis of coronary artery disease in highrisk patients. High cost andlimited availability of cyclotron-produced 123I, makes 99mTc-labeled fatty acids more desirable for the purpose. In diagnosis the dominant radionuclide is 99mTc. It is estimated that it is involved in about 85% of all imaging procedures in nuclear medicine. The method for preparation of new 99mTc-fatty chemical systems based on modified diethylene triamine pentaacetic acid (DTPA) molecule has been elaborated in this work . The main advantage using DTPA as chelate agent for radioactive label, is the molecule or it's derivative ability to form sufficiently stable complexes with different radioactive metals including technetium-99. Moiety of pentadecanoic acid addition gave the ability to prepare modified complex of DTPA. In a labeling procedure, freshly eluted Na99mTcO4 (20mCi) was added to a mixture of cysteine, stannous chloride, PDK-DTPA and ethanol in a vial. On keeping the reaction mixture at 90 0C for 30 min, [99mTc-PDK-DTPA] radiopharmaceutical was formed. Thereafter, the reaction mixture was cooled over ice and characterized by HPLC. The result of dynamic scintigraphic research showed, that after being injected, the substance is actively acumulated into myocardium. Eventually one can say that modified DTPA-moleculs are functionally suitable for myocardial imaging
ΠΠ‘ΠΠ ΠΠ‘Π‘ΠΠΠ‘ΠΠΠ Π€ΠΠΠΠ£ΠΠ¬Π’Π£Π ΠΠ-Π‘ΠΠΠ Π’ΠΠΠΠ«Π ΠΠΠΠΠΠΠΠ‘ Β«ΠΠΠ’ΠΠ Π Π’Π Π£ΠΠ£ Π ΠΠΠΠ ΠΠΠΒ» ΠΠΠ ΠΠ¦ΠΠΠΠ§ΠΠΠ Π‘Π ΠΠΠ‘Π’ΠΠ Π£Π ΠΠΠΠ― Π‘Π€ΠΠ ΠΠΠ ΠΠΠΠΠΠΠ‘Π’Π ΠΠ ΠΠ€ΠΠ‘Π‘ΠΠΠΠΠΠ¬ΠΠ«Π₯ ΠΠΠΠΠΠ’ΠΠΠ¦ΠΠ Π‘Π’Π£ΠΠΠΠ’ΠΠ-ΠΠΠΠΠΠΠ ΠΠ ΠΠΠ‘Π¦ΠΠΠΠΠΠ Β«Π€ΠΠΠΠ§ΠΠ‘ΠΠΠ― ΠΠ£ΠΠ¬Π’Π£Π ΠΒ»
The problem of estimation of studentsβ professional competence level in βPhysical educationβ is a difficult task to solve. The RWD complex corresponds the demands of the modern pedagogical evaluation and is the universal means of formation of quantitative evaluation of competencies. Analysis of the results shown by students in certain types of tests indicates a relatively weak preparedness for passing the standards of the RWD complex. To create the most favorable conditions for the formation of competence in the discipline βPhysical educationβΒ during the development of the educational program it is necessary to include types of the RWD complex among credit requirements and evaluate them in accordance with the score-rating system.ΠΡΠΎΠ±Π»Π΅ΠΌΠ° ΠΎΡΠ΅Π½ΠΈΠ²Π°Π½ΠΈΡ ΡΡΠΎΠ²Π½Ρ ΡΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½Π½ΠΎΡΡΠΈ ΠΊΠΎΠΌΠΏΠ΅ΡΠ΅Π½ΡΠΈΠΉ ΠΏΠΎ Π΄ΠΈΡΡΠΈΠΏΠ»ΠΈΠ½Π΅ Β«Π€ΠΈΠ·ΠΈΡΠ΅ΡΠΊΠ°Ρ ΠΊΡΠ»ΡΡΡΡΠ°Β» Ρ ΡΡΡΠ΄Π΅Π½ΡΠΎΠ²-ΠΌΠ΅Π΄ΠΈΠΊΠΎΠ² ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠ»ΠΎΠΆΠ½ΠΎ ΡΠ΅ΡΠ°Π΅ΠΌΠΎΠΉ Π·Π°Π΄Π°ΡΠ΅ΠΉ. ΠΠΎΠΌΠΏΠ»Π΅ΠΊΡ ΠΠ’Π ΠΊΠ°ΠΊ ΠΎΡΠ΅Π½ΠΎΡΠ½ΠΎΠ΅ ΡΡΠ΅Π΄ΡΡΠ²ΠΎ ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΡΠ΅Ρ ΡΡΠ΅Π±ΠΎΠ²Π°Π½ΠΈΡΠΌ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠ³ΠΎ ΠΏΠ΅Π΄Π°Π³ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΎΡΠ΅Π½ΠΈΠ²Π°Π½ΠΈΡ ΠΈ ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠ½ΠΈΠ²Π΅ΡΡΠ°Π»ΡΠ½ΡΠΌ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΠΌ ΠΎΡΠ΅Π½ΠΎΡΠ½ΡΠΌ ΡΡΠ΅Π΄ΡΡΠ²ΠΎΠΌ ΡΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½Π½ΠΎΡΡΠΈ ΠΊΠΎΠΌΠΏΠ΅ΡΠ΅Π½ΡΠΈΠΉ. ΠΠ½Π°Π»ΠΈΠ· ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ², ΠΏΠΎΠΊΠ°Π·Π°Π½Π½ΡΡ
ΡΡΡΠ΄Π΅Π½ΡΠ°ΠΌΠΈ ΠΏΡΠΈ Π²ΡΠΏΠΎΠ»Π½Π΅Π½ΠΈΠΈ ΠΎΡΠ΄Π΅Π»ΡΠ½ΡΡ
Π²ΠΈΠ΄ΠΎΠ² ΠΈΡΠΏΡΡΠ°Π½ΠΈΠΉ, ΡΠ²ΠΈΠ΄Π΅ΡΠ΅Π»ΡΡΡΠ²ΡΠ΅Ρ ΠΎ ΡΡΠ°Π²Π½ΠΈΡΠ΅Π»ΡΠ½ΠΎ ΡΠ»Π°Π±ΠΎΠΉ ΠΏΠΎΠ΄Π³ΠΎΡΠΎΠ²Π»Π΅Π½Π½ΠΎΡΡΠΈ ΠΊ ΡΠ΄Π°ΡΠ΅ Π½ΠΎΡΠΌ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ° ΠΠ’Π. ΠΠ»Ρ ΡΠΎΠ·Π΄Π°Π½ΠΈΡ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ Π±Π»Π°Π³ΠΎΠΏΡΠΈΡΡΠ½ΡΡ
ΡΡΠ»ΠΎΠ²ΠΈΠΉ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΊΠΎΠΌΠΏΠ΅ΡΠ΅Π½ΡΠΈΠΉ ΠΏΠΎ Π΄ΠΈΡΡΠΈΠΏΠ»ΠΈΠ½Π΅ Β«Π€ΠΈΠ·ΠΈΡΠ΅ΡΠΊΠ°Ρ ΠΊΡΠ»ΡΡΡΡΠ°Β» ΠΏΡΠΈ ΠΎΡΠ²ΠΎΠ΅Π½ΠΈΠΈ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°ΡΠ΅Π»ΡΠ½ΠΎΠΉ ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΡ Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎ Π²ΠΈΠ΄Ρ ΠΈΡΠΏΡΡΠ°Π½ΠΈΠΉ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ° ΠΠ’Π Π²ΠΊΠ»ΡΡΠΈΡΡ Π² ΡΠΈΡΠ»ΠΎ Π·Π°ΡΠ΅ΡΠ½ΡΡ
ΡΡΠ΅Π±ΠΎΠ²Π°Π½ΠΈΠΉ ΠΈ ΠΎΡΠ΅Π½ΠΈΠ²Π°ΡΡ ΠΈΡ
Π² ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΠΈΠΈ Ρ Π±Π°Π»Π»ΡΠ½ΠΎ-ΡΠ΅ΠΉΡΠΈΠ½Π³ΠΎΠ²ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΠΎΠΉ
Comparison of quality of life in patients with primary postoperative and autoimmune hypothyreosis
Background. Achieving a high level of quality of life is one of the priorities in the treatment of chronic diseases. Focusing on the quality of life, it is possible to optimally adjust the treatment plan for patients, influencing the link that suffers most in this pathology. Hypothyroidism is mainly formed as a result of surgery on the thyroid gland, or autoimmune thyroiditis, and at the same time is one of the most common endocrine diseases, is of great social importance due to the potentially adverse effect on most organs and systems, resulting in a decrease in quality of life.The aim. To analyze the impact of primary hypothyroidism (postoperative hypothyroidism and autoimmune thyroiditis) on the quality of life of patients.Materials and methods. During the study, a clinical, laboratory and psychological study of 78 women with uncompensated primary hypothyroidism was carried out: 40 women aged 32β76 years with postoperative hypothyroidism (main group) and 38 women aged 36β60 years with autoimmune thyroiditis (comparison group). The quality of life was judged by the indicators of the MOS SF-36 questionnaire.Conclusion. In the examined patients with primary hypothyroidism, an association between an increase in TSH levels and a decrease in all indicators of the quality of life was revealed. First, indicators of physical functioning, general health, role and emotional functioning worsened. The dependence of indicators on the MOS SF-36 scales with the age of patients, the duration of hypothyroidism, and the level of TSH was revealed. The quality of life in patients with postoperative hypothyroidism was significantly reduced compared to patients who had hypothyroidism due to autoimmune thyroiditis
The use of {99m}Tc-Al[2]O[3] for detection of sentinel lymph nodes in cervical cancer patients
The purpose of the study was to evaluate the feasibility of using {99m}Tc-Al[2]O[3]- based radiopharmaceutical, a novel molecular imaging agent for sentinel lymph node detection in patients with invasive cervical cancer. The study included 23 cervical cancer patients (TlaNxMx- T[2]bNxMx) treated at the Tomsk Cancer Research Institute. At 18 hours before surgery, 80 MBq of the {99m}Tc-Al[2]O[3] were injected peritumorally, followed by single-photon emission computed tomography (SPECT) of the pelvis and intraoperative SLN identification. Twenty-seven SLNs were detected by SPECT, and 34 SLNs were identified by intraoperative gamma probe. The total number of identified SLNs per patient ranged from 1 to 3(the mean number of SLNs was 1.4 per patient). The most common site for SLN detection was the external iliac region (57.2%), followed by the internal iliac, obturator, presacral and retrosacral regions (they amounted to 14%, respectively),and the parametrial region (1%). Sensitivity in detecting SLNs was 100% for intraoperative SLN identification and 79% for SPECT image
ΠΠ΅Π»ΡΠΌΠΈΠ½ΡΠΎΠ·ΠΎΠΎΠ½ΠΎΠ·Ρ Π΄ΠΈΠΊΠΈΡ Ρ ΠΈΡΠ½ΡΡ ΠΌΠ»Π΅ΠΊΠΎΠΏΠΈΡΠ°ΡΡΠΈΡ Π² ΠΡΠΈΠΌΠΎΡΡΠΊΠΎΠΌ ΠΊΡΠ°Π΅ ΠΠ°Π»ΡΠ½Π΅Π³ΠΎ ΠΠΎΡΡΠΎΠΊΠ° Π Π€
The purpose of the research is to examine the helminthological status of wild carnivore mammals inhabiting the territory of the Primorsky Krai and to give an epidemiological assessment of their role in maintaining the natural foci of zoonotic infections.Materials and methods. Feces of carnivores were collected in natural habitats of wild animals. Species of animals were identified by the characteristic features of feces and animal tracks. The shape, size, texture and composition of feces were analyzed. The samples were placed in containers with 5% formalin. A part of the material was stored in native form at -12 ΒΊΠ‘. Muscle tissue samples were obtained from animal carcasses. Feces were examined by flotation techniques with a solution of zinc sulfate, the formalin-ethyl acetate sedimentation technique and using an ammonium nitrate solution. After the study, the samples were disinfected by autoclaving at a pressure of 1.5 atm for 2 hours. Muscle tissue samples were examined by digesting in artificial gastric juice using the Gastros device. The species of Trichinella sp. larvae isolated from the positive samples were identified using the nucleotide sequences. In total, 444 feces samples from 13 species of wild carnivore mammals and 449 muscle tissue samples from 13 species were examined.Results and discussion. Wild carnivore mammals inhabiting the territory of the Russian Far East are often infected with various species of helminths localized in the intestine and tissues, which are causative agents of dangerous parasitic zoonoses. A total of 9 species of helminthes in the Siberian tiger (Panthera tigris altaica), 3 species in the Amur leopard (P. pardus orientalis), 2 species in the Eurasian lynx (Lynx lynx), 4 species in the leopard cat (Prionailurus bengalensis), 5 species in the sable (Martes zibellina), 2 species in the yellow-throated marten (M. flavigula), 5 species in the Siberian weasel (Mustela sibirica), 1 species in the American mink (Neovison vison), 2 species in the Asian badger (Meles leucurus), 8 species in the red fox (Vulpes vulpes), 2 species in the raccoon dog (Nyctereutes procyonoides), and 9 species in the brown bear and Asiatic black bear (Ursus arctos and U. thibetanus) were identified at studying of 444 feces samples of wild carnivore mammals in the Primorsky Krai. Among the detected helminths were highly pathogenic for humans: Toxocara cati, Paragonimus westermani and nematodes of the family Capillariidae. Trichinella sp. larvae were detected in 96 samples in the study of 449 samples of muscle tissue from wild carnivore mammals. The above types of helminths are of zoonotic nature. The pathogenic role of accidental infection with helminth species Baylisascaris transfuga has not yet been revealed in humans, that makes this type of bear ascaride potentially dangerous for humans. The studies have shown the widespread prevalence of helminth zoonoses in the Primorsky Krai. These data will help to organize properly the work of people whose jobs involve contact with wild animals.Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ β ΠΈΠ·ΡΡΠΈΡΡ Π³Π΅Π»ΡΠΌΠΈΠ½ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΡΠ°ΡΡΡ Π΄ΠΈΠΊΠΈΡ
Ρ
ΠΈΡΠ½ΡΡ
ΠΌΠ»Π΅ΠΊΠΎΠΏΠΈΡΠ°ΡΡΠΈΡ
, ΠΎΠ±ΠΈΡΠ°ΡΡΠΈΡ
Π½Π° ΡΠ΅ΡΡΠΈΡΠΎΡΠΈΠΈ ΠΡΠΈΠΌΠΎΡΡΠΊΠΎΠ³ΠΎ ΠΊΡΠ°Ρ, ΠΈ Π΄Π°ΡΡ ΡΠΏΠΈΠ΄Π΅ΠΌΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΡΡ ΠΎΡΠ΅Π½ΠΊΡ ΠΈΡ
ΡΠΎΠ»ΠΈ Π² ΠΏΠΎΠ΄Π΄Π΅ΡΠΆΠ°Π½ΠΈΠΈ ΠΏΡΠΈΡΠΎΠ΄Π½ΡΡ
ΠΎΡΠ°Π³ΠΎΠ² Π·ΠΎΠΎΠ½ΠΎΠ·Π½ΡΡ
ΠΈΠ½Π²Π°Π·ΠΈΠΉ.ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. Π€Π΅ΠΊΠ°Π»ΠΈΠΈ Ρ
ΠΈΡΠ½ΡΡ
ΠΌΠ»Π΅ΠΊΠΎΠΏΠΈΡΠ°ΡΡΠΈΡ
ΡΠΎΠ±ΠΈΡΠ°Π»ΠΈ Π² Π΅ΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ
Π±ΠΈΠΎΡΠΎΠΏΠ°Ρ
Π΄ΠΈΠΊΠΈΡ
ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
. ΠΠΈΠ΄ΠΎΠ²ΡΡ ΠΏΡΠΈΠ½Π°Π΄Π»Π΅ΠΆΠ½ΠΎΡΡΡ ΡΠ΅ΠΊΠ°Π»ΠΈΠΉ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ»ΠΈ ΠΏΠΎ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠ½ΡΠΌ Π²ΠΈΠ΄ΠΎΠ²ΡΠΌ ΠΏΡΠΈΠ·Π½Π°ΠΊΠ°ΠΌ ΠΈ ΡΠ»Π΅Π΄Π°ΠΌ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
. ΠΠ½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π»ΠΈ ΡΠΎΡΠΌΡ, ΡΠ°Π·ΠΌΠ΅Ρ, ΠΊΠΎΠ½ΡΠΈΡΡΠ΅Π½ΡΠΈΡ ΠΈ ΡΠΎΡΡΠ°Π² ΡΠ΅ΠΊΠ°Π»ΠΈΠΉ. ΠΡΠΎΠ±Ρ ΠΏΠΎΠΌΠ΅ΡΠ°Π»ΠΈ Π² ΠΊΠΎΠ½ΡΠ΅ΠΉΠ½Π΅ΡΡ Ρ 5%-Π½ΡΠΌ ΡΠΎΡΠΌΠ°Π»ΠΈΠ½ΠΎΠΌ. Π§Π°ΡΡΡ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Π° Ρ
ΡΠ°Π½ΠΈΠ»ΠΈ Π² Π½Π°ΡΠΈΠ²Π½ΠΎΠΌ Π²ΠΈΠ΄Π΅ ΠΏΡΠΈ β12 ΒΊΠ‘. ΠΠ±ΡΠ°Π·ΡΡ ΠΌΡΡΠ΅ΡΠ½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ ΠΏΠΎΠ»ΡΡΠ°Π»ΠΈ ΠΎΡ ΡΡΡΠΏΠΎΠ² ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
. Π€Π΅ΠΊΠ°Π»ΠΈΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π»ΠΈ ΡΠ»ΠΎΡΠ°ΡΠΈΠΎΠ½Π½ΡΠΌ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ Ρ ΡΠ°ΡΡΠ²ΠΎΡΠΎΠΌ ΡΡΠ»ΡΡΠ°ΡΠ° ΡΠΈΠ½ΠΊΠ°, ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΡΡΠΈΠ»Π°ΡΠ΅ΡΠ°Ρ-ΡΠΎΡΠΌΠ°Π»ΠΈΠ½ΠΎΠ²ΠΎΠ³ΠΎ ΠΎΡΠ°ΠΆΠ΄Π΅Π½ΠΈΡ ΠΈ Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΡΠ°ΡΡΠ²ΠΎΡΠ° Π°ΠΌΠΌΠΈΠ°ΡΠ½ΠΎΠΉ ΡΠ΅Π»ΠΈΡΡΡ. ΠΠΎΡΠ»Π΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΎΠ±ΡΠ°Π·ΡΡ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Π° ΠΎΠ±Π΅Π·Π·Π°ΡΠ°ΠΆΠΈΠ²Π°Π»ΠΈ Π°Π²ΡΠΎΠΊΠ»Π°Π²ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ 2 Ρ ΠΏΡΠΈ Π΄Π°Π²Π»Π΅Π½ΠΈΠΈ 1,5 Π°ΡΠΌ. ΠΠ±ΡΠ°Π·ΡΡ ΠΌΡΡΠ΅ΡΠ½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π»ΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΏΠ΅ΡΠ΅Π²Π°ΡΠΈΠ²Π°Π½ΠΈΡ ΠΏΡΠΎΠ± Π² ΠΈΡΠΊΡΡΡΡΠ²Π΅Π½Π½ΠΎΠΌ ΠΆΠ΅Π»ΡΠ΄ΠΎΡΠ½ΠΎΠΌ ΡΠΎΠΊΠ΅ Ρ ΠΏΠΎΠΌΠΎΡΡΡ Π°ΠΏΠΏΠ°ΡΠ°ΡΠ° Gastros. ΠΠΈΠ΄ Π»ΠΈΡΠΈΠ½ΠΎΠΊ Trichinella sp., Π²ΡΠ΄Π΅Π»Π΅Π½Π½ΡΡ
ΠΈΠ· ΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΡΡ
ΠΏΡΠΎΠ±, ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ»ΠΈ Π½Π° ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠΈ Π½ΡΠΊΠ»Π΅ΠΎΡΠΈΠ΄Π½ΡΡ
ΠΏΠΎΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΠ½ΠΎΡΡΠ΅ΠΉ. ΠΡΠ΅Π³ΠΎ ΠΏΡΠΎΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΎ 444 ΠΏΡΠΎΠ±Ρ ΡΠ΅ΠΊΠ°Π»ΠΈΠΉ 13 Π²ΠΈΠ΄ΠΎΠ² Π΄ΠΈΠΊΠΈΡ
Ρ
ΠΈΡΠ½ΡΡ
ΠΌΠ»Π΅ΠΊΠΎΠΏΠΈΡΠ°ΡΡΠΈΡ
ΠΈ 449 ΠΏΡΠΎΠ± ΠΌΡΡΠ΅ΡΠ½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ 13 Π²ΠΈΠ΄ΠΎΠ².Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈ ΠΎΠ±ΡΡΠΆΠ΄Π΅Π½ΠΈΠ΅. ΠΠΈΠΊΠΈΠ΅ Ρ
ΠΈΡΠ½ΡΠ΅ ΠΌΠ»Π΅ΠΊΠΎΠΏΠΈΡΠ°ΡΡΠΈΠ΅, ΠΎΠ±ΠΈΡΠ°ΡΡΠΈΠ΅ Π½Π° ΡΠ΅ΡΡΠΈΡΠΎΡΠΈΠΈ ΠΠ°Π»ΡΠ½Π΅Π³ΠΎ ΠΠΎΡΡΠΎΠΊΠ° Π ΠΎΡΡΠΈΠΈ, ΡΠ°ΡΡΠΎ Π±ΡΠ²Π°ΡΡ Π·Π°ΡΠ°ΠΆΠ΅Π½Ρ ΡΠ°Π·Π»ΠΈΡΠ½ΡΠΌΠΈ Π²ΠΈΠ΄Π°ΠΌΠΈ Π³Π΅Π»ΡΠΌΠΈΠ½ΡΠΎΠ² ΠΊΠΈΡΠ΅ΡΠ½ΠΎΠΉ ΠΈ ΡΠΊΠ°Π½Π΅Π²ΠΎΠΉ Π»ΠΎΠΊΠ°Π»ΠΈΠ·Π°ΡΠΈΠΈ, ΡΠ²Π»ΡΡΡΠΈΠΌΠΈΡΡ Π²ΠΎΠ·Π±ΡΠ΄ΠΈΡΠ΅Π»ΡΠΌΠΈ ΠΎΠΏΠ°ΡΠ½ΡΡ
Π°Π½ΡΡΠΎΠΏΠΎΠ·ΠΎΠΎΠ½ΠΎΠ·ΠΎΠ². ΠΡΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΈ 444 ΠΏΡΠΎΠ± ΡΠ΅ΠΊΠ°Π»ΠΈΠΉ Π΄ΠΈΠΊΠΈΡ
Ρ
ΠΈΡΠ½ΡΡ
ΠΌΠ»Π΅ΠΊΠΎΠΏΠΈΡΠ°ΡΡΠΈΡ
Π² ΠΡΠΈΠΌΠΎΡΡΠΊΠΎΠΌ ΠΊΡΠ°Π΅ Ρ Π°ΠΌΡΡΡΠΊΠΎΠ³ΠΎ ΡΠΈΠ³ΡΠ° (Panthera tigris altaica) Π²ΡΡΠ²Π»Π΅Π½ΠΎ 9 Π²ΠΈΠ΄ΠΎΠ² Π³Π΅Π»ΡΠΌΠΈΠ½ΡΠΎΠ², Ρ Π°ΠΌΡΡΡΠΊΠΎΠ³ΠΎ Π»Π΅ΠΎΠΏΠ°ΡΠ΄Π° (P. Pardus orientalis) β 3, Ρ Π΅Π²ΡΠ°Π·ΠΈΠΉΡΠΊΠΎΠΉ ΡΡΡΠΈ (Lynx lynx) β 2, Ρ Π±Π΅Π½Π³Π°Π»ΡΡΠΊΠΎΠ³ΠΎ ΠΊΠΎΡΠ° (Prionailurus bengalensis) β 4, Ρ ΡΠΎΠ±ΠΎΠ»Ρ (Martes zibellina) β 5, Ρ Ρ
Π°ΡΠ·Ρ (M. flavigula) β 2, Ρ ΡΠΈΠ±ΠΈΡΡΠΊΠΎΠ³ΠΎ ΠΊΠΎΠ»ΠΎΠ½ΠΊΠ° (Mustela sibirica) β 5, Ρ Π°ΠΌΠ΅ΡΠΈΠΊΠ°Π½ΡΠΊΠΎΠΉ Π½ΠΎΡΠΊΠΈ (Neovison vison) β 1, Ρ Π°Π·ΠΈΠ°ΡΡΠΊΠΎΠ³ΠΎ Π±Π°ΡΡΡΠΊΠ° (Meles leucurus) β 2, Ρ Π»ΠΈΡΠΈΡΡ (Vulpes vulpes) β 8, Ρ Π΅Π½ΠΎΡΠΎΠ²ΠΈΠ΄Π½ΠΎΠΉ ΡΠΎΠ±Π°ΠΊΠΈ (Nyctereutes procyonoides) β 2 ΠΈ Ρ Π±ΡΡΠΎΠ³ΠΎ ΠΈ Π³ΠΈΠΌΠ°Π»Π°ΠΉΡΠΊΠΎΠ³ΠΎ ΠΌΠ΅Π΄Π²Π΅Π΄Π΅ΠΉ (Ursus arctos, U. thibetanus) β 9 Π²ΠΈΠ΄ΠΎΠ². Π‘ΡΠ΅Π΄ΠΈ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½Π½ΡΡ
Π³Π΅Π»ΡΠΌΠΈΠ½ΡΠΎΠ² Π±ΡΠ»ΠΈ Π²ΡΡΠΎΠΊΠΎ ΠΏΠ°ΡΠΎΠ³Π΅Π½Π½ΡΠ΅ Π΄Π»Ρ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°: Toxocara cati, Paragonimus westermani ΠΈ Π½Π΅ΠΌΠ°ΡΠΎΠ΄Ρ ΡΠ΅ΠΌ. Π‘aΡillariidae. ΠΡΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΈ 449 ΠΏΡΠΎΠ± ΠΌΡΡΠ΅ΡΠ½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ Π΄ΠΈΠΊΠΈΡ
Ρ
ΠΈΡΠ½ΡΡ
ΠΌΠ»Π΅ΠΊΠΎΠΏΠΈΡΠ°ΡΡΠΈΡ
Π² 96 Π²ΡΡΠ²Π»Π΅Π½Ρ Π»ΠΈΡΠΈΠ½ΠΊΠΈ Trichinella sp. ΠΡΡΠ΅ΠΏΠ΅ΡΠ΅ΡΠΈΡΠ»Π΅Π½Π½ΡΠ΅ Π²ΠΈΠ΄Ρ Π³Π΅Π»ΡΠΌΠΈΠ½ΡΠΎΠ² ΠΈΠΌΠ΅ΡΡ Π·ΠΎΠΎΠ½ΠΎΠ·Π½ΡΡ ΠΏΡΠΈΡΠΎΠ΄Ρ. ΠΠ°ΡΠΎΠ³Π΅Π½Π½Π°Ρ ΡΠΎΠ»Ρ ΠΏΡΠΈ ΡΠ»ΡΡΠ°ΠΉΠ½ΠΎΠΌ Π·Π°ΡΠ°ΠΆΠ΅Π½ΠΈΠΈ Π³Π΅Π»ΡΠΌΠΈΠ½ΡΠ°ΠΌΠΈ Π²ΠΈΠ΄Π° Baylisascaris transfuga Π½Π° ΡΠ΅Π³ΠΎΠ΄Π½ΡΡΠ½ΠΈΠΉ Π΄Π΅Π½Ρ Ρ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° Π½Π΅ ΠΈΠ·ΡΡΠ΅Π½Π°, ΡΡΠΎ Π΄Π΅Π»Π°Π΅Ρ ΡΡΠΎΡ Π²ΠΈΠ΄ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΠΎ ΠΎΠΏΠ°ΡΠ½ΡΠΌ Π΄Π»Ρ Π»ΡΠ΄Π΅ΠΉ. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠ²ΠΈΠ΄Π΅ΡΠ΅Π»ΡΡΡΠ²ΡΡΡ ΠΎ ΡΠΈΡΠΎΠΊΠΎΠΌ ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½ΠΈΠΈ Π³Π΅Π»ΡΠΌΠΈΠ½ΡΠΎΠ·ΠΎΠΎΠ½ΠΎΠ·ΠΎΠ² Π½Π° ΡΠ΅ΡΡΠΈΡΠΎΡΠΈΠΈ ΠΡΠΈΠΌΠΎΡΡΠΊΠΎΠ³ΠΎ ΠΊΡΠ°Ρ. ΠΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΏΠΎΠΌΠΎΠ³ΡΡ ΠΏΡΠ°Π²ΠΈΠ»ΡΠ½ΠΎ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΎΠ²Π°ΡΡ ΡΠ°Π±ΠΎΡΡ Π»ΡΠ΄Π΅ΠΉ, ΡΡΡ ΠΏΡΠΎΡΠ΅ΡΡΠΈΠΎΠ½Π°Π»ΡΠ½Π°Ρ Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΡ ΠΏΡΠ΅Π΄ΡΡΠΌΠ°ΡΡΠΈΠ²Π°Π΅Ρ ΠΊΠΎΠ½ΡΠ°ΠΊΡΡ Ρ Π΄ΠΈΠΊΠΈΠΌΠΈ ΠΆΠΈΠ²ΠΎΡΠ½ΡΠΌΠΈ
ΠΠ‘Π’Π ΠΠ― Π’ΠΠΠ‘ΠΠ§ΠΠΠ‘Π’Π¬ Π‘Π£ΠΠ ΠΠΠΠΠΠΠ£ΠΠ―Π ΠΠ«Π₯ ΠΠΠΠΠΠΠΠ‘ΠΠ Π€ΠΠΠΠΠΠΠΠΠΠΠ, ΠΠΠΠ£Π§ΠΠΠΠ«Π₯ ΠΠ ΠΠΠ₯ΠΠΠΠ₯ΠΠΠΠ§ΠΠ‘ΠΠΠ Π’ΠΠ₯ΠΠΠΠΠΠΠ Π‘ ΠΠ‘ΠΠΠΠ¬ΠΠΠΠΠΠΠΠ ΠΠΠ ΠΠ‘ΠΠΠ ΠΠΠ‘Π’ΠΠΠΠ DRUG DELIVERY SYSTEM
Objective of research: studying of acute toxicity of supramolecular complexes of Fenbendazole developed using chemical mechanical technology in comparison with the substance of preparation injected to the stomach of white mice and rats. Materials and methods: The research of parameters of acute toxicity of the supramolecular complexes of Fenbendazole was conducted according to Β«Guidelines for experimental (pre-clinical) studies of new pharmaceutical compoundsΒ», and other rules. Preparations were injected to the stomach of white rats and mice of both gender with the body mass 160β180 and 18β20 g. at a single dose 7 000, 10 000, 15 000 and 20 000 mg/ kg, respectively. Each dose was investigated on 6 white rats and 10 white mice. Within 14 days we observed the general health status and behavior of animals, symptoms of intoxication and eventual death. We also conducted postmortem examinations of the fallen animals. The parameters of acute toxicity were determined by the method of Litchfield J. and Wilcoxon F. (M.D. Belenβky, 1963). Results and discussion: It was not possible to detect LD50 in supramolecular complex of Fenbendazole and the base Β drug Fenbendazole due to the low toxicity. The maximum endurable dose of supramolecular complex no. 2 was 10 000 mg/kg, LD50 -value in supramolecular complex of Fenbendazole no. 2 at injection to the stomach of white mice and rats was 20 000 mg/kg.Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ β ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΠΎΡΡΡΠΎΠΉ ΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡΠΈ ΡΡΠΏΡΠ°ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΡ
ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠΎΠ² ΡΠ΅Π½Π±Π΅Π½Π΄Π°Π·ΠΎΠ»Π°, ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ
ΠΏΠΎ ΠΌΠ΅Ρ
Π°Π½ΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΈ Π² ΡΡΠ°Π²Π½Π΅Π½ΠΈΠΈ Ρ ΡΡΠ±ΡΡΠ°Π½ΡΠΈΠ΅ΠΉ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ° ΠΏΡΠΈ Π²Π²Π΅Π΄Π΅Π½ΠΈΠΈ Π² ΠΆΠ΅Π»ΡΠ΄ΠΎΠΊ Π±Π΅Π»ΡΠΌ ΠΌΡΡΠ°ΠΌ ΠΈ ΠΊΡΡΡΠ°ΠΌ. ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΠΎΠ² ΠΎΡΡΡΠΎΠΉ ΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡΠΈ ΡΡΠΏΡΠ°ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΡ
ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠΎΠ² Ρ ΡΠ΅Π½Π±Π΅Π½Π΄Π°Π·ΠΎΠ»ΠΎΠΌ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ ΡΠΎΠ³Π»Π°ΡΠ½ΠΎ Β«Π ΡΠΊΠΎΠ²ΠΎΠ΄ΡΡΠ²Ρ ΠΏΠΎ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎΠΌΡ (Π΄ΠΎΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΌΡ) ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ Π½ΠΎΠ²ΡΡ
ΡΠ°ΡΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
Π²Π΅ΡΠ΅ΡΡΠ²Β» ΠΈ Π΄ΡΡΠ³ΠΈΡ
ΠΏΡΠ°Π²ΠΈΠ». ΠΡΠ΅ΠΏΠ°ΡΠ°ΡΡ Π²Π²ΠΎΠ΄ΠΈΠ»ΠΈ ΠΏΠΎΠ΄ΠΎΠΏΡΡΠ½ΡΠΌ Π±Π΅Π»ΡΠΌ ΠΊΡΡΡΠ°ΠΌ ΠΈ ΠΌΡΡΠ°ΠΌ ΠΎΠ±ΠΎΠ΅Π³ΠΎ ΠΏΠΎΠ»Π° ΠΌΠ°ΡΡΠΎΠΉ ΡΠ΅Π»Π° 160β180 ΠΈ 18β20 Π³ ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²Π΅Π½Π½ΠΎ ΠΎΠ΄Π½ΠΎΠΊΡΠ°ΡΠ½ΠΎ Π² ΠΆΠ΅Π»ΡΠ΄ΠΎΠΊ Π² Π΄ΠΎΠ·Π°Ρ
7 000, 10 000, 15 000 ΠΈ 20 000 ΠΌΠ³/ΠΊΠ³ ΠΏΠΎ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΡ. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΊΠ°ΠΆΠ΄ΠΎΠΉ Π΄ΠΎΠ·Ρ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ Π½Π° 6 Π±Π΅Π»ΡΡ
ΠΊΡΡΡΠ°Ρ
ΠΈ 10 Π±Π΅Π»ΡΡ
ΠΌΡΡΠ°Ρ
. Π ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ 14 ΡΡΡ Π½Π°Π±Π»ΡΠ΄Π°Π»ΠΈ Π·Π° ΠΎΠ±ΡΠΈΠΌ ΡΠΎΡΡΠΎΡΠ½ΠΈΠ΅ΠΌ ΠΈ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ΠΌ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
, ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΠ΅ΠΌ ΡΠΈΠΌΠΏΡΠΎΠΌΠΎΠ² ΠΈΠ½ΡΠΎΠΊΡΠΈΠΊΠ°ΡΠΈΠΈ ΠΈ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΠΉ Π³ΠΈΠ±Π΅Π»ΡΡ. ΠΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΎΠ°Π½Π°ΡΠΎΠΌΠΈΡΠ΅ΡΠΊΠΎΠ΅ Π²ΡΠΊΡΡΡΠΈΠ΅ ΠΏΠ°Π²ΡΠΈΡ
ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
. ΠΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ ΠΎΡΡΡΠΎΠΉ ΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡΠΈ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ»ΠΈ ΠΏΠΎ ΠΠΈΡΡΡΠΈΠ»Π΄Ρ ΠΈ Π£ΠΈΠ»ΠΊΠΎΠΊΡΠΎΠ½Ρ (Π. Π. ΠΠ΅Π»Π΅Π½ΡΠΊΠΈΠΉ, 1963). Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈ ΠΎΠ±ΡΡΠΆΠ΄Π΅Π½ΠΈΠ΅. ΠΠ50 ΡΡΠΏΡΠ°ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎΠ³ΠΎ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ° ΡΠ΅Π½Π±Π΅Π½Π΄Π°Π·ΠΎΠ»Π° ΠΈ Π±Π°Π·ΠΎΠ²ΠΎΠ³ΠΎ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ° β ΡΠ΅Π½Π±Π΅Π½Π΄Π°Π·ΠΎΠ»Π° ΡΡΡΠ°Π½ΠΎΠ²ΠΈΡΡ Π½Π΅ ΡΠ΄Π°Π»ΠΎΡΡ ΠΈΠ·-Π·Π° Π½ΠΈΠ·ΠΊΠΎΠΉ ΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡΠΈ. ΠΠ°ΠΊΡΠΈΠΌΠ°Π»ΡΠ½ΠΎ ΠΏΠ΅ΡΠ΅Π½ΠΎΡΠΈΠΌΠ°Ρ Π΄ΠΎΠ·Π° ΡΡΠΏΡΠ°ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎΠ³ΠΎ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ° β 2 ΡΠΎΡΡΠ°Π²ΠΈΠ»Π° 10 000 ΠΌΠ³/ ΠΊΠ³, ΠΠ50 ΡΡΠΏΡΠ°ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎΠ³ΠΎ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ° Ρ ΡΠ΅Π½Π±Π΅Π½Π΄Π°Π·ΠΎΠ»ΠΎΠΌ β 2 ΠΏΡΠΈ Π²Π²Π΅Π΄Π΅Π½ΠΈΠΈ Π² ΠΆΠ΅Π»ΡΠ΄ΠΎΠΊ Π±Π΅Π»ΡΠΌ ΠΌΡΡΠ°ΠΌ ΠΈ ΠΊΡΡΡΠ°ΠΌ β 20 000 ΠΌΠ³/ΠΊΠ³
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