Arginine to Glutamine Substitutions in the Fourth Module of Xenopus Interphotoreceptor Retinoid-Binding Protein

Interphotoreceptor retinoid-binding protein (IRBP) is unusual for a lipid-binding protein in that its gene is expressed uniquely by cells of photoreceptor origin and consists of four homologous repeats, each coding for a module of~300 amino acid residues. All-trans retinol binding domains, which appear to be present in each module, are composed of conserved hydrophobic regions [Baer et al, Exp Eye Res 1998; 66:249-262]. Here we investigate the role of highly conserved arginines contained in these regions

The SUMup collaborative database: Surface mass balance, subsurface temperature and density measurements from the Greenland and Antarctic ice sheets (1912 - 2023)

The SUMup database is a compilation of surface mass balance (SMB), subsurface temperature and density measurements from the Greenland and Antarctic ice sheets. This 2023 release contains 4 490 442 data points: 1 778 540 SMB measurements, 2 706 413 density measurements and 5 489 subsurface temperature measurements. This is respectively 1 477 132, 420 825 and 4 715 additional observations of SMB, density and temperature compared to the 2022 release. This new release provides not only snow accumulation on ice sheets, like its predecessors, but all types of SMB measurements, including from ablation areas. On the other hand, snow depth on sea ice is discontinued, but can still be found in the previous releases. The data files are provided in both CSV and NetCDF format and contain, for each measurement, the following metadata: latitude, longitude, elevation, timestamp, method, reference of the data source and, when applicable, the name of the measurement group it belongs to (core name for SMB, profile name for density, station name for temperature). Data users are encouraged to cite all the original data sources that are being used. Issues about this release as well as suggestions of datasets to be added in next releases can be done on a dedicated user forum: https://github.com/SUMup-database/SUMup-data-suggestion/issues. Example scripts to use the SUMup 2023 files are made available on our script repository: https://github.com/SUMup-database/SUMup-example-scripts

Observation of the suppressed Λb0→DpK- decay with D→K+π- and measurement of its CP asymmetry

International audienceA study of Λb0 baryon decays to the DpK- final state is presented based on a proton-proton collision data sample corresponding to an integrated luminosity of 9  fb-1 collected with the LHCb detector. Two Λb0 decays are considered, Λb0→DpK- with D→K-π+ and D→K+π-, where D represents a superposition of D0 and D¯0 states. The latter process is expected to be suppressed relative to the former, and is observed for the first time. The ratio of branching fractions of the two decays is measured, and the CP asymmetry of the suppressed mode, which is sensitive to the Cabibbo-Kobayashi-Maskawa angle γ, is also reported