Interleukins As a Marker of Inflammation in Diabetic Foot Syndrome and Type 2 Diabetes Mellitus

Conclusion: According to our results, IL-12 P70, IL-17 and IL-18 can be used as biomarkers for diabetic foot. Further studies arc needed to show the role of IL-12 P70, IL-17 and IL-18 levels as a biomarker in chronic inflammatory diseases

Patients with primary restless legs syndrome have higher prevalence of autonomic dysfunction and irritable bowel syndrome

CONCLUSION The presence of autonomic nervous system impairment in patients with pRLS and the strong link between IBS and pRLS merit further, more extensive investigation

Kan Grupları, Gestasyonel Diyabet için Bir Risk Faktörü Müdür?

Amaç Gestasyonel Diyabetes Mellitus (GDM) sıklığı giderek artan ve perinatal komplikasyonlar ile ilişkisi gösterilmiş klinik durumdur. Bu durumun kan grupları ile arasındakiilişki kesin olarak belli değildir. Biz bu çalışmada kendi coğrafi bölgemiz olan Yozgat şehrinde GDM ile kan grupları arasındaki ilişkiyi değerlendirmeyi amaçladık.Gereç veYöntemRetrospektif olan çalışmamıza 1873 gebe kadın alınmıştır. Ocak 2018- Aralık 2019 tarihleri arasında kliniğimize başvuran, 24-28. gebelik haftalarında olan hastalarındosyaları incelenmiştir. Hastaların dosyalarından OGTT (Oral Glukoz Tolerans Testi) sonuçları ve kan grupları bulunmuştur. OGTT sonuçları ile kan grubu arasındakiilişki incelenmiştir.Bulgular OGTT sonucuna göre 326 (%17,40, yaş: 31,40±5,70) olgu GDM tanısı alırken 1547 (% 82,60 yaş: 29±5,10) kişi normal (kontrol) olarak saptanmıştır. GDM ve kontrol grubuiçin kan grupları sırasıyla A grubu %41,70- %45, B grubu %19,90-15,80, AB grubu %4,30-7,20 ve O grubu %34-32 olarak tespit edilmiştir. Gruplar arasında istatistikselolarak anlamlı düzeyde fark saptanmamıştır. Kontrol ve GDM grubunda Rh faktör pozitifliği yüzdesi sırasıyla %88,10 ve %89,60 olup gruplar arasında anlamlı farksaptanmamıştır.Sonuç Non-AB kan gruplarına sahip gebe kadınların, anlamlı fark saptanmamakla birlikte, artmış GDM riskine sahip olduklarını gözlemledik (%7,20 ve %4,30). Tespit ettiğimizkan grubu dağılımları genel popülasyonla benzer olup coğrafyamıza özgü farklılıklar da içermemektedir.Objective Gestational Diabetes Mellitus (GDM) is a clinical condition with increasing frequency and has been shown to be associated with perinatal complications. The relationship between GDM and blood groups is unclear. In this study, we aimed to evaluate the relationship between GDM and blood groups in Yozgat, which is our own geographical region. Materials and methods In our retrospective study, 1873 patient were included. The data of 1873 pregnant women who applied to our clinic between January 2018 and December 2019 and who are at gestational weeks between 24-28 were examined. OGTT (Oral Glucose Tolerance Test) test results and blood groups were recorded and analyzed. Results According to the result of OGTT, 326 (17,40%, age: 31,40± 5,70) cases were diagnosed as GDM, while 1547 (82,6%, age: 29 ± 5,10) were normal (control). Blood groups for GDM and control groups were defined as group A 41,70-45%, group B 19,90-15,80%, group AB 4,30-7,20% and group O 34-32%, respectively. There was no statistically significant difference between the groups. Rh positivity percentages in the control and GDM groups were 88,10% and 89,60%, respectively. There was no statistically significant difference between the groups. Conclusion We observed that pregnant women with non-AB blood group had an increased risk of GDM, but this difference was not significant (7,20% vs. 4,30%). The blood group distributions that we detected are similar to the general population and do not include specific differences to our geography

Chronic myeloid leukemia presented with priapism: Effective management with prompt leukapheresis

Priapism is a painful medical condition in which the erect penis does not return to its flaccid state, despite the absence of both physical and psychological stimulation, within 4 h. Priapism is considered a medical emergency, which should receive proper treatment by a qualified medical practitioner. Treatment initially involves conservative measures, such as corporeal aspiration and irrigation with saline or dilute phenylephrine. If this fails, embolization or surgical shunting may be required. Priapism is more commonly associated with sickle cell hemoglobinopathy. However, hyperviscosity resulting from leukemia is a rare cause of priapism. We report a case of a 19-year-old man with an 18-h history of priapism secondary to undiagnosed chronic myeloid leukemia. We discuss the method of leukapheresis ( mechanical white cell depletion) to reduce viscosity

A patient-based study on the adherence of physicians to guidelines for the management of type 2 diabetes in Turkey

Conclusions: Overall guideline adherence of physicians was suboptimal. Educational programs emphasizing the preventive aspect of diabetes management, targeted towards family practitioners and state institutions, may improve guideline adherence and patient outcome. (C) 2012 Elsevier Ireland Ltd. All rights reserved

Temporal changes in some Rajiformes species of cartilaginous fish (Chondrichthyes) from the west coast of İskenderun Bay (northeastern Mediterranean)

Some Rajiformes species among the cartilaginous fish (Chondrichthyes) that are distributed on the west coast of the Gulf of İskenderun were seasonally obtained by bottom trawling from 2 different depth layers between the years 2004 and 2011. The spatiotemporal changes in catch per unit effort (CPUE) values were investigated by considering 2 depth contours (10 and 20 m). Six species belonging to 6 different Rajiformes families were identified during the sampling period, including Dasyatis pastinaca (common stingray), Gymnura altavela (spiny butterfly ray), Rhinobatos rhinobatos (common guitarfish), Raja radula (rough ray), Myliobatis aquila (common eagle ray), and Torpedo marmorata (marbled electric ray). A general linear model was used to analyze the changes in the total and separate weights of cartilaginous fish. For this purpose, the logarithms of CPUE values in weight were classed according to the depth, season, and years. Seasonal variations and year-season 2-way interactions were found to be highly significant for total cartilaginous CPUE values (P < 0.01). The annual changes in R. rhinobatos were the only significant annual difference (P < 0.05), while the year-season interactions of D. pastinaca were found to be significant (P < 0.01). The seasonal variations of D. pastinaca and G. altavela were also highly significant (P < 0.01).Some Rajiformes species among the cartilaginous fish (Chondrichthyes) that are distributed on the west coast of the Gulf of İskenderun were seasonally obtained by bottom trawling from 2 different depth layers between the years 2004 and 2011. The spatiotemporal changes in catch per unit effort (CPUE) values were investigated by considering 2 depth contours (10 and 20 m). Six species belonging to 6 different Rajiformes families were identified during the sampling period, including Dasyatis pastinaca (common stingray), Gymnura altavela (spiny butterfly ray), Rhinobatos rhinobatos (common guitarfish), Raja radula (rough ray), Myliobatis aquila (common eagle ray), and Torpedo marmorata (marbled electric ray). A general linear model was used to analyze the changes in the total and separate weights of cartilaginous fish. For this purpose, the logarithms of CPUE values in weight were classed according to the depth, season, and years. Seasonal variations and year-season 2-way interactions were found to be highly significant for total cartilaginous CPUE values (P < 0.01). The annual changes in R. rhinobatos were the only significant annual difference (P < 0.05), while the year-season interactions of D. pastinaca were found to be significant (P < 0.01). The seasonal variations of D. pastinaca and G. altavela were also highly significant (P < 0.01)

Correlation between D-dimer levels and coronary artery reperfusion in acute myocardial infarction patients after thrombolytic treatment

The correlation between plasma D-dimer level and reperfusion has not been clarified yet in thrombolytic therapy applied for acute myocardial infarction patients. The aim of this study was to investigate whether there is a relationship between reperfusion and fibrinolytic activity in acute myocardial infarction patients treated with thrombolytic therapy. Fibrinolytic activity was reflected by plasma D-dimer levels. During the study period, 186 patients were initially analyzed. But 18 of these patients were excluded from the study because they were not suitable for study criteria. Blood was collected from 168 acute myocardial infarction patients within first 6h. Intravenous tissue plasminogen activator (100mg) or streptokinase (1500000U) was applied to patients. Mean age of the patients was 58 (28-86) years and majority was men (86%). The number of anterior, inferior, and lateral myocardial infarction patients were 76 (45.2%), 85 (50.6%), and seven (4.2%), respectively. The mean time from symptom onset to thrombolytic application was 134 (95-212)min. Reperfusion occurred in 115 (68.5%) patients. D-dimer levels were markedly high after thrombolytic therapy versus before (155mg/dl, 362mg/dl, P<0.005). We compared the D-dimer values before and after thrombolytic therapy between reperfused group and the nonreperfused group (189-409mg/l in reperfused group, P=0.086; 82-258mg/l in the nonreperfused group, P=0.173). In conclusion, in this study, D-dimer levels were elevated markedly in patients with ST elevation myocardial infarction after thrombolytic therapy, but no significant difference was seen in D-dimer levels between the reperfused and nonreperfused groups

The effects of zoledronic acid treatment on depression and quality of life in women with postmenopausal osteoporosis: A clinical trial study

Background: Osteoporosis affects quality of life (QoL) and may lead to depression in women. he purpose of this study was to evaluate the effects of zoledronic acid (ZA) treatment on depression and QoL in women with postmenopausal osteoporosis (PO). Materials and Methods: A total of 88 newly diagnosed women with PO were included in this study. All patients were treated with once-yearly ZA (5 mg). A QoL questionnaire from the European Foundation for Osteoporosis and Beck Depression Inventory were given to patients at baseline and at 12 months. he results for baseline and post - 12th month were compared, and bone mineral density (BMD) levels were compared. Results: he consumption of once-yearly ZA (5 mg) treatment increases BMD at levels of lumbers 1-4 (P = 0.026), total Hip T score's P value is same as femoral neck (P: 0,033). ZA 5 mg treatment also improved QoL (P = 0.001) and reduced depression (P = 0.001). Conclusion: ZA treatment increases BMD levels and QoL while reducing depression. Once-yearly ZA (5 mg) may be considered for postmenopausal women as a first-line treatment