243 research outputs found

    Behavioral effects observed in human newborns during exposure to naturally occurring odors

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    http://www.ester.ee/record=b1195000~S1*es

    From microRNA target validation to therapy : lessons learned from studies on BDNF

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    During the past decade, the identification of microRNA (miR) targets has become common laboratory practice, and various strategies are now used to detect interactions between miRs and their mRNA targets. However, the current lack of a standardized identification process often leads to incomplete and/or conflicting results. Here, we review the problems most commonly encountered when verifying miR-mRNA interactions, and we propose a workflow for future studies. To illustrate the challenges faced when validating a miR target, we discuss studies in which the regulation of brain-derived neurotrophic factor by miRs was investigated, and we highlight several controversies that emerged from these studies. Finally, we discuss the therapeutic use of miR inhibitors, and we discuss several questions that should be addressed before proceeding to preclinical testing.Peer reviewe

    Esimese kooliastme võõrkeeleõpetajate hinnangud lõimimisvõtete olulisuse ja kasutamise kohta

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    http://tartu.ester.ee/record=b2559046~S6*es

    Enneaegse sünnituse ja enneaegse vastsündinu perinataalperioodi ravijuhend

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    Eesti Arst 2017; 96(7):422–43

    A Coalgebraic View of Infinite Trees and Iteration

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    AbstractThe algebra of infinite trees is, as proved by C. Elgot, completely iterative, i.e., all ideal recursive equations are uniquely solvable. This is proved here to be a general coalgebraic phenomenon: let H be an endofunctor such that for every object X a final coalgebra, TX, of H(_) + X exists. Then TX is an object-part of a monad which is completely iterative. Moreover, a similar contruction of a “completely iterative monoid” is possible in every monoidal category satisfying mild side conditions

    Väga enneaegsete vastsündinute ravitulem Eestis

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    Artiklis on esitatud ülevaade väga enneaegsete vastsündinute ravitrendidest maailmas ja Eesti Perinatoloogia Seltsi algatusel korraldatud uuringust, millest selgusid selle patsiendirühma ravitulemused Eestis. Aastatel 2007–2008 hinnati internetipõhise “Vastsündinute tervise andmekogu” baasil enneaegseid vastsündinuid ravitakse Eestis aktiivselt. Laste elulemus on kõrge ja varane haigestumine suur. Eesti Arst 2009; 88(Lisa4):12−2
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