6,841 research outputs found
Heavy Quark Production and PDF's Subgroup Report
We present a status report of a variety of projects related to heavy quark
production and parton distributions for the Tevatron Run II.Comment: Latex. 8 pages, 7 eps figures. Contribution to the Physics at Run II
Workshops: QCD and Weak Boson Physic
Tourism income and economic growth in Greece: Empirical evidence from their cyclical components
This paper examines the relationship between the cyclical
components of Greek GDP and international tourism income for
Greece for the period 1976–2004. Using spectral analysis the authors
find that cyclical fluctuations of GDP have a length of about nine
years and that international tourism income has a cycle of about
seven years. The volatility of tourism income is more than eight
times the volatility of the Greek GDP cycle. VAR analysis shows that
the cyclical component of tourism income is significantly influencing
the cyclical component of GDP in Greece. The findings support the
tourism-led economic growth hypothesis and are of particular
interest and importance to policy makers, financial analysts and
investors dealing with the Greek tourism industry
Parton Distributions Working Group
The main focus of this working group was to investigate the different issues
associated with the development of quantitative tools to estimate parton
distribution functions uncertainties. In the conclusion, we introduce a
"Manifesto" that describes an optimal method for reporting data.Comment: Report of the Parton Distributions Working Group of the 'QCD and Weak
Boson Physics workshop in preparation for Run II at the Fermilab Tevatron'.
Co-Conveners: L. de Barbaro, S.A. Keller, S. Kuhlmann, H. Schellman, and
W.-K. Tun
Histone Acetylation-Mediated Regulation of the Hippo Pathway
The Hippo pathway is a signaling cascade recently found to play a key role in tumorigenesis therefore understanding the mechanisms that regulate it should open new opportunities for cancer treatment. Available data indicate that this pathway is controlled by signals from cell-cell junctions however the potential role of nuclear regulation has not yet been described. Here we set out to verify this possibility and define putative mechanism(s) by which it might occur. By using a luciferase reporter of the Hippo pathway, we measured the effects of different nuclear targeting drugs and found that chromatin-modifying agents, and to a lesser extent certain DNA damaging drugs, strongly induced activity of the reporter. This effect was not mediated by upstream core components (i.e. Mst, Lats) of the Hippo pathway, but through enhanced levels of the Hippo transducer TAZ. Investigation of the underlying mechanism led to the finding that cancer cell exposure to histone deacetylase inhibitors induced secretion of growth factors and cytokines, which in turn activate Akt and inhibit the GSK3 beta associated protein degradation complex in drug-affected as well as in their neighboring cells. Consequently, expression of EMT genes, cell migration and resistance to therapy were induced. These processes were suppressed by using pyrvinium, a recently described small molecule activator of the GSK 3 beta associated degradation complex. Overall, these findings shed light on a previously unrecognized phenomenon by which certain anti-cancer agents may paradoxically promote tumor progression by facilitating stabilization of the Hippo transducer TAZ and inducing cancer cell migration and resistance to therapy. Pharmacological targeting of the GSK3 beta associated degradation complex may thus represent a unique approach to treat cancer. © 2013 Basu et al
Evidence for Parton kT Effects in High pT Particle Production
Inclusive pizero and direct-photon cross sections in the kinematic range 3.5
< pT < 12 GeV/c with central rapidities are presented for 530 and 800 GeV/c
proton beams and a 515 GeV/c pi- beam incident on beryllium targets. Current
Next-to-Leading-Order perturbative QCD calculations fail to adequately describe
the data for conventional choices of scales. Kinematic distributions from these
hard scattering events provide evidence that the interacting partons carry
significant initial-state parton transverse momentum (kT). Incorporating these
kT effects phenomenologically greatly improves the agreement between
calculations and the measured cross sections.Comment: 11 pages including 6 pages of figures with caption
Measurement of direct photon production at Tevatron fixed target energies
Measurements of the production of high transverse momentum direct photons by
a 515 GeV/c piminus beam and 530 and 800 GeV/c proton beams in interactions
with beryllium and hydrogen targets are presented. The data span the kinematic
ranges of 3.5 < p_T < 12 GeV/c in transverse momentum and 1.5 units in
rapidity. The inclusive direct-photon cross sections are compared with
next-to-leading-order perturbative QCD calculations and expectations based on a
phenomenological parton-k_T model.Comment: RevTeX4, 23 pages, 32 figures, submitted to Phys. Rev.
Production of pizero and eta mesons at large transverse momenta in pi-p and pi-Be interactions at 515 GeV/c
We present results on the production of high transverse momentum pizero and
eta mesons in pi-p and pi-Be interactions at 515 GeV/c. The data span the
kinematic ranges 1 < p_T < 11 GeV/c in transverse momentum and -0.75 < y < 0.75
in rapidity. The inclusive pizero cross sections are compared with
next-to-leading order QCD calculations and to expectations based on a
phenomenological parton-k_T model.Comment: RevTeX4, 15 pages, 15 figures, to be submitted to Phys. Rev.
Mathematical and Statistical Techniques for Systems Medicine: The Wnt Signaling Pathway as a Case Study
The last decade has seen an explosion in models that describe phenomena in
systems medicine. Such models are especially useful for studying signaling
pathways, such as the Wnt pathway. In this chapter we use the Wnt pathway to
showcase current mathematical and statistical techniques that enable modelers
to gain insight into (models of) gene regulation, and generate testable
predictions. We introduce a range of modeling frameworks, but focus on ordinary
differential equation (ODE) models since they remain the most widely used
approach in systems biology and medicine and continue to offer great potential.
We present methods for the analysis of a single model, comprising applications
of standard dynamical systems approaches such as nondimensionalization, steady
state, asymptotic and sensitivity analysis, and more recent statistical and
algebraic approaches to compare models with data. We present parameter
estimation and model comparison techniques, focusing on Bayesian analysis and
coplanarity via algebraic geometry. Our intention is that this (non exhaustive)
review may serve as a useful starting point for the analysis of models in
systems medicine.Comment: Submitted to 'Systems Medicine' as a book chapte
New Particles Working Group Report of the Snowmass 2013 Community Summer Study
This report summarizes the work of the Energy Frontier New Physics working
group of the 2013 Community Summer Study (Snowmass)
Direct Measurement of the Top Quark Mass at D0
We determine the top quark mass m_t using t-tbar pairs produced in the D0
detector by \sqrt{s} = 1.8 TeV p-pbar collisions in a 125 pb^-1 exposure at the
Fermilab Tevatron. We make a two constraint fit to m_t in t-tbar -> b W^+bbar
W^- final states with one W boson decaying to q-qbar and the other to e-nu or
mu-nu. Likelihood fits to the data yield m_t(l+jets) = 173.3 +- 5.6 (stat) +-
5.5 (syst) GeV/c^2. When this result is combined with an analysis of events in
which both W bosons decay into leptons, we obtain m_t = 172.1 +- 5.2 (stat) +-
4.9 (syst) GeV/c^2. An alternate analysis, using three constraint fits to fixed
top quark masses, gives m_t(l+jets) = 176.0 +- 7.9 (stat) +- 4.8 (syst)
GeV/C^2, consistent with the above result. Studies of kinematic distributions
of the top quark candidates are also presented.Comment: 43 pages, 53 figures, 33 tables. RevTeX. Submitted to Phys. Rev.
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