86 research outputs found
Memorial Sloan-Kettering Cancer Center: Two Decades of Experience with Ductal Carcinoma In Situ of the Breast
Researchers at Memorial Sloan-Kettering Cancer Center have investigated many aspects of their experience with ductal carcinoma in situ of the breast over the past 20 years. This paper summarizes the most clinically relevant findings
Pretreatment with a 55-kDa Tumor Necrosis Factor Receptor-Immunoglobulin Fusion Protein Attenuates Activation of Coagulation, but not of Fibrinolysis, during Lethal Bacteremia in Baboons
Baboons (Papio anubis) receiving a lethal intravenous infusion with live Escherichia coli were pretreated with either a 55-kDa tumor necrosis factor (TNF) receptor-IgG fusion protein (TNFR55:IgG) (n = 4, 4.6 mg/kg) or placebo (n = 4). Neutralization of TNF activity in TNFR55:IgG-treated animals was associated with a complete prevention of mortality and a strong attenuation of coagulation activation as reflected by the plasma concentrations of thrombin-antithrombin III complexes (P < .05). Activation of fibrinolysis was not influenced by TNFR55:IgG (plasma tissue-type plasminogen activator and plasmin-a2-antiplasmin complexes), whereas TNFR55:IgG did inhibit the release of plasminogen activator inhibitor type I (P < .05). Furthermore, TNFR55:IgG inhibited neutrophil degranulation (plasma levels of elastase-α1-antitrypsin complexes, P < .05) and modestly reduced release of secretory phospholipase A2. These data suggest that endogenous TNF contributes to activation of coagulation, but not to stimulation of fibrinolysis, during severe bacteremi
Little Things
We present LITTLE THINGS (Local Irregulars That Trace Luminosity Extremes,
The HI Nearby Galaxy Survey) that is aimed at determining what drives star
formation in dwarf galaxies. This is a multi-wavelength survey of 37 Dwarf
Irregular and 4 Blue Compact Dwarf galaxies that is centered around HI-line
data obtained with the National Radio Astronomy Observatory (NRAO) Very Large
Array (VLA). The HI-line data are characterized by high sensitivity (less than
1.1 mJy/beam per channel), high spectral resolution (less than or equal to 2.6
km/s), and high angular resolution (~6 arcseconds. The LITTLE THINGS sample
contains dwarf galaxies that are relatively nearby (less than or equal to 10.3
Mpc; 6 arcseconds is less than or equal to 300 pc), that were known to contain
atomic hydrogen, the fuel for star formation, and that cover a large range in
dwarf galactic properties. We describe our VLA data acquisition, calibration,
and mapping procedures, as well as HI map characteristics, and show channel
maps, moment maps, velocity-flux profiles, and surface gas density profiles. In
addition to the HI data we have GALEX UV and ground-based UBV and Halpha images
for most of the galaxies, and JHK images for some. Spitzer mid-IR images are
available for many of the galaxies as well. These data sets are available
on-line.Comment: In press in A
Predicting Nonsentinel Node Metastases in Sentinel Node-Positive Breast Cancer: What Have We Learned, Can We Do Better, and Do We Need To?
ASO Author Reflections: Does Genomic Testing of DCIS Provide Added Value? And Is It Worth the Cost?
Long-term rates of ipsilateral breast tumor recurrence (IBTR) for women with ductal carcinoma in situ (DCIS) meeting LORIS trial eligibility criteria undergoing standard therapy.
Eighteen Sensations After Breast Cancer Surgery: A Two-Year Comparison of Sentinel Lymph Node Biopsy and Axillary Lymph Node Dissection
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