8 research outputs found
AVALIAÇÃO DOS IMPACTOS AMBIENTAIS NOS ATRATIVOS ECOTURÍSTICOS DA ILHA DE SÃO FRANCISCO DO SUL, SC.
O ecoturismo é uma atividade turística que promove a interação sustentável do turista com o patrimônio natural e cultural. Determinar os efeitos desta atividade sobre o meio ambiente é fundamental para sua conservação. O presente estudo objetivou avaliar os impactos ambientais negativos em doze atrativos ecoturísticos da ilha de São Francisco do Sul, por meio de indicadores biofísicos. Constatamos que a degradação da vegetação, a ausência da fauna no entorno e a presença de lixo foram os impactos mais presentes nas áreas estudadas. Averiguamos também que os pontos ecoturísticos mais impactados são os mais urbanizados
Protocol of a phase II trial
Background Current studies on salvage radiotherapy (sRT) investigate timing,
dose-escalation and anti-hormonal treatment (ADT) for recurrent prostate
cancer. These approaches could either be limited by radiation-related
susceptibility of the anastomosis or by suspected side-effects of long-term
ADT. A phase II protocol was developed to investigate the benefit and
tolerability of regional hyperthermia with moderately dose-escalated
radiotherapy. Methods The study hypothesis is that radio-thermotherapy is a
safe and feasible salvage treatment modality. The primary endpoint is safety
measured by frequency of grade 3+ genitourinary (GU) and gastrointestinal (GI)
adverse events (AE) according to Common Toxicity Criteria (CTC) version 4.
Feasibility is defined by number of hyperthermia treatments (n ≥ 7) and
feasibility of radiotherapy according to protocol. Target volume delineation
is performed according to the EORTC guidelines. Radiation treatment is
administered with single doses of 2 Gy 5×/week to a total dose of 70 Gy.
Regional hyperthermia is given 2×/week to a total of 10 treatments. Results
European centres participate in the phase II trial using intensity modulated
RT (IMRT) or volumetric modulated arc technique (VMAT). The initiating centres
were participants of the SAKK 09/10 study, where the same patient criteria and
target volume definition (mandatory successful performed dummy run) were
applied insuring a high standardisation of the study procedures. Conclusions
The introduced phase II study implements highly precise image-guided
radiotherapy and regional hyperthermia. If the phase II study is found to be
safe and feasible, a multicenter phase III study is planned to test whether
the addition of regional hyperthermia to dose-intensified sRT improves
biochemical control
<b>Autoeficácia da gestante para o Aleitamento Materno: estudo transversal/ Self-efficacy of the pregnant woman for breastfeeding: cross-sectional study<b>
Assessment of different methods for the detection of biofilm production in coagulase-negative staphylococci isolated from blood cultures of newborns
Abstract INTRODUCTION: Coagulase-negative staphylococci (CoNS) are a frequent cause of bacteremia, especially in neonates. The major virulence determinant in CoNS is the ability to produce biofilms, which is conferred by the icaADBC genes. This study aimed to assess different methods for the detection of biofilm formation in 176 CoNS isolates from blood cultures of newborns. METHODS: The presence of the icaACD genes was assessed by polymerase chain reaction (PCR), and biofilm formation was assessed on congo red agar (CRA), by the tube method (TM), and on tissue culture plates (TCP). RESULTS: Of the 176 CoNS isolates, 30.1% expressed icaACD and 11.4% expressed icaAD. The CRA assay and TM showed that 42% and 38.6% of the isolates were biofilm producing, respectively. On TCP, 40.9% of the isolates produced biofilms; 21% were weakly adherent and 19.9% were strongly adherent. When compared to the gold standard technique (PCR), the CRAassay showed 79% sensitivity and 84% specificity (kappa = 0.64), TM showed 78% sensitivity and 89% specificity (kappa = 0.68), and TCP showed 99% sensitivity and 100% specificity (kappa = 0.99). CONCLUSIONS: In this study, ~42% of CoNS isolates produced biofilms, and the presence of icaACD was associated with a greater capacity to form biofilms. Compared to the other phenotypic methodologies, TCP is an ideal procedure for routine laboratory use
Abwehr – Aneignung – Widerspruch Diskursive Strategien der katholischen Spengler-Rezeption in Österreich
Similar occurrence of febrile episodes reported in non-atopic children at three to five years of age after prebiotics supplemented infant formula
This is a follow up study of a multicenter randomised placebo-controlled trial in seven centres in five West European countries. The RCT assessed the effect of infant formula supplemented with a mixture of prebiotics (with neutral short-chain and long-chain oligosaccharides and pectin-derived acidic oligosaccharides) during infancy in term-born children (n=1130). In the follow-up study 672 children (60% of the study population) participated: 232 (56%) from the prebiotics group (PG), 243 (58%) from the control group (CG), and 197 (66%) from the non-randomised breast-fed group (BG). The primary outcome was the occurrence of febrile episodes at three to five years of age prospectively documented by the parents: in the PG 1.17 (interquartile range 0.50-2.08) episodes per year versus 1.20 (0.52-2.57) in the CG; and 1.48 (0.65-2.60) in the BG. This specific prebiotics mixture given during infancy in healthy non-atopic subjects does not decrease febrile episodes and therefore seems not to prevent infection between their third and fifth birthday
Similar occurrence of febrile episodes reported in non-atopic children at three to five years of age after prebiotics supplemented infant formula
This is a follow up study of a multicenter randomised placebo-controlled trial in seven centres in five West European countries. The RCT assessed the effect of infant formula supplemented with a mixture of prebiotics (with neutral short-chain and long-chain oligosaccharides and pectin-derived acidic oligosaccharides) during infancy in term-born children (n=1130). In the follow-up study 672 children (60% of the study population) participated: 232 (56%) from the prebiotics group (PG), 243 (58%) from the control group (CG), and 197 (66%) from the non-randomised breast-fed group (BG). The primary outcome was the occurrence of febrile episodes at three to five years of age prospectively documented by the parents: in the PG 1.17 (interquartile range 0.50-2.08) episodes per year versus 1.20 (0.52-2.57) in the CG; and 1.48 (0.65-2.60) in the BG. This specific prebiotics mixture given during infancy in healthy non-atopic subjects does not decrease febrile episodes and therefore seems not to prevent infection between their third and fifth birthday