24 research outputs found
Quantitative In Vivo Magnetic Resonance Spectroscopy Using Synthetic Signal Injection
Accurate conversion of magnetic resonance spectra to quantitative units of concentration generally requires compensation for differences in coil loading conditions, the gains of the various receiver amplifiers, and rescaling that occurs during post-processing manipulations. This can be efficiently achieved by injecting a precalibrated, artificial reference signal, or pseudo-signal into the data. We have previously demonstrated, using in vitro measurements, that robust pseudo-signal injection can be accomplished using a second coil, called the injector coil, properly designed and oriented so that it couples inductively with the receive coil used to acquire the data. In this work, we acquired nonlocalized phosphorous magnetic resonance spectroscopy measurements from resting human tibialis anterior muscles and used pseudo-signal injection to calculate the Pi, PCr, and ATP concentrations. We compared these results to parallel estimates of concentrations obtained using the more established phantom replacement method. Our results demonstrate that pseudo-signal injection using inductive coupling provides a robust calibration factor that is immune to coil loading conditions and suitable for use in human measurements. Having benefits in terms of ease of use and quantitative accuracy, this method is feasible for clinical use. The protocol we describe could be readily translated for use in patients with mitochondrial disease, where sensitive assessment of metabolite content could improve diagnosis and treatment
Structure characterization of the products of the reaction between racemic 1,2,4-butane triol and di-tert-butyltin oxide
Monique Biesemans, Guy Buytaert, Luk Van Lokeren, José C. Martins, Rudolph Willem and Edward R. T. Tiekin
Sn12O8(OH)(4)(OEt)(28)(HOEt)(4): an additional member in the family of dodecameric oxo clusters
International audienc
Characterization of titanium dioxide nanoparticles dispersed in organic ligand solutions by using a diffusion-ordered spectroscopy-based strategy
International audienc
Probing the anions mediated associative behavior of tin-12 oxo-macrocations by pulsed field gradient NMR spectroscopy
International audienc