Naar een dynamische theorie van strategie, de bijdrage van Porter's diamant-model

Strategie handelt over de dynamiek van de koppeling tussen een organisatie en zijn omgeving. Op de mogelijke bijdrage van het diamant-model van Porter aan het beschrijven en verklaren van deze koppeling wordt in dit artikel ingegaan. Door middel van een longitudinale case-studie van een Nederlands bedrijf (Norit NV) wordt een en ander nader toegelicht. Daarbij wordt aandacht geschonken aan zowel het 'outside-in' als het 'inside-out' perspectief

Are individual and group treatments equally effective in the treatment of depression in adults?

0.01). At follow-up no significant differences were found. Conclusions: Although individual therapy seems to be somewhat more effective than group therapy at the short term, it is not clear whether this is relevant from a clinical point of view. Because of the small number of studies and the limited quality, more research is needed to examine whether the difference between individual and group treatment is clinically relevant

Norwegian Sea Herring Stock Discrimination phase I (NORDISI)

There is growing concern among fishermen about the migration of North Sea herring into the Norwegian Sea. The Pelagic Freezer-trawler Association therefore commissioned IMARES to develop a technique to monitor possible catches of North Sea herring in the Norwegian Sea. This technique will use morphometric (shape) differences in herring to distinguish between Norwegian Sea spawning herring and North Sea herring. The results show that the model is able to distinguish Norwegian spring spawning herring from North Sea autumn or winter spawning herring. Overall we can conclude that even though we still have to overcome some methodological problems we are confident that this research constitutes a first step towards developing a technique to monitor catches of herring from the Norwegian Sea for Norwegian Spring spawning or other herring

Anatomy of extraordinary rainfall and flash flood in a Dutch lowland catchment

On 26 August 2010 the eastern part of The Netherlands and the bordering part of Germany were struck by a series of rainfall events lasting for more than a day. Over an area of 740 km2 more than 120 mm of rainfall were observed in 24 h. This extreme event resulted in local flooding of city centres, highways and agricultural fields, and considerable financial loss. In this paper we report on the unprecedented flash flood triggered by this exceptionally heavy rainfall event in the 6.5 km2 Hupsel Brook catchment, which has been the experimental watershed employed by Wageningen University since the 1960s. This study aims to improve our understanding of the dynamics of such lowland flash floods. We present a detailed hydrometeorological analysis of this extreme event, focusing on its synoptic meteorological characteristics, its space-time rainfall dynamics as observed with rain gauges, weather radar and a microwave link, as well as the measured soil moisture, groundwater and discharge response of the catchment. At the Hupsel Brook catchment 160 mm of rainfall was observed in 24 h, corresponding to an estimated return period of well over 1000 years. As a result, discharge at the catchment outlet increased from 4.4 × 10-3 to nearly 5 m3 s-1. Within 7 h discharge rose from 5 × 10-2 to 4.5 m3 s-1. The catchment response can be divided into four phases: (1) soil moisture reservoir filling, (2) groundwater response, (3) surface depression filling and surface runoff and (4) backwater feedback. The first 35 mm of rainfall were stored in the soil without a significant increase in discharge. Relatively dry initial conditions (in comparison to those for past discharge extremes) prevented an even faster and more extreme hydrological response

New light on Chinese enterprises in Africa: Findings from a recent survey of Chinese firms in Kampala, the capital of Uganda

Abstract In this paper five issues will be analyzed. In the first place that no separation is made between providing Chinese aid, developing trade relations with China and starting investment activities in Africa. Secondly, is it true that the Chinese government helps Chinese entrepreneurs to get started in Africa. In the third place it is often suggested that Chinese entrepreneurs start after a Chinese aid project or construction job. Another issue is the presence of Chinese traders: what is the role of Chinese whole sale or retail traders in Africa and why are these entrepreneurs so successful? Finally we will look at employment and environmental issues in which Chinese entrepreneurs are said to be involved. Based on interviews of 42 Chinese enterprises in Uganda evidence is presented concerning what types of enterprises moved into Uganda and for which reason? We will analyze to what extent Chinese enterprises employ Chinese workers and Ugandan managers. What motivates these Chinese entrepreneurs to invest in Uganda and how do they deal with the challenges such as labour and environmental legislation? Which problems do they face? The relations between Uganda and China are influenced by the influx of Chinese enterprises in Uganda and the issues this raises. African countries are sensitive to the issue of Chinese companies competing with African firms. Many African countries question whether Chinese (small) traders are necessary to sell Chinese products in Africa. To what extent are 'wholesale' shops in Uganda in fact involved in retail business and how does Uganda react to this? The analysis challenges some of the generalizations concerning China's presence in Africa. We conclude that Uganda is becoming increasingly proactive in its relationship and tries to increase the contribution of Chinese enterprises to the Ugandan economy, while defining the terms on which Chinese citizens can come to work in Uganda

New Light on Chinese enterprises in Africa

In this paper five issues will be analyzed. In the first place that no separation is made between providing Chinese aid, developing trade relations with China and starting investment activities in Africa. Secondly, is it true that the Chinese government helps Chinese entrepreneurs to get started in Africa. I

Final report – Johan Cruijff ArenA Operational Pilot: Johan Cruijff ArenA Case Study

The Johan Cruijff ArenA (JC ArenA) is a big events location in Amsterdam, where national and international football matches, concerts and music festivals take place for up to 68,000 visitors. The JC ArenA is already one of the most sustainable, multi-functional stadia in the world and is realizing even more inspiring smart energy solutions for the venue, it’s visitors and neighbourhood. The JC ArenA presents a complex testbed for innovative energy services, with a consumption of electricity comparable to a district of 2700 households. Thanks to the 1 MWp solar installation on the roof of the venue, the JC ArenA already produces around 8% of the electricity it needs, the rest is by certified regional wind energy. Within the Seev4-City project the JC ArenA has invested in a 3 MW/2.8 MWh battery energy storage system, 14 EV charging stations and one V2G charging unit. The plan was to construct the 2.8 MWh battery with 148 2nd life electric car batteries, but at the moment of realisation there were not enough 2nd life EV batteries available, so 40% is 2nd life. The JC ArenA experienced compatibility issues installing a mix of new and second-life batteries. Balancing the second-life batteries with the new batteries proved far more difficult than expected because an older battery is acting different compared to new batteries. The EV-based battery energy storage system is unique in that it combines for the first time several applications and services in parallel. Main use is for grid services like Frequency Containment Reserve, along with peak shaving, back-up services, V2G support and optimization of PV integration. By integrating the solar panels, the energy storage system and the (bi-directional) EV chargers electric vehicles can power events and be charged with clean energy through the JC ArenA’s Energy Services. These and other experiences and results can serve as a development model for other stadiums worldwide and for use of 2nd life EV batteries. The results of the Seev4-City project are also given in three Key Performance Indicators (KPI): reduction of CO2-emission, increase of energy autonomy and reduction in peak demand. The results for the JC ArenA are summarised in the table below. The year 2017 is taken as reference, as most data is available for this year. The CO2 reductions are far above target thanks to the use of the battery energy storage system for FCR services, as this saves on the use of fossil energy by fossil power plants. Some smaller savings are by replacement of ICE by EV. Energy autonomy is increased by better spreading of the PV generated, over 6 instead of 4 of the 10 transformers of the JC ArenA, so less PV is going to the public grid. A peak reduction of 0.3 MW (10%) is possible by optimal use of the battery energy storage system during the main events with the highest electricity demand

Breaks in the 45S rDNA Lead to Recombination-Mediated Loss of Repeats

rDNA repeats constitute the most heavily transcribed region in the human genome. Tumors frequently display elevated levels of recombination in rDNA, indicating that the repeats are a liability to the genomic integrity of a cell. However, little is known about how cells deal with DNA double-stranded breaks in rDNA. Using selective endonucleases, we show that human cells are highly sensitive to breaks in 45S but not the 5S rDNA repeats. We find that homologous recombination inhibits repair of breaks in 45S rDNA, and this results in repeat loss. We identify the structural maintenance of chromosomes protein 5 (SMC5) as contributing to recombination-mediated repair of rDNA breaks. Together, our data demonstrate that SMC5-mediated recombination can lead to error-prone repair of 45S rDNA repeats, resulting in their loss and thereby reducing cellular viability

QRS classification and spatial combination for robust heart rate detection in low-quality fetal ECG recordings

Non-invasive fetal electrocardiography (ECG) can be used for prolonged monitoring of the fetal heart rate (FHR). However, the signal-to-noise-ratio (SNR) of non-invasive ECG recordings is often insufficient for reliable detection of the FHR. To overcome this problem, source separation techniques can be used to enhance the fetal ECG. This study uses a physiology-based source separation (PBSS) technique that has already been demonstrated to outperform widely used blind source separation techniques. Despite the relatively good performance of PBSS in enhancing the fetal ECG, PBSS is still susceptible to artifacts. In this study an augmented PBSS technique is developed to reduce the influence of artifacts. The performance of the developed method is compared to PBSS on multi-channel non-invasive fetal ECG recordings. Based on this comparison, the developed method is shown to outperform PBSS for the enhancement of the fetal ECG

Pharmacokinetics and pharmacodynamics of carboplatin administered in a high-dose combination regimen with thiotepa, cyclophosphamide and peripheral stem cell support.

The aim of this pharmacokinetic/pharmacodynamic study was to define the relationships of the carboplatin exposure with the toxicity in patients treated with high dose carboplatin (400 mg m-2 day-1), cyclophosphamide (1500 mg m-2 day-1) and thiotepa (120 mg m-2 day-1) for four consecutive days, followed by peripheral stem cell transplantation. Exposure to carboplatin was studied in 200 treatment days by measuring the area under the carboplatin plasma ultrafiltrate (pUF) concentration vs time curve (AUC). The AUC was obtained by using a previously validated limited sampling model. A total of 31 patients was studied who received one, two or three courses of this high-dose chemotherapy regimen. The unbound, plasma ultrafiltrate carboplatin was almost completely cleared from the body before each next treatment day in a course; the day-to-day AUC variation was 3.3%. The mean cumulative AUC over 4 days was 19.6 (range 14.1-27.2) mg ml-1 min-1. In 97 treatment days the carboplatin dose was calculated using the Calvert formula with the creatinine clearance as the measure for the glomerular filtration rate (GFR). For these courses, the inter-patient variability in pharmacokinetics was significantly reduced from 21% to 15% (P = 0.007) in comparison with the schemes where it was given as a fixed dose of 400 mg m-2. There were no relationships found between toxicity and the AUC of carboplatin, which may be due to the influence of overlapping toxicities of cyclophosphamide and thiotepa. However, the ototoxicity was strongly related to the cumulative carboplatin AUC. This toxicity was dose limiting for carboplatin in this schedule. It appeared that the carboplatin pharmacokinetics in these regimens were similar to those reported at conventional dosages. To reduce the inter-patient variation, the carboplatin dose can be calculated using the Calvert-formula with the creatinine clearance as the measure for the GFR