TV Vanguarda e os desafios da migração do analógico ao digital

This work is a reflection on the convergence of media and also examines the current change of analog to digital systems, and seek to understand the transformations that have begun to dawn with the rollout of digital interactive TV. In this scenario, the digital culture and the recent generation that has reference to that reality are analyzed. The object of study is the TV Vanguarda – affiliate of Rede Globo in Vale do Paraiba, interior of Sao Paulo. The paper presents proposals for the broadcasting television to make the necessary adjustments in the digital age and also discusses on the future production of content in TV (and on its website), as viewers of the XXI Century want to interact.O presente artigo faz uma reflexão sobre a convergência das mídias e também analisa a atual mudança de sistemas analógicos para digitais, além de buscar entender as transformações que já começam a despontar com a implantação da TV Digital interativa. Nesse cenário, a cultura digital e a recente geração, que tem como referência essa realidade, são analisadas. O objeto de estudo é a TV Vanguarda – afiliada da Rede Globo no Vale do Paraíba, interior de São Paulo. O trabalho apresenta propostas para que a emissora faça as adequações necessárias à era digital e também discute sobre o futuro da produção de conteúdo na televisão (e em seu sítio na internet), já queos telespectadores do século XXI querem, cada vez mais, interagir

PDXNet portal: patient-derived Xenograft model, data, workflow and tool discovery

We created the PDX Network (PDXNet) portal (https://portal.pdxnetwork.org/) to centralize access to the National Cancer Institute-funded PDXNet consortium resources, to facilitate collaboration among researchers and to make these data easily available for research. The portal includes sections for resources, analysis results, metrics for PDXNet activities, data processing protocols and training materials for processing PDX data. Currently, the portal contains PDXNet model information and data resources from 334 new models across 33 cancer types. Tissue samples of these models were deposited in the NCI's Patient-Derived Model Repository (PDMR) for public access. These models have 2134 associated sequencing files from 873 samples across 308 patients, which are hosted on the Cancer Genomics Cloud powered by Seven Bridges and the NCI Cancer Data Service for long-term storage and access with dbGaP permissions. The portal includes results from freely available, robust, validated and standardized analysis workflows on PDXNet sequencing files and PDMR data (3857 samples from 629 patients across 85 disease types). The PDXNet portal is continuously updated with new data and is of significant utility to the cancer research community as it provides a centralized location for PDXNet resources, which support multi-agent treatment studies, determination of sensitivity and resistance mechanisms, and preclinical trials