Including the most excluded? A qualitative analysis of the non-take-up of an address for people experiencing homelessness in Belgium

In many European countries, one needs a permanent address or domicile to be entitled to social rights. To address this minimum prerequisite, mechanisms for administrative inclusion are in place for people experiencing homelessness without an address, such as the reference address in Belgium. Yet, hitherto, poverty organizations raised concerns whether it succeeds in doing so. This paper disentangles the non-take-up mechanisms behind this reference address by drawing on interviews with professionals. Our evidence suggests this address is a minimum minimorum of social protection, albeit it can reflect and reinforce administrative and social exclusion of the beneficiaries through (1) the disproportionate punitive consequences when not complying to the imposed (sometimes additional) criteria, (2) their subjection to interprofessional (sometimes arbitrary) variation of the administration, and (3) their stigmatization. By focusing on this key policy targeting people experiencing homelessness, the results contribute to the debate on the entitlement to and non-take-up of rights, the barriers that homeless persons are confronted with, and the possibility of an administrative address that includes the most excluded

Researching the Non-Take up of social rights: a social work perspective

In the face of growing social, economic, political and demographic challenges, many European welfare states have been confronted with barriers in realising the social rights of certain groups of citizens. This phenomenon has often been referred to as ‘the non-take up of social rights’. Considering the core mandate and key principles of social work as a practice-based profession and academic discipline, we argue that social work should have a key role in knowledge and practice development on understanding and combating the non-take up of social rights. Our integrative contextual literature review, nonetheless, demonstrates that there is a tangible scarcity of theoretically and empirically grounded social work research that generates fruitful and indepth insights into the socially unjust situations and complex dynamics behind these processes of non-take up. This article therefore aims to identify and discuss the key knowledge gaps in the existing body of research on non-take up. As a result, we address critical foci for a future empirical social work research agenda to munition social work practice development that strongly accentuates the substantial realisation of social rights and accordingly contributes to social justice

Additional file 4: Figure S2. of KH176 under development for rare mitochondrial disease: a first in man randomized controlled clinical trial in healthy male volunteers

Posthoc ECG assessment results. A. Change in QTcF (median increase from baseline; SAD study). B. Change in TpTe (median increase from baseline; SAD study). C. Change in the T-wave symmetry index (median increase from baseline; SAD study). D. Change in QTcF (median increase from baseline; SAD study). E. Change in TpTe (median increase from baseline; MAD study). F. Change in the T-wave symmetry index (median increase from baseline; MAD study). (PDF 341 kb

Evaluation of a Cerebral-Blood-Volume (CBV) pharmaco-MRI (phMRI) assay utilizing low (0.1mg/70kg) and high (0.2mg/70kg) dose buprenorphine infusion and a novel USPIO contrast agent (Ferumoxytol) in healthy human subjects

We present results from a clinical trial of pharmaco-MRI (phMRI) employing cerebral blood volume (CBV) imaging using ferumoxytol (Rienso/Feraheme, AMAG) as a blood pool contrast agent. The study examined the pharmacodynamic effects of two single doses of buprenorphine (0.2mg/70kg and 0.1mg/70kg administered intravenously). We found that contrast-enhanced CBV phMRI signals are more sensitive reporters of pharmacodynamic effects than conventional blood oxygen level dependent (BOLD) phMRI. In particular, higher sensitivity of CBV phMRI compared to BOLD allows for elucidation of PD responses at lower doses of buprenorphine, which has practical implications for similar phMRI studies with centrally acting drugs

Supplemental Material, sj-pdf-1-rep-10.1177_25158163231191582 - Pharmacokinetic and pharmacodynamic assessments of atogepant in healthy male adults: Results from phase 1 studies

Supplemental Material, sj-pdf-1-rep-10.1177_25158163231191582 for Pharmacokinetic and pharmacodynamic assessments of atogepant in healthy male adults: Results from phase 1 studies by Ramesh Boinpally, Marleen Depré, Griet Van Lancker, Marissa F Dockendorf, Phung Bondiskey, Jean-Francois Denef, Tom Reynders, Catherine Zhou Matthews, K Chris Min, Jialin Xu, Joel M Trugman and Jan de Hoon in Cephalalgia Reports</p