Evaluation of the strain-line patterns in a human left ventricle: A simulation study

The aim of this paper is to emphasise the role of the primary strain-line patterns in a human left ventricle (LV) within the complex system that is the heart. In particular, a protocol is proposed for the measurement of the principal strain lines (PSL) in the walls of the LV; this protocol is tested by means of a computational model which resembles a human LV. When the analysis is focused on the epicardial surface, PSL can be used to derive information on the directions of muscle fibres during the entire cardiac cycle, not only the systolic phase. © 2013 Taylor & Francis

The Anti-Gang Initiative in Detroit: An Aggressive Enforcement Approach to Gangs

Over the period of the intervention and operation of the-AGI project, there was a considerable decline in gun crimes in the target precincts, whereas the number of such offenses rose in the comparison precinct. This was particularly the case in the Ninth Precinct, where a statistically significant reduction of gun crimes occurred. Perhaps more importantly, this reduction represented 112 fewer gun crimes, and thus a commensurate fewer number of victims, per month in this precinct. Given the design of this study and available data, these results cannot be directly attributed to the intervention. However, there is a strong indication that these aggressive policing tactics contributed significantly to this meaningful reduction

In-Situ Particle Acceleration in Extragalactic Radio Hot Spots: Observations Meet Expectations

We discuss, in terms of particle acceleration, the results from optical VLT observations of hot spots associated with radio galaxies. On the basis of observational and theoretical grounds, it is shown that: 1. relatively low radio-radio power hot spots are the optimum candidates for being detected at optical waves. This is supported by an unprecedented optical detection rate of 70% out of a sample of low radio power hot spots. 2. the shape of the synchrotron spectrum of hot spots is mainly determined by the strength of the magnetic field in the region. In particular, the break frequency, related to the age of the oldest electrons in the hot spots, is found to increase with decreasing synchrotron power and magnetic field strength. Both observational results are in agreement with an in-situ particle acceleration scenario.Comment: 5 pages, TeX (or Latex, etc), 4 figures, to appear in MNRAS Letter, Updated reference

Exploring the Drugs-Homicide Connection

Although research generally assumes a close relationship between drugs and violence, very little is known about the many different roles drugs can play in criminal events. Drug related as an event classification scheme is relatively common in homicide research, as well as other areas of inquiry, and is usually understood to be an important component in the causal processes of criminal events. Yet such classification schemes often suggest a simple, unidimensional construct. In reality, drug-related crimes are com-plex events. The purpose of this researchwas first to disaggregate the concept of drug-related homicide by providing an event classification scheme that conceptualizes the diverse roles drugs play in drug-related events.Acategorical coding scheme is presented that is similar to that proposed by Goldstein (1995) and later tested by Brownstein and colleagues (Brownstein & Goldstein, 1990; Brownstein, Baxi, Goldstein, & Ryan, 1992) that specifies three distinct types of homicide events. Included among these are (a) events that involved no evidence of illicit drugs associated with the homicide event, (b) those that involved the presence of drugs or drug use at the scene as well as events where either the victim and/or offender were buying or selling drugs (we term this peripherally drug-related homicides), and (c) events where the sale or use of drugswas the motivating feature of the homicide event. In some situations, there may be overlap between categories b and c; however, category c is distinct in that it includes features of motivation. The second purpose was to determine the relative importance of various situational and contextual characteristics of homicide events in understanding different types of drug-related events. Delineating these features will be an important step in filling in the gaps of knowledge about the assumed relationship between drugs and violence

Street Outreach Workers: Best Practices and Lessons Learned

Street outreach workers are an important part of the Senator Charles E. Shannon Jr. Community Safety Initiative (CSI) comprehensive gang and youth violence reduction strategy in Massachusetts1. Street outreach involves the use of individuals to “work the streets,” making contact with youth in neighborhoods with high levels of gang activity. These individuals are generally not employed by the criminal justice system agencies but rather are based in community service organizations or other non- governmental agencies. Street outreach workers provide an important bridge between the community, gang-involved youth, and the agencies (whether social service or law enforcement) that respond to the problems of delinquency and gangs. This guide offers information, guidance, and lessons learned from street outreach programs nationally and within the Massachusetts Shannon CSI communities to help guide existing street outreach programs and support communities considering developing new street outreach programs

Chandra detection of the radio and optical double hot spot of 3C 351

In this letter we report a Chandra X-ray detection of the double northern hot spot of the radio quasar 3C 351. The hot spot has also been observed in the optical with the Hubble Space Telescope (R-band) and with the 3.5m. Telescopio Nazionale Galileo (B-band). The radio-to-optical and X-ray spectra are interpreted as the results of the synchrotron and synchrotron-self-Compton (SSC) mechanisms, respectively, with hot-spot magnetic field strengths ~3 times smaller than the equipartition values. In the framework of shock acceleration theory, we show that the requirement for such a relatively small field strength is in agreement with the fitted synchrotron spectral models and with the sizes of the hot spots. Finally, we show that the combination of a lower magnetic field strength with the high frequencies of the synchrotron cut-off in the fitted synchrotron spectra provides strong evidence for electron acceleration in the hot spots.Comment: 16 pag. + 2 .PS figures (fig.2 color), ApJ Letter in pres

Speech-driven facial animations improve speech-in-noise comprehension of humans

Understanding speech becomes a demanding task when the environment is noisy. Comprehension of speech in noise can be substantially improved by looking at the speaker’s face, and this audiovisual benefit is even more pronounced in people with hearing impairment. Recent advances in AI have allowed to synthesize photorealistic talking faces from a speech recording and a still image of a person’s face in an end-to-end manner. However, it has remained unknown whether such facial animations improve speech-in-noise comprehension. Here we consider facial animations produced by a recently introduced generative adversarial network (GAN), and show that humans cannot distinguish between the synthesized and the natural videos. Importantly, we then show that the end-to-end synthesized videos significantly aid humans in understanding speech in noise, although the natural facial motions yield a yet higher audiovisual benefit. We further find that an audiovisual speech recognizer (AVSR) benefits from the synthesized facial animations as well. Our results suggest that synthesizing facial motions from speech can be used to aid speech comprehension in difficult listening environments

Left atrial trajectory impairment in hypertrophic cardiomyopathy disclosed by geometric morphometrics and parallel transport

The analysis of full Left Atrium (LA) deformation and whole LA deformational trajectory in time has been poorly investigated and, to the best of our knowledge, seldom discussed in patients with Hypertrophic Cardiomyopathy. Therefore, we considered 22 patients with Hypertrophic Cardiomyopathy (HCM) and 46 healthy subjects, investigated them by three-dimensional Speckle Tracking Echocardiography, and studied the derived landmark clouds via Geometric Morphometrics with Parallel Transport. Trajectory shape and trajectory size were different in Controls versus HCM and their classification powers had high AUC (Area Under the Receiving Operator Characteristic Curve) and accuracy. The two trajectories were much different at the transition between LA conduit and booster pump functions. Full shape and deformation analyses with trajectory analysis enabled a straightforward perception of pathophysiological consequences of HCM condition on LA functioning. It might be worthwhile to apply these techniques to look for novel pathophysiological approaches that may better define atrio-ventricular interaction

OLIMPIC : a 12-month study on the criteria driving retreatment with ranibizumab in patients with visual impairment due to myopic choroidal neovascularization

Purpose: To evaluate criteria driving retreatment with ranibizumab in Italian patients with myopic choroidal neovascularization (mCNV). Methods: OLIMPIC was a 12-month, phase IIIb, open-label study. Patients with active mCNV were treated with ranibizumab 0.5 mg according to the European label. The study assessed local criteria in Italy driving retreatment decisions with ranibizumab; and the efficacy, safety, and tolerability of ranibizumab. Results: The mean (standard deviation [SD]) age of treated patients (N = 200) was 61.8 (12.7) years; range 22\u201385 years. The multivariate regression model indicated that presence of active leakage (odds ratio [OR] 95% confidence interval [CI]: 11.30 [1.03\u2013124.14]), presence of intraretinal fluid (OR [95%CI]: 28.21 [1.55\u2013513.73]), and an improvement in best-corrected visual acuity (BCVA) from baseline < 10 letters (OR [95%CI]: 17.60 [1.39\u2013222.75]) were the factors with the greatest effect on retreatment with ranibizumab. The mean (SD) BCVA gain from baseline to month 12 was 8.4 (12.8) letters (P < 0.0001). The mean (SD) number of injections was 2.41 (1.53); range 1\u20139. Ocular and non-ocular adverse events were reported in 41 (20.5%) and 30 (15.0%) patients, respectively. Conclusions: Individualized treatment with ranibizumab was effective in improving BCVA in patients with mCNV over 12 months. Both anatomical and functional variables had significant effects on causing retreatment. There were no new safety findings. Trial registration: www.ClinicalTrials.Gov (NCT No: NCT02034006)