Towards a eucharistic theology and practice for the South African context : a re-appraisal of Reformed eucharistic theology from the perspective of the Eucharist in Catholic liberation theology

Bibliography: pages 102-105.The theology and practice of the eucharist emerged as one of the major points of contention in the 16th Century Reformation. While the Reformers themselves differed in their respective eucharistic theologies, they were nevertheless unanimous in rejecting what they perceived as heresy and abuse in the theology and practice within the Roman Catholic Church. Part One of this dissertation explores the Reformed teaching on the eucharist by surveying the eucharistic theologies of the Reformers, Huldrych Zwingli and John Calvin, and more recent theologians, Peter Forsyth and Karl Barth. The challenge of the Reformation, however timeous and valid, did not go far enough. While the Reformers went to great lengths to expose theological heresy and to condemn abuses, they gave scant attention to the contextual implications of their theology. For instance, the Reformation focussed on such theological issues as the "essence" or "substance" of Christ's presence in the eucharist, without giving attention to its missiological implications within the contextual struggles for human liberation from socio-political and economic structures of domination, oppression and exploitation. Roman Catholic theology of liberation, emerging from Latin America in the latter part of the 20th Century, presents a compelling challenge to both traditional Catholic teaching and Reformed theology and practice. While not departing from the basic tenets of Catholic teaching, liberation theology adopts a radically critical stance, whereby any orthodox theology and practice is judged in terms of its relevance to the existential situations of human oppression, poverty and suffering. Part Two of this dissertation reflects on the response of liberation theologians to a new crisis for the sacraments within the Roman Catholic Church. This is done by surveying the eucharistic theologies of Juan Luis Segundo, Rafael Avila (from Latin America) and Tissa Balasuriya (from Asia). The Churches of the Reformed tradition have not as yet adequately responded to the challenges within a country characterised by racism, state oppression, social injustices and economic exploitation. A Reformed eucharistic theology and practice should be formulated for the South African context, which takes seriously the criticisms of Catholic liberation theology, while simultaneously exploring the contextual implications of its own Reformed tradition. It is not necessary for a Reformed understanding of the eucharist to break with tradition, anymore than Catholic liberation theology does. What is required is that the tradition be retrieved in relation to the struggle for liberation within our historical context. Part Three sets out the proposal for a eucharistic theology and practice for the South African context, in terms of two major themes, namely those of protest and celebration. These themes are fundamental to both the biblical framework and the contextual application of the eucharist, are consonant with the intention of Reformed eucharistic theology. Central to the proposal will be the formulation of a theology and practice of the community-of-faith. It will become evident as to what is meant by community-of-faith as we explore the above themes

The legacy of a prophetic moment : a socio-theological study of the reception and response to the Kairos Document amongst churches faith- communities and individuals in South Africa and within the international ecumenical community focussing on the English-speaking churches in South Africa with special reference to the United Congregational Church of Southern Africa.

Thesis (Ph.D.) - University of Natal, Pietermaritzburg, 1998.The Kairos Document ('KD' or 'Document') burst onto the socio-political and ecclesiastical scene in South Africa in 1985, presenting to churches, communities-of-faith and individuals the challenge of a decisive moment in the history of Christian opposition to Apartheid. The nature and extent of reactions and responses to the document exceeded the authors wildest dreams and most optimistic of expectations. This study traces the contours and discerns the patterns of reactions against and resonances with the Document in South Africa and within the international ecumenical community. The main focus of this research, however, is on the propensity and capacity of the institutionalised churches - and in particular the English-speaking churches in South Africa - to respond positively and constructively to a prophetic challenge, such that which emanated from the KD and the subsequent Kairos movement. One of the English-speaking churches, the United Congregational Church of Southern Africa (UCCSA), is singled out in this thesis and subjected to an extended examination and analysis, relative to its response to the challenge of the Document. The main reason for this special reference to the UCCSA is that this church denomination had embarked on a major process of ecclesiastical and denominational transformation in its response to the challenge of Kairos. It is 'upon this process of transformation within the UCCSA that I seek to critically reflect and to draw some learnings from the prophetic legacy of the Document. The UCCSA also happens to be the church denomination in which I have been nurtured in Christian faith, practice and ministry. The work, worship and witness of this church is therefore the primary frame of reference and ecclesiastical context in which my own prophetic consciousness has been awakened and shaped. I am, as such, acutely aware that my research on the responses to the KD by the UCCSA is being undertaken from the perspectives of an insider and that my passion for and commitment to the prophetic role of the Church makes me no neutral observer. It is my contention, however, that the above factors neither compromise nor diminish the academic credibility and ecumenical significance of this study. On the contrary, my strategic positioning within the UCCSA enables me to undertake such research from a privileged vantage point of first-hand experience, readily accessible data and greater understanding which derives from such close proximity. Needless to say, I shall endeavour to be as rigorous and critical as possible in my appraisal of the UCCSA's response which, in the final analysis, is an integral part of my overall critique of the nature of the churches' responses to the prophetic challenge of the KD

OPTIMAL VELOCITY PROFILES FOR VAULT

The aim of this study was to determine which kinematic characteristics may be used as a performance indicator(s) for vault. Over 600 vaults (299 men and 216 Women, see Table 1) were recorded and analyzed using footage of 3 high-speed cameras taken at the 2010 Rotterdam Artistic Gymnastics World Championships. The kinematics were correlated with the judge’s outcome score: type of vault, difficulty and final score. The correlation coefficients between velocity at takeoff and final judges’ scores were r = 0.60 for men and r = 0.52 for women

Expression of 5'nucleotidase activity and wheat germ agglutinin binding sites in mononuclear phagocytes from bone marrow cultures

Contains fulltext : 4442.pdf (publisher's version ) (Open Access

Targeting the heterogeneous genomic landscape in triple-negative breast cancer through inhibitors of the transcriptional machinery

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer defined by lack of the estrogen, progesterone and human epidermal growth factor receptor 2. Although TNBC tumors contain a wide variety of oncogenic mutations and copy number alterations, the direct targeting of these alterations has failed to substantially improve therapeutic efficacy. This efficacy is strongly limited by interpatient and intratumor heterogeneity, and thereby a lack in uniformity of targetable drivers. Most of these genetic abnormalities eventually drive specific transcriptional programs, which may be a general underlying vulnerability. Currently, there are multiple selective inhibitors, which target the transcriptional machinery through transcriptional cyclin-dependent kinases (CDKs) 7, 8, 9, 12 and 13 and bromodomain extra-terminal motif (BET) proteins, including BRD4. In this review, we discuss how inhibitors of the transcriptional machinery can effectively target genetic abnormalities in TNBC, and how these abnormalities can influence sensitivity to these inhibitors. These inhibitors target the genomic landscape in TNBC by specifically suppressing MYC-driven transcription, inducing further DNA damage, improving anti-cancer immunity, and preventing drug resistance against MAPK and PI3K-targeted therapies. Because the transcriptional machinery enables transcription and propagation of multiple cancer drivers, it may be a promising target for (combination) treatment, especially of heterogeneous malignancies, including TNBC.Toxicolog

Mammary gland tumor promotion by chronic administration of IGF1 and the insulin analogue AspB10 in the p53R270H/⁺WAPCre mouse model

Insulin analogues are structurally modified molecules with altered pharmaco-kinetic and -dynamic properties compared to regular human insulin used by diabetic patients. While these compounds are tested for undesired mitogenic effects, an epidemiological discussion is ongoing regarding an association between insulin analogue therapy and increased cancer incidence, including breast cancer. Standard in vivo rodent carcinogenesis assays do not pick up this possible increased carcinogenic potential. Here we studied the role of insulin analogues in breast cancer development. For this we used the human relevant mammary gland specific p53R270H/⁺WAPCre mouse model. Animals received life long repeated treatment with four different insulin (-like) molecules: normal insulin, insulin glargine, insulin X10 (AspB10) or insulin-like growth factor 1 (IGF1). Insulin-like molecules with strong mitogenic signaling, insulin X10 and IGF1, significantly decreased the time for tumor development. Yet, insulin glargine and normal insulin, did not significantly decrease the latency time for (mammary gland) tumor development. The majority of tumors had an epithelial to mesenchymal transition phenotype (EMT), irrespective of treatment condition. Enhanced extracellular signaling related kinase (Erk) or serine/threonine kinase (Akt) mitogenic signaling was in particular present in tumors from the insulin X10 and IGF1 treatment groups. These data indicate that insulin-like molecules with enhanced mitogenic signaling increase the risk of breast cancer development. Moreover, the use of a tissue specific cancer model, like the p53R270H/⁺WAPCre mouse model, is relevant to assess the intrinsic pro-carcinogenic potential of mitogenic and non-mitogenic biologicals such as insulin analogues. INTRODUCTION METHODS RESULTS CONCLUSION

Sound absorbing glass: transparent solution for poor acoustics of monumental spaces

Monumental buildings are demolished when they lose their traditional function. These historical monuments can be maintained by repurposing them for modern use, like lectures and musical events. This results in a demand for different acoustic conditions. However, monuments are subject to strict building intervention regulations; any intervention concerning changes to the original elements are often prohibited. This creates a demand for demountable and adaptable product design, repurposing monumental buildings by alleviating acoustical problems without distorting the view towards the monumental elements. This research focused on developing sound absorption panels based on the micro-perforation principle: manufacturing these in thin glass panels, evaluating their influence on strength and transparency, optimizing sound absorption (perforation diameter and ratio) using a tailor-made computational model, and creating a pattern of perforations that optimizes strength

Sound absorbing glass: transparent solution for poor acoustics of monumental spaces

Monumental buildings are demolished when they lose their traditional function. These historical monuments can be maintained by repurposing them for modern use, like lectures and musical events. This results in a demand for different acoustic conditions. However, monuments are subject to strict building intervention regulations; any intervention concerning changes to the original elements are often prohibited. This creates a demand for demountable and adaptable product design, repurposing monumental buildings by alleviating acoustical problems without distorting the view towards the monumental elements. This research focused on developing sound absorption panels based on the micro-perforation principle: manufacturing these in thin glass panels, evaluating their influence on strength and transparency, optimizing sound absorption (perforation diameter and ratio) using a tailor-made computational model, and creating a pattern of perforations that optimizes strength

Evaluation of an imaging-based in vitro screening platform for estrogenic activity with OECD reference chemicals

Estrogen receptor alpha (ERα) is often a primary target of endocrine disrupting chemicals (EDCs) and therefore several biochemical and cell-based assays for the detection of chemicals with estrogenic properties have been developed in the past. However, the current approaches are not suitable for the monitoring of pathway activation dynamics, and they are mostly based on expression constructs that lack physiological promoter regulation. We recently developed MCF7 fluorescent reporter cell lines of 3 different green fluorescent protein (GFP)-tagged ERα target genes: GREB1, PGR and TFF1. These reporters are under control of the full physiological promoter region and allow the monitoring of dynamic pro-proliferative pathway activation on a single cell level using a live-cell imaging set-up. In this study, we systematically characterized the response of these reporters to a full reference compound set of known estrogenic and non-estrogenic chemicals as defined by the Organization for Economic Co-Operation and Development (OECD). We linked activation of the pro-proliferative ERα pathway to a potential adverse outcome by additionally monitoring cell cycle progression and proliferation. The correct classification of the OECD reference compounds showed that our reporter platform has the same sensitivity and specificity as other validated artificial ERα pathway reporters, such as the ERα CALUX and VM7 Luc ER TA assay. By monitoring several key events (i.e. ER target activation, cell cycle progression and proliferation), and subsequently determining Point-of-Departure (POD) values, our reporter panel can be used in high-throughput testing for a physiologically more relevant, quantitative temporal endocrine modulation analysis to improve human carcinogen risk assessment.Toxicolog