A Linguistic Research Programme for Reading in African Languages to underpin CAPS

Although ANAs show language conditioned problems in reading comprehension and decoding ability, most South African research focuses disproportionately on (a) English and Afrikaans and (b) macro approaches to literacy rather than formal and psycholinguistic analyses of reading. Obviously African languages are structurally and typologically different to English and Afrikaans; reading strategies required for the mechanics of reading are necessarily different and should be supported by language-specific pedagogies. We argue for research programmes that situate reading pedagogy within the language-specific spaces defined by Linguistic approaches to understanding (a) orthography, (b) cognitive reading skills and models and (c) indigenous, language-specific norms and resources.Keywords: psycholinguistics, linguistics, orthography, morphological awareness, phonological awareness, curriculum developmen

Quality of life and costs of Filgrastim® (G-CSF) treatment in patients with persistent chronic rhinosinusitis

This is the first report of the double blind randomized clinical trial, in which we investigated the influence of Filgrastim(r) on the quality of life and treatment costs of chronic sinusitis patients who did not respond to regular treatments. The quality of life of 56 patients was assessed 5 times during the 24-week trial with the EuroQol, the SF-36 and the McGill Pain questionnaire. We further controlled for "responsiveness", based on clinical impression. Direct medical and indirect non-medical costs per patient during the trial were analyzed, based on data from clinical record forms and the hospital information system. We further compared the direct medical costs to the costs of regular treatment. The quality of life scores were all below population norm scores. Quality of life scores of the Filgrastim(r) group suggested a better quality of life than the placebo group, although none of the differences were statistically significant. There were indications that controlling for responsiveness increased the power of the design. The difference in costs between the trial groups were driven by the Filgrastim(r) costs (Euro 4899). When Filgrastim(r) costs were neglected, no difference in costs remained. Except for Filgrastim(r), total direct costs summed up to Euro 2712 and the indirect costs to Euro 582. Total direct costs of a 24-week regular treatment were three times lower than the costs of the trial treatment. While significantly increasing treatment costs, Filgrastim(r) administration does not lead to a better quality of life of chronic sinusitis patients, although there were

Some Biochemical Effects Of a Mainly Fruit Diet In Man

The effect of a nut-supplemented fruit diet on glucose tolerance, insulin secretion, plasma proteins and plasma lipids of human volunteers was investigated. The results suggest that, at least for the period covered by the experiment and under the prevailing conditions, the diet was adequate with respect to the parameters investigated, and may even have something to commend it

Some physiological effects of a mainly fruit diet in man

No Abstrac

Enzootic geophagia of calves and lambs in Northern Cape and Northwest and the possible role of chronic manganese poisoning

(South African J of Animal Science, 2000, 30, Supplement 1: 105-106

Blocking elevated p38 MAPK restores efferocytosis and inflammatory resolution in the elderly

Increasing age alters innate immune–mediated responses; however, the mechanisms underpinning these changes in humans are not fully understood. Using a human dermal model of acute inflammation, we found that, although inflammatory onset is similar between young and elderly individuals, the resolution phase was substantially impaired in elderly individuals. This arose from a reduction in T cell immunoglobulin mucin receptor-4 (TIM-4), a phosphatidylserine receptor expressed on macrophages that enables the engulfment of apoptotic bodies, so-called efferocytosis. Reduced TIM-4 in elderly individuals was caused by an elevation in macrophage p38 mitogen-activated protein kinase (MAPK) activity. Administering an orally active p38 inhibitor to elderly individuals rescued TIM-4 expression, cleared apoptotic bodies and restored a macrophage resolution phenotype. Thus, inhibiting p38 in elderly individuals rejuvenated their resolution response to be more similar to that of younger people. This is the first resolution defect identified in humans that has been successfully reversed, thereby highlighting the tractability of targeting pro-resolution biology to treat diseases driven by chronic inflammation

Genetic variations in androgen metabolism genes and associations with prostate cancer in South African men

Background. In South Africa white men have the highest incidence of prostate cancer (PCa), coloured (mixed ancestry) men have an intermediate incidence, and low incidences are reported for black and Asian men. It has been suggested that ethnic differences in incidence and mortality of PCa are related to genetic variations in genes that regulate androgen metabolism. We investigated the role of genetic variants in the androgen metabolism genes and the probability of developing PCa in South African coloured and white men. Methods. Genotype and allele counts and frequencies of single nucleotide polymorphisms (SNPs) in CYP3A5, CYP3A4 and CYP3A43 were assessed in coloured men (160 case individuals, 146 control individuals) and white men (121 case individuals, 141 control individuals). Results. A genetic association indicating an increased probability of developing PCa was observed with the G allele of the SNP rs2740574 in CYP3A4 in coloured men, the A allele of rs776746 (CYP3A5) and the G allele of rs2740574 (CYP3A4) in white men, and the G allele of rs2740574 and the C allele of rs501275 (CYP3A43) in the combined ethnic groups analysis. In addition, we identified allele combinations (termed haplotypes) with significantly higher frequencies in the PCa case individuals than in the control individuals. Conclusions. The findings support the role of variants in genes that regulate androgen metabolism and the probability of developing PCa. The study paves the way to identify other genetic associations in South African men, and to establish genetic profiles that could be used to determine disease progression and prognosis

Ecodomy - Life in its fullness

This book provides a coherent and conceptual portrayal of aspects of the theological research theme, entitled Ecodomy (literally meaning to ‘build a house’). In its figurative meaning the term Ecodomy addresses the theme, ‘life in its fullness’. This fullness of life entails a polarity which is inherently part of life, namely its brokenness and its wholeness. From various theological disciplines, namely Old Testament Studies, New Testament Studies, Systematic Theology, Church History and Practical Theology, both the brokenness and wholeness are addressed theologically. Every chapter focuses on a specific theological discipline, while the combination of theological disciplines, addresses the brokenness and wholeness of life as coherent concept. One pole does not exclude the other. Brokenness is visible in current or recent very relevant societal challenges, such as racism and xenophobia, apartheid, foreignness and exclusivism, leadership crises and violence. In contrast, wholeness is embedded in themes such as the African concept of ubuntu, a life of faith and wisdom, reconciling leadership, or transforming space and community. Ultimately, a Greek term ἀναίδεια (persistence) is connected to the meaning of Ecodomy and ‘life in its fullness’. Several methodologies have been used in the different contributions of the book. Every theological discipline applies a different methodology for the purpose of exposing a specific topic or research theme. In general, the contributions in this book follow a combination of a literature study with the further application of diachronic and synchronic exegetical methods. In addition, single contributions follow an own hermeneutical approach. Not one single contribution, but a combination of different theological disciplines, which form the concepts of brokenness and wholeness (life in its fullness), which expose the polarity of life, are included in this book. In its exposed interdisciplinary interwovenness, the book provides a tapestry of how different theological disciplines are combined into a single theme and how they contribute together by means of theological analyses and attempted building blocks to build the broken ‘houses’ of societal structures or human life. The book contributes to selected aspects of broken life in society and the healing experiences of human life. Several themes touch on recent and relevant challenges which have contributed to the brokenness of life. Not only in South Africa, but globally these are currently relevant themes. They include realities of racism and xenophobia, apartheid, foreignness and exclusivism, leadership crises and violence. With the focus on wholeness, specific attention is given to the African concept of ubuntu, a life of faith and wisdom, reconciling leadership, and transforming space and society. A Greek term ἀναίδεια (insolence as ‘in keeping on asking’ – Lk 11:8) illuminates the theme of Ecodomy from the perspective of a parable. The target audience of the book is academic scholars and theologians, who specialise in the different fields of Theology, the Humanities and other Social Sciences. Furthermore, the book is also accessible to scholars of other academic disciplines outside these disciplines. The book contains original research and contributions have not been plagiarised from publications elsewhere

Validation of a quantitative liquid chromatography tandem mass spectrometry assay for linezolid in cerebrospinal fluid and its application to patients with HIV-associated TB-meningitis.

Tuberculous meningitis treatment outcomes are poor and alternative regimens are under investigation. Reliable methods to measure drug concentrations in cerebrospinal fluid are required to evaluate distribution into the cerebrospinal fluid. A simple and quick method was developed and validated to analyse linezolid in human cerebrospinal fluid. Samples were prepared by protein precipitation followed by isocratic liquid chromatography and tandem mass spectrometry. The run time was 3.5 min. Accuracy and precision were assessed in three independent validation batches with a calibration range of 0.100-20.0 μg/mL. The method was used to analyse cerebrospinal fluid samples from patients with tuberculous meningitis enrolled in a clinical trial. Potentially infective patient samples could be decontaminated using Nanosep® nylon and Costar® nylon filter tubes under biosafety level 3 conditions before analysis. The filtration process did not significantly affect the quantification of linezolid. Linezolid concentration in cerebrospinal fluid obtained from tuberculous meningitis patients ranged from 0.197 μg/mL to 15.0 μg/mL. The ratio between average CSF and plasma linezolid concentrations varied with time, reaching a maximum of 0.9 at 6 h after dosing