Endocast morphology of Homo naledi from the Dinaledi Chamber, South Africa

Hominin cranial remains from the Dinaledi Chamber, South Africa, represent multiple individuals of the species Homo naledi. This species exhibits a small endocranial volume comparable to Australopithecus, combined with several aspects of external cranial anatomy similar to larger-brained species of Homo such as Homo habilis and Homo erectus. Here, we describe the endocast anatomy of this recently discovered species. Despite the small size of the H. naledi endocasts, they share several aspects of structure in common with other species of Homo, not found in other hominins or great apes, notably in the organization of the inferior frontal and lateral orbital gyri. The presence of such structural innovations in a small-brained hominin may have relevance to behavioral evolution within the genus Homo

Evolving skills for emerging technologies: a collaborative approach

Purpose The purpose of this paper is to discuss the implementation of a skills development project aimed at increasing the technology competencies of participating librarians in Columbia University’s Science & Engineering Libraries, in response to changing instructional needs. Design/methodology/approach Adopting a DIY or Maker learning model gave librarians a perfect opportunity to experience learning new technology skills just as their users encounter them. Findings The authors conclude that this collaborative project methodology could potentially fit a large variety of different library environments, providing other institutions with an excellent opportunity to reassess and revamp staff skills, no matter their instructional focus. Originality/value The literature notes that previous library staff training models were largely devised for newly matriculated Library and Information Science graduates preparing to enter the workforce. Burgeoning technology developments require libraries to explore novel methods to expose staff to new technology skills; this case study applies the programmatic lens of the Maker Movement to a collaborative staff learning model

Cooperative transcription activation by Nurr1 and Pitx3 induces embryonic stem cell maturation to the midbrain dopamine neuron phenotype

Midbrain dopamine (DA) neurons play a central role in the regulation of voluntary movement, and their degeneration is associated with Parkinson’s disease. Cell replacement therapies, and in particular embryonic stem (ES) cell-derived DA neurons, offer a potential therapeutic venue for Parkinson’s disease. We sought to identify genes that can potentiate maturation of ES cell cultures to the midbrain DA neuron phenotype. A number of transcription factors have been implicated in the development of midbrain DA neurons by expression analyses and loss-of-function knockout mouse studies, including Nurr1, Pitx3, Lmx1b, Engrailed-1, and Engrailed-2. However, none of these factors appear sufficient alone to induce the mature midbrain DA neuron phenotype in ES cell cultures in vitro, suggesting a more complex regulatory network. Here we show that Nurr1 and Pitx3 cooperatively promote terminal maturation to the midbrain DA neuron phenotype in murine and human ES cell cultures