Wind utilization in remote regions: An economic study

A wind driven generator was considered as a supplement to a diesel group, for the purpose of economizing fuel when wind power is available. A specific location on Hudson's Bay, Povognituk, was selected. Technical and economic data available for a wind machine of 10-kilowatt nominal capacity and available wind data for that region were used for the study. After subtracting the yearly wind machine costs from savings in fuel costs, a net savings of $1400 per year is realized. These values are approximate, but are though to be highly conservative

Design and fabrication of liquid nitrogen thermal shields for the MFTF yin-yang magnets

This paper documents the design and fabrication of thin liquid nitrogen-cooled panels installed on the 340-ton MFTF yin-yang superconducting magnet system. The 344 panels are made of polished 316-L stainless steel with the pillowed fluid channels formed by inflation with a high pressure gas. Strict leak-rate limits required the manufacturer to thermal shock the panels with LN/sub 2/ and then vacuum leak check them with He. The thin-walled panel supports are made from an epoxy base, fiberglass composite which is reliable at cryogenic vacuum conditions. Quick and reliable welding of the manifold system was assured using a pair of automated tube welders on the more than 4000 feet of tubing and 1000 butt-weld fittings. To assure sufficient flow for single-phase LN/sub 2/ flow conditions, we performed a hydraulic network flow analysis. This allowed for some optimization of shield-inlet-flow conditions and manifold design. To verify operating fluid pressure and temperature, special pressure transducers and platinum resistance thermometers capable of operation at cryogenic conditions in a vacuum, high magnetic field, and long-term neutron bombardment were installed. Final assembly is complete. The final installation on the magnet was difficult due to the orientation of the magnet assembly and the restricted access to some installation surfaces

Cryogenic system for the mirror fusion test facility

The Mirror Fusion Test Facility (MFTF), currently being constructed at the Lawrence Livermore Laboratory, has large superconducting magnets, cryopanels, and supporting cryogenic equipment that will comprise one of the world's largest liquid helium (LHe) systems. The facility will provide mirror magnetic confinement for experimental fusion plasmas that will be approximately the same physical size as if in a conceptual fusion reactor. The cryogenic system typifies the magnitude and makeup of systems that will be used in future magnetic fusion reactors. Here we describe the LHe cryopumping and magnet systems. Principal components include a 3300 W helium refrigerator, 30,000 L LHe storage, a 1.5 MW (2000 hp) refrigerator compressor, 1100 m/sup 2/ of cryopanels, and a 420 MJ superconducting magnet system. Design features, method of operation, thermal protection, and helium recovery operations are discussed

Correlation Between Bulk Material Defects and Spectroscopic Response in Cadmium Zinc Telluride Detectors

One of the critical challenges for large area cadmium zinc telluride (CdZnTe) detector arrays is obtaining material capable of uniform imaging and spectroscopic response. Two complementary nondestructive techniques for characterizing bulk CdZnTe have been developed to identify material with a uniform response. The first technique, infrared transmission imaging, allows for rapid visualization of bulk defects. The second technique, x-ray spectral mapping, provides a map of the material spectroscopic response when it is configured as a planar detector. The two techniques have been used to develop a correlation between bulk defect type and detector performance. The correlation allows for the use of infrared imaging to rapidly develop wafer mining maps. The mining of material free of detrimental defects has the potential to dramatically increase the yield and quality of large area CdZnTe detector arrays

Evolution of Linear Absorption and Nonlinear Optical Properties in V-Shaped Ruthenium(II)-Based Chromophores

In this article, we describe a series of complexes with electron-rich cis-{Ru^(II)(NH_3)_4}^(2+) centers coordinated to two pyridyl ligands bearing N-methyl/arylpyridinium electron-acceptor groups. These V-shaped dipolar species are new, extended members of a class of chromophores first reported by us (Coe, B. J. et al. J. Am. Chem. Soc. 2005, 127, 4845−4859). They have been isolated as their PF_6− salts and characterized by using various techniques including ^1H NMR and electronic absorption spectroscopies and cyclic voltammetry. Reversible Ru^(III/II) waves show that the new complexes are potentially redox-switchable chromophores. Single crystal X-ray structures have been obtained for four complex salts; three of these crystallize noncentrosymmetrically, but with the individual molecular dipoles aligned largely antiparallel. Very large molecular first hyperpolarizabilities β have been determined by using hyper-Rayleigh scattering (HRS) with an 800 nm laser and also via Stark (electroabsorption) spectroscopic studies on the intense, visible d → π^* metal-to-ligand charge-transfer (MLCT) and π → π^* intraligand charge-transfer (ILCT) bands. The latter measurements afford total nonresonant β_0 responses as high as ca. 600 × 10^(−30) esu. These pseudo-C_(2v) chromophores show two substantial components of the β tensor, β_(zzz) and β_(zyy), although the relative significance of these varies with the physical method applied. According to HRS, β_(zzz) dominates in all cases, whereas the Stark analyses indicate that β_(zyy) is dominant in the shorter chromophores, but β_(zzz) and β_(zyy) are similar for the extended species. In contrast, finite field calculations predict that β_(zyy) is always the major component. Time-dependent density functional theory calculations predict increasing ILCT character for the nominally MLCT transitions and accompanying blue-shifts of the visible absorptions, as the ligand π-systems are extended. Such unusual behavior has also been observed with related 1D complexes (Coe, B. J. et al. J. Am. Chem. Soc. 2004, 126, 3880−3891)

Mirror fusion test facility magnet system. Final design report

Information is given on each of the following topics: (1) magnet description, (2) superconducting manufacture, (3) mechanical behavior of conductor winding, (4) coil winding, (5) thermal analysis, (6) cryogenic system, (7) power supply system, (8) structural analysis, (9) structural finite element analysis refinement, (10) structural case fault analysis, and (11) structural metallurgy. (MOW

Anaesthetic Impairment of Immune Function Is Mediated via GABAA Receptors

GABA(A) receptors are members of the Cys-loop family of neurotransmitter receptors, proteins which are responsible for fast synaptic transmission, and are the site of action of wide range of drugs. Recent work has shown that Cys-loop receptors are present on immune cells, but their physiological roles and the effects of drugs that modify their function in the innate immune system are currently unclear. We are interested in how and why anaesthetics increase infections in intensive care patients; a serious problem as more than 50% of patients with severe sepsis will die. As many anaesthetics act via GABA(A) receptors, the aim of this study was to determine if these receptors are present on immune cells, and could play a role in immunocompromising patients.We demonstrate, using RT-PCR, that monocytes express GABA(A) receptors constructed of α1, α4, β2, γ1 and/or δ subunits. Whole cell patch clamp electrophysiological studies show that GABA can activate these receptors, resulting in the opening of a chloride-selective channel; activation is inhibited by the GABA(A) receptor antagonists bicuculline and picrotoxin, but not enhanced by the positive modulator diazepam. The anaesthetic drugs propofol and thiopental, which can act via GABA(A) receptors, impaired monocyte function in classic immunological chemotaxis and phagocytosis assays, an effect reversed by bicuculline and picrotoxin.Our results show that functional GABA(A) receptors are present on monocytes with properties similar to CNS GABA(A) receptors. The functional data provide a possible explanation as to why chronic propofol and thiopental administration can increase the risk of infection in critically ill patients: their action on GABA(A) receptors inhibits normal monocyte behaviour. The data also suggest a potential solution: monocyte GABA(A) receptors are insensitive to diazepam, thus the use of benzodiazepines as an alternative anesthetising agent may be advantageous where infection is a life threatening problem

Interactions between metal oxides and biomolecules: from fundamental understanding to applications

Metallo-oxide (MO) based bioinorganic nanocomposites promise unique structures, physico-chemical properties and novel bio-chemical functionalities and within the last decade, investment in research on materials such as ZnO, TiO2, SiO2 and GeO2 has significantly increased. Besides traditional approaches, the synthesis, shaping, structural patterning and post-processing chemical functionalization of the materials surface is inspired by strategies which mimic processes in nature. Would such materials deliver new technologies? Answering this question requires the merging of historical knowledge and current research from different fields of science. Practically, we need an effective defragmentation of the research area. From our perspective, the superficial accounting of material properties, chemistry of the surfaces and the behaviour of biomolecules next to such surfaces is a problem. This is particularly of concern when we wish to bridge between technologies in vitro and biotechnologies in vivo. Further, besides the potential practical technological efficiency and advantages such materials might exhibit, we have to consider the wider long-term implications of material stability and toxicity. In this contribution we present a critical review of recent advances in the chemistry and engineering of MO based biocomposites highlighting the role of interactions at the interface and the techniques by which these can be studied. At the end of the article we outline the challenges which hamper progress in research and extrapolate to developing and promising directions including additive manufacturing and synthetic biology that could benefit from molecular level understanding of interactions occurring between inanimate (abiotic) and living (biotic) materials