Upscaling of a local model into a larger-scale model

Traditionally, in order for lower-resolution, global- or basin-scale (regional) models to benefit from some of the improvements available in higher-resolution subregional or coastal models, two-way nesting has to be used. This implies that the parent and child models have to be run together and there is an online exchange of information between both models. This approach is often impossible in operational systems where different model codes are run by different institutions, often in different countries. Therefore, in practice, these systems use one-way nesting with data transfer only from the parent model to the child models. In this article, it is examined whether it is possible to replace the missing feedback (coming from the child model) by data assimilation, avoiding the need to run the models simultaneously. Selected variables from the high-resolution simulation will be used as pseudo-observations and assimilated into the low-resolution models. This method will be called “upscaling”. A realistic test case is set up with a model covering the Mediterranean Sea, and a nested model covering its north-western basin. Under the hypothesis that the nested model has better prediction skills than the parent model, the upscaling method is implemented. Two simulations of the parent model are then compared: the case of one-way nesting (or a stand-alone model) and a simulation using the upscaling technique on the temperature and salinity variables. It is shown that the representation of some processes, such as the Rhône River plume, is strongly improved in the upscaled model compared to the stand-alone model.</p

Study of the combined effects of data assimilation and grid nesting in ocean models - application to the Gulf of Lions

Modern operational ocean forecasting systems routinely use data assimilation techniques in order to takeobservations into account in the hydrodynamic model. Moreover, as end users require higher and higher resolution predictions, especially in coastal zones, it is now common to run nested models, where the coastal model gets its opensea boundary conditions from a low-resolution global model. This configuration is used in the “Mediterranean Forecasting System: Towards environmental predictions” (MFSTEP) project. A global model covering the whole Mediterranean Sea is run weekly, performing 1 week of hindcast and a 10-day forecast. Regional models, using different codes and covering different areas, then use this forecast to implement boundary conditions. Local models in turn use the regional model forecasts for their own boundary conditions. This nested system has proven to be a viable and efficient system to achieve high-resolution weekly forecasts. However, when observations are available in some coastal zone, it remains unclear whether it is better to assimilate them in the global or local model. We perform twin experiments and assimilate observations in the global or in the local model, or in both of them together. We show that, when interested in the local models forecast and provided the global model fields are approximately correct, the best results are obtained when assimilating observations in the local model

Gehechtheid als beïnvloedende factor van gedrags- en psychologische symptomen bij dementie

De laatste jaren wordt in toenemende mate het belang van hechting op oudere leeftijd erkend. Getuigen daarvan zijn vele onderzoekingen die gebeurden in de voorbije drie decennia. In dit artikel geven we een overzicht van de belangrijkste resultaten met speciale aandacht voor onderzoek naar hechting en dementie. Studies suggereren dat het aantal hechtingsfiguren afneemt op oudere leeftijd. Daarentegen wordt de plaats van volwassen kinderen, een overleden partner en God prominenter. Ook blijkt dat de hechtingsangst daalt naarmate mensen ouder worden, terwijl hechtingsvermijding relatief stabiel blijft. Veilige gehechtheid is verder positief gerelateerd met groter welzijn en een positievere visie op ouder worden in vergelijking met meer onveilig gehechte individuen. Onveilige gehechtheid hangt ook samen met een toename van gedragsen psychologische problemen bij dementerende ouderen. Bij de zorgverlener zijn draaglast en depressiviteit, evenals de wijze waarop zorg opgenomen wordt en het engagement naar de toekomst toe, verschillend afhankelijk van de hechtingsstijl. Conform deze bevindingen lijken hechtingsgebaseerde interventies een positief effect op gedrags- en psychologische symptomen bij dementie te hebben, maar meer onderzoek is hier duidelijk nodig. Tot slot is er nog een weg af te leggen wat betreft uniformisering en validering van meetmethoden voor hechting op oudere leeftijd

Brain Changes Induced by Electroconvulsive Therapy Are Broadly Distributed

© 2019 Society of Biological Psychiatry Background: Electroconvulsive therapy (ECT) is associated with volumetric enlargements of corticolimbic brain regions. However, the pattern of whole-brain structural alterations following ECT remains unresolved. Here, we examined the longitudinal effects of ECT on global and local variations in gray matter, white matter, and ventricle volumes in patients with major depressive disorder as well as predictors of ECT-related clinical response. Methods: Longitudinal magnetic resonance imaging and clinical data from the Global ECT-MRI Research Collaboration (GEMRIC) were used to investigate changes in white matter, gray matter, and ventricle volumes before and after ECT in 328 patients experiencing a major depressive episode. In addition, 95 nondepressed control subjects were scanned twice. We performed a mega-analysis of single subject data from 14 independent GEMRIC sites. Results: Volumetric increases occurred in 79 of 84 gray matter regions of interest. In total, the cortical volume increased by mean ± SD of 1.04 ± 1.03% (Cohen\u27s d = 1.01, p \u3c .001) and the subcortical gray matter volume increased by 1.47 ± 1.05% (d = 1.40, p \u3c .001) in patients. The subcortical gray matter increase was negatively associated with total ventricle volume (Spearman\u27s rank correlation ρ = −.44, p \u3c .001), while total white matter volume remained unchanged (d = −0.05, p = .41). The changes were modulated by number of ECTs and mode of electrode placements. However, the gray matter volumetric enlargements were not associated with clinical outcome. Conclusions: The findings suggest that ECT induces gray matter volumetric increases that are broadly distributed. However, gross volumetric increases of specific anatomically defined regions may not serve as feasible biomarkers of clinical response

Relationship between spatial proximity and travel-to-work distance : the effect of the compact city

In this paper, an assessment is made of the relationship between selected aspects of spatial proximity (density, diversity, minimum commuting distance, jobs-housing balance and job accessibility) and reported commuting distances in Flanders (Belgium). Results show that correlations may depend on the considered trip end. For example, a high residential density, a high degree of spatial diversity and a high level of job accessibility are all associated with a short commute by residents, while a high job density is associated with a long commute by employees. A jobs-housing balance close to one is associated with a short commute, both by residents and by employees. In general, it appears that the alleged sustainability benefits of the compact city model are still valid in a context of continuously expanding commuting trip lengths

A European Academy of Neurology guideline on medical management issues in dementia

BACKGROUND AND PURPOSE: Dementia is one of the most common disorders and is associated with increased morbidity, mortality and decreased quality of life. The present guideline addresses important medical management issues including systematic medical follow‐up, vascular risk factors in dementia, pain in dementia, use of antipsychotics in dementia and epilepsy in dementia. METHODS: A systematic review of the literature was carried out. Based on the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) framework, we developed a guideline. Where recommendations based on GRADE were not possible, a good practice statement was formulated. RESULTS: Systematic management of vascular risk factors should be performed in patients with mild to moderate dementia as prevention of cerebrovascular pathology may impact on the progression of dementia (Good Practice statement). Individuals with dementia (without previous stroke) and atrial fibrillation should be treated with anticoagulants (weak recommendation). Discontinuation of opioids should be considered in certain individuals with dementia (e.g. for whom there are no signs or symptoms of pain or no clear indication, or suspicion of side effects; Good Practice statement). Behavioral symptoms in persons with dementia should not be treated with mild analgesics (weak recommendation). In all patients with dementia treated with opioids, assessment of the individual risk–benefit ratio should be performed at regular intervals. Regular, preplanned medical follow‐up should be offered to all patients with dementia. The setting will depend on the organization of local health services and should, as a minimum, include general practitioners with easy access to dementia specialists (Good Practice statement). Individuals with dementia and agitation and/or aggression should be treated with atypical antipsychotics only after all non‐pharmacological measures have been proven to be without benefit or in the case of severe self‐harm or harm to others (weak recommendation). Antipsychotics should be discontinued after cessation of behavioral disturbances and in patients in whom there are side effects (Good Practice statement). For treatment of epilepsy in individuals with dementia, newer anticonvulsants should be considered as first‐line therapy (Good Practice statement). CONCLUSION: This GRADE‐based guideline offers recommendations on several important medical issues in patients with dementia, and thus adds important guidance for clinicians. For some issues, very little or no evidence was identified, highlighting the importance of further studies within these areas

Black sea observing system

The ultimate goal of modern operational oceanography are end user oriented products with high scientific quality. Beneficiaries are the governmental services, coast and offshore based enterprises and research institutions that make use of the products generated by operational oceanography. Direct users are coastal managers, shipping, search and rescue, oil spill combat, offshore industry, ports, fishing, tourism, and recreation industry. Indirect beneficiaries, through climate forecasting based on ocean observations, are food, energy, water and medical suppliers. Availability of updated information on the actual state as well as forecast of marine environment is essential for the success and safety of maritime operations in the offshore industry. Various systems for the collection and presentation of marine data for the needs of different users have been developed and put in operation in the Black Sea. The systems are located both along the coast and in the open sea and the information they provide is used by both the maritime industry and the widest range of users. The Black Sea Monitoring and Forecasting Center in the frame of the Copernicus Marine Service is providing regular and systematic information about the physical state of the ocean, marine ecosystem and wave conditions in the Black Sea area, assimilating observations, keeping efficient operations, advanced technology and high quality modeling products. Combining and optimizing in situ, remote sensing, modeling and forecasting into a Black Sea observing system is a task that has to be solved, and that will allow to get a more complete and comprehensive picture of the state of the marine environment as well as to forecast future changes of physical and biogeochemical state of the Black Sea and the Black Sea ecosystem

Are Apathy and Depressive Symptoms Related to Vascular White Matter Hyperintensities in Severe Late Life Depression?

OBJECTIVE: Apathy symptoms are defined as a lack of interest and motivation. Patients with late-life depression (LLD) also suffer from lack of interest and motivation and previous studies have linked apathy to vascular white matter hyperintensities (WMH) of the brain in depressed and nondepressed patients. The aim of this study was to investigate the relationship between apathy symptoms, depressive symptoms, and WMH in LLD. We hypothesize that late-onset depression (LOD; first episode of depression after 55 years of age) is associated with WMH and apathy symptoms. METHODS: Apathy scores were collected for 87 inpatients diagnosed with LLD. Eighty patients underwent brain magnetic resonance imaging. Associations between depressive and apathy symptoms and WMH were analyzed using linear regression. RESULTS: All 3 subdomains of the 10-item Montgomery–Åsberg Depression Rating Scale correlated significantly with the apathy scale score (all P < .05). In the total sample, apathy nor depressive symptoms were related to specific WMH. In LOD only, periventricular WMH were associated with depression severity (β = 5.21, P = .04), while WMH in the left infratentorial region were associated with apathy symptoms (β coefficient = 5.89, P = .03). CONCLUSION: Apathy and depressive symptoms are highly overlapping in the current cohort of older patients with severe LLD, leading to the hypothesis that apathy symptoms are part of depressive symptoms in the symptom profile of older patients with severe LLD. Neither apathy nor depressive symptoms were related to WMH, suggesting that radiological markers of cerebrovascular disease, such as WMH, may not be useful in predicting these symptoms in severe LLD